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Protein Ontology Report - free K63-linked pUb:activated TAK1 complex:pUbtraf6 complex

PR:000035739 - http://purl.obolibrary.org/obo/PR_000035739
Ontology Information
PRO ID PR:000035739 Show OBO stanza / PAF
PRO name free K63-linked pUb:activated TAK1 complex:pUbtraf6 complex
Synonyms
Other: RELATED: K63-pUb-TRAF6:free K63-linked pUb:activated TAK1 complex
Definition A protein-containing complex that is composed of the ubiquitinated traf6, phosphorylated tak1, tab proteins, and free Lys-63-linked polyubiquitin. [Reactome:R-HSA-847073]
Comment Requested by=TLR.
PRO Category complex
Parent GO:0032991 protein-containing complex
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
complex 1 organism-complex 1
Term Hierarchy Visualization DAG     OLS     Cytoscape

Complex Forms
PRO ID & Category Annotation Subunits Name Short Label Definition & Comment

Complex Subunits
Complex PRO ID Name Short Label Definition Number in Complex
PR:000035740 PR:Q15750 TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (human) hTAB1 A TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 that is encoded in the genome of human. [PRO:CNA] 2
PR:000027103 mitogen-activated protein kinase kinase kinase 7-interacting protein 2/3 (human) fam:hTAB2-hTAB3 A mitogen-activated protein kinase kinase kinase 7-interacting protein 2/3 that is encoded in the genome of human. [PMID:15327770, PRO:CNA] 2
PR:000035736 mitogen-activated protein kinase kinase kinase 7 phosphorylated 1 (human) hMAP3K7/Phos:1 A mitogen-activated protein kinase kinase kinase 7 phosphorylated 1 in human. UniProtKB:O43318, Thr-184/Thr-187, MOD:00047. [PRO:DNx, UniProtKB:O43318] 2
PR:000035714 TNF receptor-associated factor 6 K63-polyubiquitinated 1 (human) hTRAF6/K63polyUbiq:1 A TNF receptor-associated factor 6 K63-polyubiquitinated 1 in human. UniProtKB:Q9Y4K3, Lys-124, PR:000044772. [PRO:DAN, UniProtKB:Q9Y4K3] 2
PR:000035732 K63-polyubiquitin (human) hK63polyUbiq A K63-polyubiquitin in human. [Reactome:R-HSA-450152, Reactome:R-HSA-5682839, Reactome:R-HSA-6782513] 2


Functional Annotation
PRO Term GO Annotation Evidence
PR:000035740
free K63-linked pUb:activated TAK1 complex:pUbtraf6 complex (human)
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_23131
acts_upstream_of_or_within GO:0002755 MyD88-dependent toll-like receptor signaling pathway Reactome:REACT_23131
located_in GO:0005829 cytosol Reactome:REACT_23131
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005829 cytosol PR:000035740 free K63-linked pUb:activated TAK1 complex:pUbtraf6 complex (human)

Reactome:REACT_23131

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