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Protein Ontology Report - hROCK2

PR:O75116 - http://purl.obolibrary.org/obo/PR_O75116
This page represents a class of proteins encompassing all the protein products of the ROCK2 gene in human.
Ontology Information
PRO ID PR:O75116 Show OBO stanza / PAF
PRO name Rho-associated protein kinase 2 (human)
Synonyms
PRO-short-label: EXACT: hROCK2
Gene-based: RELATED: KIAA0619 | ROCK2
Other: EXACT: ROCK-II (human) | Rho kinase 2 (human) | Rho-associated, coiled-coil-containing protein kinase 2 (human) | Rho-associated, coiled-coil-containing protein kinase II (human) | p164 ROCK-2 (human)
Definition A Rho-associated protein kinase 2 that is encoded in the genome of human. [PRO:CNA, UniProtKB:O75116]
PRO Category organism-gene
Parent PR:000000121 Rho-associated protein kinase 2
Gene Template HGNC:10252 ROCK2
Taxon NCBITaxon:9606 Homo sapiens
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Specific
Category Number of Terms
organism-gene 1
organism-sequence 1
organism-modification 3
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
PR:O75116-1
hROCK2/iso:1
capable_of GO:0031267 small GTPase binding PMID:11350930
capable_of GO:0004674 protein serine/threonine kinase activity PMID:9933571
located_in GO:0005622 intracellular anatomical structure PMID:16574662
participates_in GO:0006468 protein phosphorylation PMID:9933571
participates_in GO:0051260 protein homooligomerization PMID:15291762
PR:000036477
hROCK2/iso:1/Clv:1
capable_of GO:0004674 protein serine/threonine kinase activity increased relative to PR:000002530 ROCK2/iso:1/UnMod PMID:15699075
located_in GO:0005622 intracellular anatomical structure PMID:15699075
participates_in GO:0030036 actin cytoskeleton organization PMID:15699075
participates_in GO:0006468 protein phosphorylation PMID:15699075
PR:000036478
hROCK2/iso:1/Phos:1
Ser-1134/Ser-1137, MOD:00046
capable_of GO:0004674 protein serine/threonine kinase activity PMID:17446864
located_in GO:0005634 nucleus PMID:15302935
participates_in GO:0006468 protein phosphorylation PMID:17446864
PR:000036479
hROCK2/iso:1/Phos:2
Thr-1078, MOD:00047
participates_in GO:0006975 DNA damage induced protein phosphorylation PMID:17525332
Molecular Function GO Term Protein Forms & Complexes Evidence
GO:0004674 protein serine/threonine kinase activity PR:000036477 hROCK2/iso:1/Clv:1

increased relative to PR:000002530 ROCK2/iso:1/UnMod
PMID:15699075
PR:000036478 hROCK2/iso:1/Phos:1
Ser-1134/Ser-1137, MOD:00046
PMID:17446864
PR:O75116-1 hROCK2/iso:1

PMID:9933571
GO:0031267 small GTPase binding PR:O75116-1 hROCK2/iso:1

PMID:11350930
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0006468 protein phosphorylation PR:000036477 hROCK2/iso:1/Clv:1

PMID:15699075
PR:000036478 hROCK2/iso:1/Phos:1
Ser-1134/Ser-1137, MOD:00046
PMID:17446864
PR:O75116-1 hROCK2/iso:1

PMID:9933571
GO:0006975 DNA damage induced protein phosphorylation PR:000036479 hROCK2/iso:1/Phos:2
Thr-1078, MOD:00047
PMID:17525332
GO:0030036 actin cytoskeleton organization PR:000036477 hROCK2/iso:1/Clv:1

PMID:15699075
GO:0051260 protein homooligomerization PR:O75116-1 hROCK2/iso:1

PMID:15291762
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005634 nucleus PR:000036478 hROCK2/iso:1/Phos:1
Ser-1134/Ser-1137, MOD:00046
PMID:15302935
GO:0005622 intracellular anatomical structure PR:000036477 hROCK2/iso:1/Clv:1

PMID:15699075
PR:O75116-1 hROCK2/iso:1

PMID:16574662

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