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Protein Ontology Report - DenV-NS2B3

PR:000036873 - http://purl.obolibrary.org/obo/PR_000036873
Ontology Information
PRO ID PR:000036873 Show OBO stanza
PRO name NS2B-NS3 polyprotein precursor
Synonyms
PRO-short-label: EXACT: DenV-NS2B3
Definition A dengue virus genome polyprotein proteolytic cleavage product that is cleaved from NS12345 by the two-component protease NS2B-NS3 at the NS2A-NS2B and NS3-NS4 sites and consists of NS2B and NS3. [PMID:10744671, PRO:ES]
Comment Requested by=IDODEN. Analysis of polyprotein processing in vivo established that the NS3 protease, as a heterodimeric complex with the viral activator protein NS2B, catalyzes the cis cleavage of NS2A-NS2B and NS2B-NS3, as well as the trans cleavage of NS3-NS4A and NS4B-NS5 sites in the polyprotein. [PMID:10744671, PRO:ES]
PRO Category modification
Parent PR:000036818 dengue virus genome polyprotein proteolytic cleavage product
Term Hierarchy Visualization DAG     OLS     Cytoscape

Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

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