back to PRO homepage
  Home |   Linked Open Data |   Browse |   Search |   Statistics |   Download
 RACE-PRO
 PRO tracker
 Community
 PRO Consortium
 Publications
 Documentation

Protein Ontology Report - TLR4actv

PR:000036076 - http://purl.obolibrary.org/obo/PR_000036076
Ontology Information
PRO ID PR:000036076 Show OBO stanza / PAF
PRO name activated TLR4 complex
Synonyms
PRO-short-label: EXACT: TLR4actv
Other: EXACT: LY96:LPS:TLR4 complex | MD2:LPS:TLR4 complex | TLR4MD2LPS complex
Definition A protein-containing complex that contains TLR4, LPS and MD2(LY96). [PMID:19252480, PRO:DAN, Reactome:R-HSA-166041, TLR:AMM]
Comment Requested by=TLR. Based on the crystal structure, known points of disulfide bonding, and other information, it is likely that the protein components correspond to PR:000003299 and PR:000025492. [PRO:DAN]
PRO Category complex
Parent GO:0043235 receptor complex
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
complex 1 organism-complex 3
Term Hierarchy Visualization DAG     OLS     Cytoscape

Complex Forms
PRO ID & Category Annotation Subunits Name Short Label Definition & Comment

Complex Subunits
Complex PRO ID Name Short Label Definition Number in Complex
PR:000044684 PR:000025786 lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 (human) hLY96/iso:1/SigPep-/NGlyco:1 A lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 in human. UniProtKB:Q9Y6Y9-1, 19-160, Asn-26/Asn-114, MOD:00160. [PMID:11593030, PMID:11706042, PMID:17569869, TLR:AMM] 2
PR:000025787 Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (human) hTLR4/iso:1/SigPep-/NGlyco:1 A Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 in human. UniProtKB:O00206-1, 24-839, Asn-35/Asn-173/Asn-205/Asn-282/Asn-309/Asn-497/Asn-526/Asn-575/Asn-624, MOD:00160. [PMID:11706042, PMID:19252480] 2
CHEBI:16412 lipopolysaccharide lipopolysaccharide Natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria). [fake:1] 2
PR:000037474 PR:A0A1D5NZX9 lymphocyte antigen 96 (chicken) chick-LY96 A lymphocyte antigen 96 that is encoded in the genome of chicken. [OMA:A0A1D5NZX9, TLR:AMM] 2
PR:Q7ZTG5 Toll-like receptor 4 (chicken) chick-TLR4 A Toll-like receptor 4 that is encoded in the genome of chicken. [PMID:18768894, PMID:20483729, PRO:CNA] 2
CHEBI:16412 lipopolysaccharide lipopolysaccharide Natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria). [fake:1] 2
PR:000036076 PR:000003296 lymphocyte antigen 96 LY96 A protein that is a translation product of the human LY96 gene or a 1:1 ortholog thereof. [TLR:AMM] 2
PR:000001155 Toll-like receptor 4 TLR4 A Toll-like receptor that is a translation product of the human TLR4 gene or a 1:1 ortholog thereof. [PRO:CNA] 2
CHEBI:16412 lipopolysaccharide lipopolysaccharide Natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria). [fake:1] 2
PR:000036077 PR:000027171 lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 (mouse) mLY96/iso:1/SigPep-/NGlyco:1 A lymphocyte antigen 96 isoform 1, signal peptide removed glycosylated form in mouse that has been N-glycosylated on Asn residues at positions 26, 114, and 150 of the amino acid sequence represented by UniProtKB:Q9JHF9-1. UniProtKB:Q9JHF9-1, 19-160, Asn-26/Asn-114/Asn-150, MOD:00160. [PMID:17803912, PRO:CNA] 2
PR:000027172 Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (mouse) mTLR4/iso:1/SigPep-/NGlyco:1 A Toll-like receptor 4 isoform 1, signal peptide removed form in mouse that has been N-glycosylated on Asn residues at positions 34, 75, 172, 204, 237, 307, 492, 524 and 572 of the amino acid sequence represented by UniProtKB:Q9QUK6-1. UniProtKB:Q9QUK6-1, 26-835, Asn-34/Asn-75/Asn-172/Asn-204/Asn-237/Asn-307/Asn-492/Asn-524/Asn-572, MOD:00160. [PMID:17803912, PRO:CNA] 2
CHEBI:16412 lipopolysaccharide lipopolysaccharide Natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria). [fake:1] 2


Functional Annotation
PRO Term GO Annotation Evidence
PR:000037474
activated TLR4 complex (chicken)
acts_upstream_of_or_within GO:0051607 defense response to virus PMID:24034933
acts_upstream_of_or_within GO:0045429 positive regulation of nitric oxide biosynthetic process PMID:24034933
acts_upstream_of_or_within GO:0034142 toll-like receptor 4 signaling pathway PMID:18768894
located_in GO:0005886 plasma membrane Reactome:REACT_25442
PR:000036077
activated TLR4 complex (mouse)
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway PMID:23565187
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005886 plasma membrane PR:000037474 activated TLR4 complex (chicken)

Reactome:REACT_25442

top