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Protein Ontology Report - free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)

PR:000035738 - http://purl.obolibrary.org/obo/PR_000035738
Ontology Information
PRO ID PR:000035738 Show OBO stanza / PAF
PRO name free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
Synonyms
Other: RELATED: activated TLR4:TRIF:TRAF:K63-pUb-TRAF6:free K63-linked pUb:activated TAK1 complex (human)
Definition A free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex whose components are encoded in the genome of human. [Reactome:R-HSA-936946]
Comment Requested by=TLR.
PRO Category organism-complex
Parent PR:000035737 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex
Taxon NCBITaxon:9606 Homo sapiens
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Specific
Category Number of Terms
organism-complex 1
Term Hierarchy Visualization DAG     OLS     Cytoscape

Complex Forms
PRO ID & Category Annotation Subunits Name Short Label Definition & Comment

Complex Subunits
Complex PRO ID Name Short Label Definition Number in Complex
PR:000035738 PR:Q8IUC6 TIR domain-containing adapter molecule 1 (human) hTICAM1 A TIR domain-containing adapter molecule 1 that is encoded in the genome of human. [PRO:CNA] 2
PR:Q15750 TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (human) hTAB1 A TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 that is encoded in the genome of human. [PRO:CNA] 2
PR:000027103 mitogen-activated protein kinase kinase kinase 7-interacting protein 2/3 (human) fam:hTAB2-hTAB3 A mitogen-activated protein kinase kinase kinase 7-interacting protein 2/3 that is encoded in the genome of human. [PMID:15327770, PRO:CNA] 2
PR:000035736 mitogen-activated protein kinase kinase kinase 7 phosphorylated 1 (human) hMAP3K7/Phos:1 A mitogen-activated protein kinase kinase kinase 7 phosphorylated 1 in human. UniProtKB:O43318, Thr-184/Thr-187, MOD:00047. [PRO:DNx, UniProtKB:O43318] 2
PR:000025786 lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 (human) hLY96/iso:1/SigPep-/NGlyco:1 A lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 in human. UniProtKB:Q9Y6Y9-1, 19-160, Asn-26/Asn-114, MOD:00160. [PMID:11593030, PMID:11706042, PMID:17569869, TLR:AMM] 2
PR:000025787 Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (human) hTLR4/iso:1/SigPep-/NGlyco:1 A Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 in human. UniProtKB:O00206-1, 24-839, Asn-35/Asn-173/Asn-205/Asn-282/Asn-309/Asn-497/Asn-526/Asn-575/Asn-624, MOD:00160. [PMID:11706042, PMID:19252480] 2
PR:000035714 TNF receptor-associated factor 6 K63-polyubiquitinated 1 (human) hTRAF6/K63polyUbiq:1 A TNF receptor-associated factor 6 K63-polyubiquitinated 1 in human. UniProtKB:Q9Y4K3, Lys-124, PR:000044772. [PRO:DAN, UniProtKB:Q9Y4K3] 2
PR:000040891 TIR domain-containing adapter molecule 2 isoform 1, initiator methionine removed myristoylated and phosphorylated 1 (human) hTICAM2/iso:1/InitMet-/MyrPhos:1 A TIR domain-containing adapter molecule 2 isoform 1, initiator methionine removed myristoylated form in human that has been myristoylated at Gly-2 and phosphorylated at Ser-16 of the amino acid sequence represented by UniProtKB:Q86XR7-1. UniProtKB:Q86XR7-1, 2-235, Gly-2, MOD:00068|Ser-16, MOD:00046. [PMID:16757566, PRO:DAN] 2
PR:000035732 K63-polyubiquitin (human) hK63polyUbiq A K63-polyubiquitin in human. [Reactome:R-HSA-450152, Reactome:R-HSA-5682839, Reactome:R-HSA-6782513] 2
CHEBI:16412 lipopolysaccharide lipopolysaccharide Natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria). [fake:1] 2


Functional Annotation
PRO Term GO Annotation Evidence
PR:000035738
free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
located_in GO:0010008 endosome membrane Reactome:REACT_26039
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0010008 endosome membrane PR:000035738 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_26039

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