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Protein Ontology Report - hIRF3/iso:1/Phos:2

PR:000045489 -
Ontology Information
PRO ID PR:000045489 Show OBO stanza
PRO name interferon regulatory factor 3 isoform 1 phosphorylated 2 (human)
PRO-short-label: hIRF3/iso:1/Phos:2
PRO-proteoform-std: UniProtKB:Q14653-1, Ser-339/Ser-386/Ser-398/Ser-402/Ser-405, MOD:00046|Thr-404, MOD:00047
RELATED: p-5S,T404-IRF3 (human)
Definition An interferon regulatory factor 3 isoform 1 (human) that has been phosphorylated in Ser-339 and Ser and Thr residues within the two phosphorylation cluster sites. A Ser-386 on the 2S site and multiple Ser and Thr residues in the 5ST site (Ser-396, Ser-498, Ser-402, Thr-404, and Ser-405). UniProtKB:Q14653-1, Ser-339/Ser-386/Ser-398/Ser-402/Ser-405, MOD:00046, Thr-404, MOD:00047. [PRO:CNA, Reactome:R-HSA-936418]
Comment Note: Reactome does not specify the precise isoform. However, it mentions that this proteoform is involved in dimerization. Based on the positions of the modified residues, and based on the position of the dimerization domain (203-385), only isoform 1 is eligible. [PRO:DAN, PMID:23824805]
PRO Category organism-modification
Parent PR:Q14653-1 interferon regulatory factor 3 isoform 1 (human)
Taxon NCBITaxon:9606 Homo sapiens
Term Hierarchy Visualization DAG     OLS     Cytoscape

Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

hIRF3/iso:1/Phos:2 forms found in complexes
hIRF3/iso:1/Phos:2 Component Complexes
PR:000045489 hIRF3/iso:1/Phos:2 PR:000027084 IRF3-P:IRF7-P complex (human)