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Protein Ontology Report - pro-caspase-8:fadd:rip1:ticam1:activated TLR3 complex (human)

PR:000037368 -
Ontology Information
PRO ID PR:000037368 Show OBO stanza / PAF / GPI
PRO name pro-caspase-8:fadd:rip1:ticam1:activated TLR3 complex (human)
Other: EXACT: activated TLR3:TRIF:RIP1:FADD:pro-caspase-8 (human)
Definition A pro-caspase-8:fadd:rip1:ticam1:activated TLR3 complex whose components are encoded in the genome of human. [PMID:15814722, PMID:16115877, PMID:21737330, PMID:22421964, PRO:VS, Reactome:R-HSA-2562542]
Comment Requested by=TLR.
PRO Category organism-complex
Parent PR:000037367 pro-caspase-8:fadd:rip1:ticam1:activated TLR3 complex
Taxon NCBITaxon:9606 Homo sapiens
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Category Number of Terms
organism-complex 1
Term Hierarchy Visualization DAG     OLS     Cytoscape

Complex Forms
PRO ID & Category Annotation Subunits Name Short Label Definition & Comment

Complex Subunits
Complex PRO ID Name Short Label Definition Number in Complex
PR:000037368 PR:Q13546 receptor-interacting serine/threonine-protein kinase 1 (human) hRIPK1 A receptor-interacting serine/threonine-protein kinase 1 that is encoded in the genome of human. [PRO:DNx] 2
PR:Q14790 caspase-8 (human) hCASP8 A caspase-8 that is encoded in the genome of human. [PRO:DNx] 2
PR:Q8IUC6 TIR domain-containing adapter molecule 1 (human) hTICAM1 A TIR domain-containing adapter molecule 1 that is encoded in the genome of human. [PRO:CNA] 2
PR:Q13158 FAS-associated death domain protein (human) hFADD A FAS-associated death domain protein that is encoded in the genome of human. [PRO:DNx] 2
PR:000037305 Toll-like receptor 3, signal peptide removed form (human) hTLR3/SigPep- A Toll-like receptor 3, signal peptide removed form in human. Example: UniProtKB:O15455-1, 24-904. [PMID:15340161, PRO:CNA, Reactome:R-HSA-1678955, Reactome:R-HSA-1679057, Reactome:R-HSA-167941, Reactome:R-HSA-2000341] 2
CHEBI:67208 dsRNA dsRNA A double stranded ribonucleic acid. [None] 1

Functional Annotation
PRO Term GO Annotation Evidence
pro-caspase-8:fadd:rip1:ticam1:activated TLR3 complex (human)
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
located_in GO:0010008 endosome membrane Reactome:REACT_6783
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0010008 endosome membrane PR:000037368 pro-caspase-8:fadd:rip1:ticam1:activated TLR3 complex (human)