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Protein Ontology Report - DNMT1:PCNA:UHRF1 complex (human)

PR:000037517 -
Ontology Information
PRO ID PR:000037517 Show OBO stanza / PAF / GPI
PRO name DNMT1:PCNA:UHRF1 complex (human)
Definition A methyltransferase complex that is composed of one subunit each of DNMT1, PCNA and UHRF1 in human. [PMID:20613874, PMID:21779454, PRO:KER]
Comment Note: Promotes DNA methylation inheritance.
PRO Category organism-complex
Parent GO:0034708 methyltransferase complex
Taxon NCBITaxon:9606 Homo sapiens
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Category Number of Terms
organism-complex 1
Term Hierarchy Visualization DAG     OLS     Cytoscape

Complex Forms
PRO ID & Category Annotation Subunits Name Short Label Definition & Comment

Complex Subunits
Complex PRO ID Name Short Label Definition Number in Complex
PR:000037517 PR:P12004 proliferating cell nuclear antigen (human) hPCNA A proliferating cell nuclear antigen that is encoded in the genome of human. [PRO:DNx] 1
PR:Q96T88 E3 ubiquitin-protein ligase UHRF1 (human) hUHRF1 An E3 ubiquitin-protein ligase UHRF1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96T88] 1
PR:000037504 DNA (cytosine-5)-methyltransferase 1 unphosphorylated 1 (human) hDNMT1/UnPhos:1 A DNA (cytosine-5)-methyltransferase 1 (human) that lacks phosphorylated residues at positions equivalent to Ser-127 and Ser-143 of the amino acid sequence represented by UniProtKB:P26358-1. Example: UniProtKB:P26358-1, Ser-127/Ser-143, PR:000026291. [PMID:20613874, PRO:KER] 1

Functional Annotation
PRO Term GO Annotation Evidence
DNMT1:PCNA:UHRF1 complex (human)
associated_with_disease_suppression DOID:162 cancer PMID:20613874