PRO Entry Report - PR:000037446

Protein Ontology Report - MYD88:TIRAP:PIP2:BTK:activated TLR4 complex (human)

PR:000037446 - http://purl.obolibrary.org/obo/PR_000037446

Complex Forms Complex Subunits

Ontology Information

PRO ID

PR:000037446 Show OBO stanza / GPI

PRO name

MYD88:TIRAP:PIP2:BTK:activated TLR4 complex (human)

Synonyms

Other:	EXACT:	MyD88:MAL:PI(4,5)P2:BTK:activated TLR4 (human)
	RELATED:	MyD88:Mal complexed with the activated TLR (human)

Definition

A MYD88:TIRAP:PIP2:BTK:activated TLR4 complex that is composed of MyD88, PI(4,5)P2, TIRAP/MAL, BTK, TLR4, MD2, CD14, LPS in human. [PMID:12888566, PMID:21873236, Reactome:R-HSA-166062]

PRO Category

organism-complex

Parent

PR:000037488 MYD88:TIRAP:PIP2:BTK:activated TLR4 complex

Taxon

NCBITaxon:9606 Homo sapiens

Terms by PRO Category

Retrieve All terms OBO Stanza / PAF

Organism-Specific
Category	Number of Terms
organism-complex	1

Term Hierarchy Visualization

DAG

OLS

Cytoscape

Complex Forms

PRO ID & Category Annotation Subunits	Name	Short Label	Definition & Comment

Complex Subunits

Complex	PRO ID	Name	Short Label	Definition	Number in Complex
PR:000037446	PR:Q99836	myeloid differentiation primary response protein MyD88 (human)	hMYD88	A myeloid differentiation primary response protein MyD88 that is encoded in the genome of human. [PRO:CNA]	2
	PR:000044351	tyrosine-protein kinase BTK, initiator methionine removed form (human)	hBTK/InitMet-	A tyrosine-protein kinase BTK, initiator methionine removed form in human. Example: UniProtKB:Q06187-1, 2-659. [PRO:CNA, UniProtKB:Q06187]	2
	PR:000025786	lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 (human)	hLY96/iso:1/SigPep-/NGlyco:1	A lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 in human. UniProtKB:Q9Y6Y9-1, 19-160, Asn-26/Asn-114, MOD:00160. [PMID:11593030, PMID:11706042, PMID:17569869, TLR:AMM]	2
	PR:000027214	Toll/interleukin-1 receptor domain-containing adapter protein isoform 1 phosphorylated 1 (human)	hTIRAP/iso:1/Phos:1	A Toll/interleukin-1 receptor domain-containing adapter protein isoform 1 phosphorylated 1 in human. UniProtKB:P58753-1, (Tyr-86, MOD:00048 or Tyr-106, MOD:00048 or Tyr-159, MOD:00048). [PMID:16439361, PMID:18070880, PRO:CNA]	2
	PR:000025787	Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (human)	hTLR4/iso:1/SigPep-/NGlyco:1	A Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 in human. UniProtKB:O00206-1, 24-839, Asn-35/Asn-173/Asn-205/Asn-282/Asn-309/Asn-497/Asn-526/Asn-575/Asn-624, MOD:00160. [PMID:11706042, PMID:19252480]	2
	PR:000037480	CD14 molecule isoform 1 cleaved 2 (human)	hCD14/iso:1/Clv:2	A CD14 molecule isoform 1 cleaved 2 in human. This represents both the GPI-anchored and soluble forms. [PRO:CNA, PRO:DAN]	2
	CHEBI:16412	lipopolysaccharide	lipopolysaccharide	Natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria). [fake:1]	2
	CHEBI:18348	1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate	1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate	A phosphatidylinositol bisphosphate in which the two phosphate groups are at C-4 and C-5 of the inositol moiety which has the 1D-myo configuration. [None]

top