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Protein Ontology Report - hNRP1

PR:O14786 - http://purl.obolibrary.org/obo/PR_O14786
This page represents a class of proteins encompassing all the protein products of the NRP1 gene in human.
Ontology Information
PRO ID PR:O14786 Show OBO stanza / PAF
PRO name neuropilin-1 (human)
Synonyms
PRO-short-label: EXACT: hNRP1
Gene-based: RELATED: NRP | NRP1 | VEGF165R
Other: EXACT: CD304 (human) | vascular endothelial cell growth factor 165 receptor (human)
Definition A neuropilin-1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O14786]
PRO Category organism-gene
Parent PR:000001900 neuropilin-1
Gene Template HGNC:8004 NRP1
Taxon NCBITaxon:9606 Homo sapiens
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Specific
Category Number of Terms
organism-gene 1
organism-sequence 3
organism-modification 8
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
PR:000001900
NRP1
has_part Pfam:PF00431 CUB domain
has_part Pfam:PF00629 MAM domain, meprin/A5/mu
has_part Pfam:PF00754 F5/8 type C domain
PR:000036635
hNRP1/iso:1/SigPep-
capable_of GO:0005515 protein binding with PR:P49763-3 hPGF/iso:PlGF-2 PMID:11986311
capable_of GO:0005515 protein binding with PR:P15692-4 hVEGFA/iso:VEGF165 PMID:11986311
capable_of GO:0005515 protein binding with PR:P15692-4 hVEGFA/iso:VEGF165 PMID:16763549
capable_of GO:0008201 heparin binding PMID:11986311
capable_of GO:0043184 vascular endothelial growth factor receptor 2 binding with PR:P35968 hKDR PMID:16763549
has_part Pfam:PF00629 MAM domain, meprin/A5/mu PMID:16763549
PR:000036632
hNRP1/iso:1/ClvOGlyco:2
Ser-612, MOD:00213 		capable_of GO:0043184 vascular endothelial growth factor receptor 2 binding decreased relative to PR:000036635 hNRP1/iso:1/SigPep- with PR:P35968 hKDR PMID:16763549
capable_of GO:0005515 protein binding increased relative to PR:000036635 hNRP1/iso:1/SigPep- with PR:P15692-4 hVEGFA/iso:VEGF165 PMID:16763549
has_part Pfam:PF00629 MAM domain, meprin/A5/mu PMID:16763549
participates_in GO:0030947 regulation of vascular endothelial growth factor receptor signaling pathway PMID:16763549
PR:000036631
hNRP1/iso:1/ClvOGlyco:1
Ser-612, MOD:00215 		capable_of GO:0043184 vascular endothelial growth factor receptor 2 binding with PR:P35968 hKDR PMID:16763549
capable_of GO:0005515 protein binding increased relative to PR:000036635 hNRP1/iso:1/SigPep- with PR:P15692-4 hVEGFA/iso:VEGF165 PMID:16763549
has_part Pfam:PF00629 MAM domain, meprin/A5/mu PMID:16763549
participates_in GO:0030947 regulation of vascular endothelial growth factor receptor signaling pathway PMID:16763549
Molecular Function GO Term Protein Forms & Complexes Evidence
GO:0043184 vascular endothelial growth factor receptor 2 binding PR:000036631 hNRP1/iso:1/ClvOGlyco:1
Ser-612, MOD:00215
with PR:P35968 hKDR 		PMID:16763549
PR:000036632 hNRP1/iso:1/ClvOGlyco:2
Ser-612, MOD:00213
decreased relative to PR:000036635 hNRP1/iso:1/SigPep- with PR:P35968 hKDR 		PMID:16763549
PR:000036635 hNRP1/iso:1/SigPep-

with PR:P35968 hKDR 		PMID:16763549
GO:0008201 heparin binding PR:000036635 hNRP1/iso:1/SigPep-

PMID:11986311
GO:0005515 protein binding PR:000036631 hNRP1/iso:1/ClvOGlyco:1
Ser-612, MOD:00215
increased relative to PR:000036635 hNRP1/iso:1/SigPep- with PR:P15692-4 hVEGFA/iso:VEGF165 		PMID:16763549
PR:000036632 hNRP1/iso:1/ClvOGlyco:2
Ser-612, MOD:00213
increased relative to PR:000036635 hNRP1/iso:1/SigPep- with PR:P15692-4 hVEGFA/iso:VEGF165 		PMID:16763549
PR:000036635 hNRP1/iso:1/SigPep-

with PR:P49763-3 hPGF/iso:PlGF-2 		PMID:11986311
PR:000036635 hNRP1/iso:1/SigPep-

with PR:P15692-4 hVEGFA/iso:VEGF165 		PMID:11986311
PR:000036635 hNRP1/iso:1/SigPep-

with PR:P15692-4 hVEGFA/iso:VEGF165 		PMID:16763549
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0030947 regulation of vascular endothelial growth factor receptor signaling pathway PR:000036631 hNRP1/iso:1/ClvOGlyco:1
Ser-612, MOD:00215
PMID:16763549
PR:000036632 hNRP1/iso:1/ClvOGlyco:2
Ser-612, MOD:00213
PMID:16763549

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