An IgG immunoglobulin complex that is composed of two immunoglobulin heavy chains of an IgG4 isotype and two immunoglobulin light chains (kappa or lambda), held together by disulfide bonds. An IgG4 immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. Note that secreted IgG4 often undergoes half-molecule exchange (exchange of one heavy chain-light chain arm for another) to form bivalent complexes (two independent binding sites) that are functionally molevalent in most biological situations.
[GOC:add, PMID:19222496, PMID:25368619, PRO:ADD]
Requested by=HIPC. Requested by=CL. Note: An IgG4 immunoglobulin complex has the function of antigen binding if a suitable antigen is available.
IgG4 heavy chain protein, secretory isoform (human)
An IgG4 heavy chain protein (human) that is a translation product of some mRNA polyadenylated at a site 5' to the membrane exons, thus preventing their incorporation the final spliced mRNA.
[GOC:add, PMID:17496345, PMID:9185563, PRO:ADD, PRO:DAN]