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Protein Ontology Report - hPLK1/Phos:1

PR:000044818 - http://purl.obolibrary.org/obo/PR_000044818
Ontology Information
PRO ID PR:000044818 Show OBO stanza / PAF / GPI
PRO name serine/threonine-protein kinase PLK1 phosphorylated 1 (human)
Synonyms
PRO-short-label: EXACT: hPLK1/Phos:1
PRO-proteoform-std: EXACT: UniProtKB:P53350, Ser-99, MOD:00046|Thr-210, MOD:00047
Definition A serine/threonine-protein kinase PLK1 (human) that has been phosphorylated on a Ser residue that is within a 14-3-3 recognition motif, and a Thr residue that is in the activation loop and is an Aurora kinase phosphorylation site. UniProtKB:P53350, Ser-99, MOD:00046, Thr-210, MOD:00047. [PMID:23695676, PRO:CNA]
Comment Evidence=(ECO:0000006, PMID:23695676). Kinase=("AKT"; PR:000029189; Ser-99). Kinase=("AURKA"; PR:O14965; Thr-210). Note: Proteoform created based on papers selected via the eFIP text mining tool.
PRO Category organism-modification
Parent PR:P53350 serine/threonine-protein kinase PLK1 (human)
Taxon NCBITaxon:9606 Homo sapiens
Term Hierarchy Visualization DAG     OLS     Cytoscape

Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
PR:000044818
hPLK1/Phos:1
Ser-99, MOD:00046|Thr-210, MOD:00047
acts_upstream_of_or_within GO:0007091 metaphase/anaphase transition of mitotic cell cycle PMID:23695676
enables GO:0071889 14-3-3 protein binding with PR:P61981 hYWHAG PMID:23695676

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