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Protein Ontology Report - hEGFR

PR:P00533 - http://purl.obolibrary.org/obo/PR_P00533
This page represents a class of proteins encompassing all the protein products of the EGFR gene in human.
Ontology Information
PRO ID PR:P00533 Show OBO stanza / PAF
PRO name epidermal growth factor receptor (human)
Synonyms
PRO-short-label: EXACT: hEGFR
Gene-based: RELATED: EGFR | ERBB | ERBB1 | HER1
Other: EXACT: proto-oncogene c-ErbB-1 (human) | receptor tyrosine-protein kinase erbB-1 (human)
Definition An epidermal growth factor receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P00533]
PRO Category organism-gene
Parent PR:000006933 epidermal growth factor receptor
Gene Template HGNC:3236 EGFR
Taxon NCBITaxon:9606 Homo sapiens
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Specific
Category Number of Terms
organism-gene 1
organism-sequence 4
organism-modification 20
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

hEGFR forms found in complexes
hEGFR Component Complexes
PR:000028422 hEGFR/SigPep- PR:000028451 L1-EGFR trans-heterodimer (human)

Functional Annotation
PRO Term GO Annotation Evidence
PR:000049851
hEGFR/SigPep-/Phos:4
Ser-768, MOD:00046 		capable_of GO:0004713 protein tyrosine kinase activity decreased relative to PR:000049852 hEGFR/SigPep-/UnPhos:4 PMID:10347170
PR:000049849
hEGFR/SigPep-/Phos:3
Ser-1070/Ser-1071/Ser-1081/Ser-1166, MOD:00046 		capable_of GO:0004713 protein tyrosine kinase activity decreased relative to PR:000049850 hEGFR/SigPep-/UnPhos:3 PMID:10347170
capable_of GO:0005515 protein binding decreased relative to PR:000049850 hEGFR/SigPep-/UnPhos:3 with PR:P00533 hEGFR PMID:10347170
PR:000027479
hEGFR/iso:1/SigPep-/Phos:1
Tyr-869, MOD:00048 		located_in GO:0005634 nucleus PMID:18789131
participates_in GO:0034504 protein localization to nucleus PMID:18789131
Molecular Function GO Term Protein Forms & Complexes Evidence
GO:0005515 protein binding PR:000049849 hEGFR/SigPep-/Phos:3
Ser-1070/Ser-1071/Ser-1081/Ser-1166, MOD:00046
decreased relative to PR:000049850 hEGFR/SigPep-/UnPhos:3 with PR:P00533 hEGFR 		PMID:10347170
GO:0004713 protein tyrosine kinase activity PR:000049849 hEGFR/SigPep-/Phos:3
Ser-1070/Ser-1071/Ser-1081/Ser-1166, MOD:00046
decreased relative to PR:000049850 hEGFR/SigPep-/UnPhos:3 		PMID:10347170
PR:000049851 hEGFR/SigPep-/Phos:4
Ser-768, MOD:00046
decreased relative to PR:000049852 hEGFR/SigPep-/UnPhos:4 		PMID:10347170
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0034504 protein localization to nucleus PR:000027479 hEGFR/iso:1/SigPep-/Phos:1
Tyr-869, MOD:00048
PMID:18789131
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005634 nucleus PR:000027479 hEGFR/iso:1/SigPep-/Phos:1
Tyr-869, MOD:00048
PMID:18789131

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