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Protein Ontology Report - hBUB1

PR:O43683 - http://purl.obolibrary.org/obo/PR_O43683
This page represents a class of proteins encompassing all the protein products of the BUB1 gene in human.
Ontology Information
PRO ID PR:O43683 Show OBO stanza / PAF
PRO name mitotic checkpoint serine/threonine-protein kinase BUB1 (human)
Synonyms
PRO-short-label: EXACT: hBUB1
Gene-based: RELATED: BUB1 | BUB1L
Other: EXACT: BUB1A (human)
Definition A mitotic checkpoint serine/threonine-protein kinase BUB1 that is encoded in the genome of human. [PMID:10749118, PMID:11030144, PMID:11792804, PMID:12719470, PMID:15190214, PMID:15525512, PMID:15592459, PMID:16760428, PMID:17671183, PMID:17785528, PMID:20016069, PMID:20624902, PMID:20703093, PRO:KER]
PRO Category organism-gene
Parent PR:000004854 mitotic checkpoint serine/threonine-protein kinase BUB1
Gene Template HGNC:1148 BUB1
Taxon NCBITaxon:9606 Homo sapiens
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Specific
Category Number of Terms
organism-gene 1
organism-sequence 3
organism-modification 6
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

hBUB1 forms found in complexes
hBUB1 Component Complexes
PR:000035412 hBUB1/Phos:7 PR:000035581 phosphoBUB1:PLK1 complex (human)
PR:O43683 hBUB1 PR:000035564 BUB1:BUB3 complex (human)
PR:O43683 hBUB1 PR:000035576 BUB1:BUB3:APC complex (human)
PR:O43683 hBUB1 PR:000035567 BUB1:BUB3:MAD1L1 complex (human)
PR:O43683 hBUB1 PR:000035579 BUB1:unphosphoBUB1B complex (human)
PR:O43683 hBUB1 PR:000035577 BUB1:phosphoBUB1B complex (human)

Functional Annotation
PRO Term GO Annotation Evidence
PR:O43683
hBUB1
capable_of GO:0005515 protein binding with PR:Q9Y6D9 hMAD1L1 PMID:10198256
capable_of GO:0005515 protein binding with PR:Q8NG31 hKNL1 BioGRID:BG-723200
capable_of GO:0005515 protein binding with PR:O60566 hBUB1B PMID:11792804
capable_of GO:0005515 protein binding with PR:P53350 hPLK1 BioGRID:BG-718371
capable_of GO:0005515 protein binding with PR:O43684 hBUB3 PMID:10198256, PMID:15525512
capable_of GO:0005515 protein binding with PR:P04637-1 hTP53/iso:1 PMID:19252416
capable_of GO:0005515 protein binding with PR:P25054 hAPC BioGRID:BG-302960
capable_of GO:0004672 protein kinase activity PMID:10198256
located_in GO:0000776 kinetochore PMID:20624902
located_in GO:0000939 inner kinetochore PMID:11792804
located_in GO:0000940 outer kinetochore PMID:11792804, PMID:16760428
participates_in GO:0071459 protein localization to chromosome, centromeric region PMID:16760428
participates_in GO:0007062 sister chromatid cohesion PMID:16580887
participates_in GO:0043069 negative regulation of programmed cell death PMID:20057499
participates_in GO:0007059 chromosome segregation PMID:16580887
participates_in GO:0043066 negative regulation of apoptotic process PMID:19252416
participates_in GO:0071459 protein localization to chromosome, centromeric region PMID:16580887
participates_in GO:0071459 protein localization to chromosome, centromeric region PMID:21658950
participates_in GO:0031577 spindle checkpoint signaling PMID:15525512
participates_in GO:0071459 protein localization to chromosome, centromeric region PMID:21658950
PR:000035412
hBUB1/Phos:7
Ser-593, MOD:00046|Thr-609, MOD:00047 		capable_of GO:0005515 protein binding increased relative to PR:000035414 Spom972h-BUB1/PhosRes- with PR:Q9NQS7 hINCENP PMID:16760428
participates_in GO:0034501 protein localization to kinetochore PMID:16760428
PR:000035407
hBUB1/Phos:4
capable_of GO:0004672 protein kinase activity increased relative to PR:000035405 hBUB1/PhosRes- PMID:15525512
PR:000035405
hBUB1/PhosRes-
capable_of NOT GO:0005515 protein binding with PR:P53350 hPLK1 PMID:16760428
located_in GO:0000776 kinetochore PMID:16760428
PR:000035421
hBUB1/Phos:10
Ser-314, MOD:00046 		capable_of GO:0004672 protein kinase activity increased relative to PR:000035405 hBUB1/PhosRes- PMID:22071147
located_in GO:0035861 site of double-strand break PMID:22071147
participates_in GO:0031577 spindle checkpoint signaling PMID:22099307
participates_in GO:0006281 DNA repair PMID:22071147
Molecular Function GO Term Protein Forms & Complexes Evidence
GO:0004672 protein kinase activity PR:000035407 hBUB1/Phos:4

increased relative to PR:000035405 hBUB1/PhosRes- 		PMID:15525512
PR:000035421 hBUB1/Phos:10
Ser-314, MOD:00046
increased relative to PR:000035405 hBUB1/PhosRes- 		PMID:22071147
PR:O43683 hBUB1

PMID:10198256
NOT GO:0005515 protein binding PR:000035405 hBUB1/PhosRes-

with PR:P53350 hPLK1 		PMID:16760428
GO:0005515 protein binding PR:000035412 hBUB1/Phos:7
Ser-593, MOD:00046|Thr-609, MOD:00047
increased relative to PR:000035414 Spom972h-BUB1/PhosRes- with PR:Q9NQS7 hINCENP 		PMID:16760428
PR:O43683 hBUB1

with PR:Q9Y6D9 hMAD1L1 		PMID:10198256
PR:O43683 hBUB1

with PR:Q8NG31 hKNL1 		BioGRID:BG-723200
PR:O43683 hBUB1

with PR:O60566 hBUB1B 		PMID:11792804
PR:O43683 hBUB1

with PR:P53350 hPLK1 		BioGRID:BG-718371
PR:O43683 hBUB1

with PR:O43684 hBUB3 		PMID:10198256, PMID:15525512
PR:O43683 hBUB1

with PR:P04637-1 hTP53/iso:1 		PMID:19252416
PR:O43683 hBUB1

with PR:P25054 hAPC 		BioGRID:BG-302960
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0006281 DNA repair PR:000035421 hBUB1/Phos:10
Ser-314, MOD:00046
PMID:22071147
GO:0007059 chromosome segregation PR:O43683 hBUB1

PMID:16580887
GO:0034501 protein localization to kinetochore PR:000035412 hBUB1/Phos:7
Ser-593, MOD:00046|Thr-609, MOD:00047
PMID:16760428
GO:0043069 negative regulation of programmed cell death PR:O43683 hBUB1

PMID:20057499
GO:0043066 negative regulation of apoptotic process PR:O43683 hBUB1

PMID:19252416
GO:0031577 spindle checkpoint signaling PR:000035421 hBUB1/Phos:10
Ser-314, MOD:00046
PMID:22099307
PR:O43683 hBUB1

PMID:15525512
GO:0071459 protein localization to chromosome, centromeric region PR:O43683 hBUB1

PMID:16760428
PR:O43683 hBUB1

PMID:16580887
PR:O43683 hBUB1

PMID:21658950
PR:O43683 hBUB1

PMID:21658950
GO:0007062 sister chromatid cohesion PR:O43683 hBUB1

PMID:16580887
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0000940 outer kinetochore PR:O43683 hBUB1

PMID:11792804, PMID:16760428
GO:0035861 site of double-strand break PR:000035421 hBUB1/Phos:10
Ser-314, MOD:00046
PMID:22071147
GO:0000939 inner kinetochore PR:O43683 hBUB1

PMID:11792804
GO:0000776 kinetochore PR:000035405 hBUB1/PhosRes-

PMID:16760428
PR:O43683 hBUB1

PMID:20624902

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