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Protein Ontology Report - hIKBKB

PR:O14920 - http://purl.obolibrary.org/obo/PR_O14920
This page represents a class of proteins encompassing all the protein products of the IKBKB gene in human.
Ontology Information
PRO ID PR:O14920 Show OBO stanza / PAF
PRO name inhibitor of nuclear factor kappa-B kinase subunit beta (human)
Synonyms
PRO-short-label: EXACT: hIKBKB
Gene-based: RELATED: IKBKB | IKKB
Other: EXACT: I-kappa-B kinase 2 (human) | I-kappa-B-kinase beta (human) | IKK-B (human) | IKK-beta (human) | IKK2 (human) | IkBKB (human) | NFKBIKB (human) | nuclear factor NF-kappa-B inhibitor kinase beta (human) | serine/threonine protein kinase IKBKB (human)
Definition An inhibitor of nuclear factor kappa-B kinase subunit beta that is encoded in the genome of human. [PRO:DNx, UniProtKB:O14920]
PRO Category organism-gene
Parent PR:000001776 inhibitor of nuclear factor kappa-B kinase subunit beta
Gene Template HGNC:5960 IKBKB
Taxon NCBITaxon:9606 Homo sapiens
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Specific
Category Number of Terms
organism-gene 1
organism-sequence 4
organism-modification 1
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

hIKBKB forms found in complexes
hIKBKB Component Complexes
PR:000035831 hIKBKB/Phos:1 PR:000035833 activated IkappaB kinase complex (human)
PR:O14920 hIKBKB PR:000036053 IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:O14920 hIKBKB PR:000026457 IkappaB kinase complex (human)
PR:O14920 hIKBKB PR:000037364 IKK complex:K63-pUb-rip1:ticam1:activated TLR3 complex (human)

Functional Annotation
PRO Term GO Annotation Evidence
PR:000037364
IKK complex:K63-pUb-rip1:ticam1:activated TLR3 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_6783
participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
PR:000026457
IkappaB kinase complex (human)
participates_in GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894
PR:000036053
IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_26016
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
PR:000035833
activated IkappaB kinase complex (human)
participates_in GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0002756 MyD88-independent toll-like receptor signaling pathway PR:000036053 IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_6809
PR:000037364 IKK complex:K63-pUb-rip1:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
GO:0034142 toll-like receptor 4 signaling pathway PR:000026457 IkappaB kinase complex (human)

Reactome:REACT_6894
PR:000035833 activated IkappaB kinase complex (human)

Reactome:REACT_6894
GO:0034138 toll-like receptor 3 signaling pathway PR:000037364 IKK complex:K63-pUb-rip1:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0010008 endosome membrane PR:000036053 IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_26016
PR:000037364 IKK complex:K63-pUb-rip1:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783

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