PRO ID |
PR:000036873
Show OBO stanza
|
PRO name |
NS2B-NS3 polyprotein precursor |
Synonyms |
PRO-short-label: |
EXACT: |
DenV-NS2B3 |
|
Definition |
A dengue virus genome polyprotein proteolytic cleavage product that is cleaved from NS12345 by the two-component protease NS2B-NS3 at the NS2A-NS2B and NS3-NS4 sites and consists of NS2B and NS3.
[PMID:10744671, PRO:ES]
|
Comment |
Requested by=IDODEN. Analysis of polyprotein processing in vivo established that the NS3 protease, as a heterodimeric complex with the viral activator protein NS2B, catalyzes the cis cleavage of NS2A-NS2B and NS2B-NS3, as well as the trans cleavage of NS3-NS4A and NS4B-NS5 sites in the polyprotein. [PMID:10744671, PRO:ES] |
PRO Category |
modification |
Parent |
PR:000036818 dengue virus genome polyprotein proteolytic cleavage product |
Term Hierarchy Visualization |
DAG
OLS
Cytoscape
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