A protein-containing complex that is composed of Ticam2 (TRAM), Ticam1 (TRIF), the death receptor RIPK1 (RIP1) cross-linked to K63-linked polyubiquitin, the IKK complex (consisting of IKKA, IKKB and NEMO), and either activated Toll-like receptor 4 (TLR4) or activated Toll-like receptor 3 (TLR3).
[PRO:DAN, Reactome:R-HSA-937030]