back to PRO homepage
  Home |   Linked Open Data |   Browse |   Search |   Statistics |   Download
 PRO tracker
 PRO Consortium

Protein Ontology Report - hSMAD2/iso:Long/UnPhos:1

PR:000045371 -
Ontology Information
PRO ID PR:000045371 Show OBO stanza / PAF / GPI
PRO name smad2 isoform Long unphosphorylated 1 (human)
PRO-short-label: EXACT: hSMAD2/iso:Long/UnPhos:1
PRO-proteoform-std: EXACT: UniProtKB:Q15796-1, Ser-465/Ser-467, PR:000026291
Definition A mothers against decapentaplegic homolog 2 isoform Long (human) that lacks phosphorylation on the two last Ser of the C-terminal SSxS motif in human. UniProtKB:Q15796-1, Ser-465/Ser-467, PR:000026291. [PRO:CNA]
PRO Category organism-modification
Parent PR:Q15796-1 mothers against decapentaplegic homolog 2 isoform Long (human)
Taxon NCBITaxon:9606 Homo sapiens
Term Hierarchy Visualization DAG     OLS     Cytoscape

Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

hSMAD2/iso:Long/UnPhos:1 forms found in complexes
hSMAD2/iso:Long/UnPhos:1 Component Complexes
PR:000045371 hSMAD2/iso:Long/UnPhos:1 PR:000025965 TGF-beta 1:type II receptor:Phospho-type I receptor:SARA:SMAD2 complex (human)
PR:000045371 hSMAD2/iso:Long/UnPhos:1 PR:000025952 smad2-smad4-ski protein complex 2 (human)

Functional Annotation
PRO Term GO Annotation Evidence
Ser-465/Ser-467, PR:000026291
acts_upstream_of_or_within GO:0007179 transforming growth factor beta receptor signaling pathway PMID:8752209
enables GO:0005515 protein binding PMID:8980228
located_in GO:0005737 cytoplasm PMID:15280432, PMID:17074053
located_in GO:0005769 early endosome PMID:12356868
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005737 cytoplasm PR:000045371 hSMAD2/iso:Long/UnPhos:1
Ser-465/Ser-467, PR:000026291
PMID:15280432, PMID:17074053
GO:0005769 early endosome PR:000045371 hSMAD2/iso:Long/UnPhos:1
Ser-465/Ser-467, PR:000026291