back to PRO homepage
  Home |   Linked Open Data |   Browse |   Search |   Statistics |   Download
 RACE-PRO
 PRO tracker
 Community
 PRO Consortium
 Publications
 Documentation

Protein Ontology Report - pTIRAP:PIP2:BTK:activated TLR4 complex (mouse)

PR:000037478 - http://purl.obolibrary.org/obo/PR_000037478
Ontology Information
PRO ID PR:000037478 Show OBO stanza
PRO name pTIRAP:PIP2:BTK:activated TLR4 complex (mouse)
Synonyms
Other: EXACT: p-4Y-TIRAP:PI(4,5)P2:BTK:activated TLR4 (mouse) | p4Y-MAL:PIP2:BTK:activated TLR4 (mouse)
RELATED: p-4Y-MAL:PI(4,5)P2:BTK:activated TLR4
Definition A TIRAP:PIP2:BTK:activated TLR4 complex that is composed of PI(4,5)P2, tyrosine phosphorylated TIRAP/MAL, BTK, TLR4, MD2, and LPS in mouse. TIRAP/MAL undergoes tyrosine phosphorylation mediated by Bruton's tyrosine kinase (BTK) within the complex. [TLR:AMM]
Comment Evidence=(ECO:0000088, based on PR:000037448). Note: CD14 has not been added as part of the complex because there is not supporting evidence in mouse that CD14 is in the activated TLR4 complexes, beyond the initial transfer of LPS.
PRO Category organism-complex
Parent PR:000037472 TIRAP:PIP2:BTK:activated TLR4 complex
Taxon NCBITaxon:10090 Mus musculus
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Specific
Category Number of Terms
organism-complex 1
Term Hierarchy Visualization DAG     OLS     Cytoscape

Complex Forms
PRO ID & Category Annotation Subunits Name Short Label Definition & Comment

Complex Subunits
Complex PRO ID Name Short Label Definition Number in Complex
PR:000037478 PR:P35991 tyrosine-protein kinase BTK (mouse) mBTK A tyrosine-protein kinase BTK that is encoded in the genome of mouse. [OMA:P35991, PRO:WCB] 2
PR:000027171 lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 (mouse) mLY96/iso:1/SigPep-/NGlyco:1 A lymphocyte antigen 96 isoform 1, signal peptide removed glycosylated form in mouse that has been N-glycosylated on Asn residues at positions 26, 114, and 150 of the amino acid sequence represented by UniProtKB:Q9JHF9-1. UniProtKB:Q9JHF9-1, 19-160, Asn-26/Asn-114/Asn-150, MOD:00160. [PMID:17803912, PRO:CNA] 2
PR:000027216 Toll/interleukin-1 receptor domain-containing adapter protein phosphorylated 1 (mouse) mTIRAP/Phos:1 A Toll/interleukin-1 receptor domain-containing adapter protein (mouse) that has been phosphorylated on Tyr residues by the BTK in mouse. [PRO:CNA] 2
PR:000027172 Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (mouse) mTLR4/iso:1/SigPep-/NGlyco:1 A Toll-like receptor 4 isoform 1, signal peptide removed form in mouse that has been N-glycosylated on Asn residues at positions 34, 75, 172, 204, 237, 307, 492, 524 and 572 of the amino acid sequence represented by UniProtKB:Q9QUK6-1. UniProtKB:Q9QUK6-1, 26-835, Asn-34/Asn-75/Asn-172/Asn-204/Asn-237/Asn-307/Asn-492/Asn-524/Asn-572, MOD:00160. [PMID:17803912, PRO:CNA] 2
CHEBI:16412 lipopolysaccharide lipopolysaccharide Natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria). [fake:1] 2
CHEBI:18348 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate A phosphatidylinositol bisphosphate in which the two phosphate groups are at C-4 and C-5 of the inositol moiety which has the 1D-myo configuration. [None]


top