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Protein Ontology Report - h(IgA1)polymeric

PR:000050165 -
Ontology Information
PRO ID PR:000050165 Show OBO stanza / GPI
PRO name polymeric IgA1 immunoglobulin complex (human)
PRO-short-label: EXACT: h(IgA1)polymeric
Other: EXACT: pIgA1 antibody (human) | polymeric IgA1 antibody (human)
BROAD: pIgA antibody (human) | polymeric IgA antibody (human)
Definition An IgA1 immunoglobulin complex, circulating (human) that is composed of two, three, or four monomeric IgA1 immunoglobulin complexes linked through both direct disulfide bonds and through disulfide binded monomers of J chain acting as a bridge. Each IgA1 monomer consists of two identical immunoglobulin heavy chains of the secretory isoform of the IgA1 isotype and two identical immunoglobulin light chains (kappa or lambda), held together by disulfide bonds. Dimeric IgA1 is sometimes complexed additionally with secretory component, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. [GOC:add, ISBN:0781765196, PMID:16362985, PRO:ADD]
Comment Requested by=HIPC. Requested by=CL. Dimeric IgA1 is by far the most common form of polymeric IgA1. In human only the IgA1 isotype is capable of a polymeric forms.
PRO Category organism-complex
Parent PR:000050159 IgA1 immunoglobulin complex, circulating (human)
Taxon NCBITaxon:9606 Homo sapiens
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Category Number of Terms
organism-complex 4
Term Hierarchy Visualization DAG     OLS     Cytoscape

Complex Forms
PRO ID & Category Annotation Subunits Name Short Label Definition & Comment

Complex Subunits
Complex PRO ID Name Short Label Definition Number in Complex