Protein Ontology Report - hBUB1 PR:O43683 - http://purl.obolibrary.org/obo/PR_O43683

This page represents a class of proteins encompassing all the protein products of the BUB1 gene in Homo sapiens.

Ontology Information
PRO ID	PR:O43683 Show OBO stanza / PAF / GPI
PRO name	mitotic checkpoint serine/threonine-protein kinase BUB1 (human)
Synonyms	PRO-short-label: EXACT: hBUB1 Gene-based: RELATED: BUB1 | BUB1L Other: EXACT: BUB1A (human)
Definition	A mitotic checkpoint serine/threonine-protein kinase BUB1 that is encoded in the genome of human. [PMID:10749118, PMID:11030144, PMID:11792804, PMID:12719470, PMID:15190214, PMID:15525512, PMID:15592459, PMID:16760428, PMID:17671183, PMID:17785528, PMID:20016069, PMID:20624902, PMID:20703093, PRO:KER]
PRO Category	organism-gene
Parent	PR:000004854 mitotic checkpoint serine/threonine-protein kinase BUB1
Gene Template	HGNC:1148 BUB1
Taxon	NCBITaxon:9606 Homo sapiens
Terms by PRO Category	Retrieve All terms OBO Stanza / PAF Organism-Specific Category Number of Terms organism-gene 1 organism-sequence 3 organism-modification 6
Term Hierarchy Visualization	DAG     OLS     Cytoscape

Related Cross References
DB identifiers	DTO:03100052, Reactome:R-HSA-377888, UniProtKB:O43683

Interactive Sequence View Select/align proteoforms across species

Protein Forms Display Category: All All organism-gene organism-sequence organism-modification
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

hBUB1 forms found in complexes

hBUB1 Component Complexes PR:000035412 hBUB1/Phos:7 PR:000035581 phosphoBUB1:PLK1 complex (human) PR:O43683 hBUB1 PR:000035564 BUB1:BUB3 complex (human) PR:O43683 hBUB1 PR:000035576 BUB1:BUB3:APC complex (human) PR:O43683 hBUB1 PR:000035567 BUB1:BUB3:MAD1L1 complex (human) PR:O43683 hBUB1 PR:000035579 BUB1:unphosphoBUB1B complex (human) PR:O43683 hBUB1 PR:000035577 BUB1:phosphoBUB1B complex (human)

Functional Annotation PRO Centric View GO Centric View

PRO Term GO Annotation Evidence PR:O43683 hBUB1 acts_upstream_of_or_within GO:0071459 protein localization to chromosome, centromeric region PMID:16580887 acts_upstream_of_or_within GO:0071459 protein localization to chromosome, centromeric region PMID:21658950 acts_upstream_of_or_within GO:0071459 protein localization to chromosome, centromeric region PMID:21658950 acts_upstream_of_or_within GO:0071459 protein localization to chromosome, centromeric region PMID:16760428 acts_upstream_of_or_within GO:0043066 negative regulation of apoptotic process PMID:19252416 acts_upstream_of_or_within GO:0043069 negative regulation of programmed cell death PMID:20057499 acts_upstream_of_or_within GO:0031577 spindle checkpoint signaling PMID:15525512 acts_upstream_of_or_within GO:0007059 chromosome segregation PMID:16580887 acts_upstream_of_or_within GO:0007062 sister chromatid cohesion PMID:16580887 enables GO:0004672 protein kinase activity PMID:10198256 enables GO:0005515 protein binding with PR:P04637-1 hTP53/iso:1 PMID:19252416 enables GO:0005515 protein binding with PR:P25054 hAPC BioGRID:BG-302960 enables GO:0005515 protein binding with PR:O60566 hBUB1B PMID:11792804 enables GO:0005515 protein binding with PR:O43684 hBUB3 PMID:10198256, PMID:15525512 enables GO:0005515 protein binding with PR:P53350 hPLK1 BioGRID:BG-718371 enables GO:0005515 protein binding with PR:Q9Y6D9 hMAD1L1 PMID:10198256 enables GO:0005515 protein binding with PR:Q8NG31 hKNL1 BioGRID:BG-723200 located_in GO:0000940 outer kinetochore PMID:11792804, PMID:16760428 located_in GO:0000939 inner kinetochore PMID:11792804 located_in GO:0000776 kinetochore PMID:20624902 PR:000035412 hBUB1/Phos:7 Ser-593, MOD:00046|Thr-609, MOD:00047 acts_upstream_of_or_within GO:0034501 protein localization to kinetochore PMID:16760428 enables GO:0005515 protein binding increased relative to PR:000035414 Spom972h-BUB1/PhosRes- with PR:Q9NQS7 hINCENP PMID:16760428 PR:000035407 hBUB1/Phos:4 enables GO:0004672 protein kinase activity increased relative to PR:000035405 hBUB1/PhosRes- PMID:15525512 PR:000035405 hBUB1/PhosRes- enables NOT GO:0005515 protein binding with PR:P53350 hPLK1 PMID:16760428 located_in GO:0000776 kinetochore PMID:16760428 PR:000035421 hBUB1/Phos:10 Ser-314, MOD:00046 acts_upstream_of_or_within GO:0006281 DNA repair PMID:22071147 acts_upstream_of_or_within GO:0031577 spindle checkpoint signaling PMID:22099307 enables GO:0004672 protein kinase activity increased relative to PR:000035405 hBUB1/PhosRes- PMID:22071147 located_in GO:0035861 site of double-strand break PMID:22071147 Cellular Location GO Term Protein Forms & Complexes Evidence GO:0000940 outer kinetochore PR:O43683 hBUB1 PMID:11792804, PMID:16760428 GO:0035861 site of double-strand break PR:000035421 hBUB1/Phos:10 Ser-314, MOD:00046 PMID:22071147 GO:0000939 inner kinetochore PR:O43683 hBUB1 PMID:11792804 GO:0000776 kinetochore PR:000035405 hBUB1/PhosRes- PMID:16760428 PR:O43683 hBUB1 PMID:20624902

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