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Protein Ontology Report - fam:GPCR

PR:000030035 -
Ontology Information
PRO ID PR:000030035 Show OBO stanza
PRO name G-protein coupled receptor
PRO-short-label: EXACT: fam:GPCR
Other: BROAD: 7TM receptor | seven-transmembrane receptor
Definition A protein that has G protein-coupled receptor (GPCR) activity. Each GPCR consists of a single polypeptide with an extracellular N-terminus, an intracellular C-terminus and seven hydrophobic transmembrane domains (TM1-TM7) linked by three extracellular loops (ECL1-ECL3) and three intracellular loops (ICL1-ICL3). GPCRs function as part of a heterotrimeric complex to transmit an extracellular signal across the membrane by activating an associated G-protein via the exchange of GDP for GTP on the alpha subunit. [IUPHARfam:694, PRO:DAN, Wikipedia:GPCR]
Comment Classification based on GRAFS system. [PMID:12761335]
PRO Category family
Parent PR:000000001 protein
Term Hierarchy Visualization DAG     OLS     Cytoscape