Protein Ontology Report - NS1 dimer PR:000037002 - http://purl.obolibrary.org/obo/PR_000037002

Ontology Information
PRO ID	PR:000037002 Show OBO stanza / PAF
PRO name	NS1 dimer
Definition	A protein-containing complex that is a dimer of NS1. [PRO:ES]
Comment	Requested by=IDODEN. Dimerization is required for NS1 transport through the Golgi system, where the glycans attached to the Asn-130 sites of the dimer and are modified to complex sugars; this is followed by transport to the plasma membrane, where a portion of NS1 is released from the cell. [PMID:15592895, PRO:ES]
PRO Category	complex
Parent	GO:0032991 protein-containing complex
Terms by PRO Category	Retrieve All terms OBO Stanza / PAF Organism-Independent Organism-Specific Category Number of Terms Category Number of Terms complex 3 organism-complex 0
Term Hierarchy Visualization	DAG     OLS     Cytoscape

Complex Forms Display Category: All All complex
PRO ID & Category Annotation Subunits Name Short Label Definition & Comment

Complex Subunits

Complex PRO ID Name Short Label Definition Number in Complex PR:000037002 PR:000036824 NS1 DenV-NS1 A dengue virus genome polyprotein proteolytic cleavage product that is the N-terminal most non-structural protein within the dengue virus genome polyprotein. Example: UniProtKB:P29990, 776-1127, Asn-905/Asn-982, MOD:00160. [PRO:ES] 2 PR:000037003 PR:000037000 NS1, with complex sugar attached DenV-NS1/sugar(+) An NS1 that has had the glycan attached to the Asn-130 site modified to a complex sugar. [PRO:ES] 2 PR:000037004 PR:000037001 NS1, without complex sugar attached DenV-NS1/sugar(-) An NS1 that has not had the glycan attached to the Asn-130 site modified to a complex sugar. [PRO:ES] 2

Functional Annotation PRO Centric View GO Centric View
PRO Term GO Annotation Evidence PR:000037002 NS1 dimer acts_upstream_of_or_within GO:0019079 viral genome replication PMID:8659120 acts_upstream_of_or_within GO:0097281 immune complex formation PMID:8659120 part_of GO:0019034 viral replication complex PMID:8659120

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