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Protein Ontology Report - hMYC

PR:P01106 - http://purl.obolibrary.org/obo/PR_P01106
This page represents a class of proteins encompassing all the protein products of the MYC gene in human.
Ontology Information
PRO ID PR:P01106 Show OBO stanza / PAF
PRO name Myc proto-oncogene protein (human)
Synonyms
PRO-short-label: EXACT: hMYC
Gene-based: RELATED: BHLHE39 | MYC
Other: EXACT: class E basic helix-loop-helix protein 39 (human) | proto-oncogene c-Myc (human) | transcription factor p64 (human)
Definition A c-myc protein that is encoded in the genome of human. [PRO:CNA, UniProtKB:P01106]
PRO Category organism-gene
Parent PR:000000084 c-myc protein
Gene Template HGNC:7553 MYC
Taxon NCBITaxon:9606 Homo sapiens
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Specific
Category Number of Terms
organism-gene 1
organism-sequence 2
organism-modification 8
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

hMYC forms found in complexes
hMYC Component Complexes
PR:000026033 hMYC/iso:1/Ac:1 PR:000026035 Myc-max acetylated complex (human)
PR:000026038 hMYC/iso:1/UnMod PR:000026039 Myc-max complex 1 (human)
PR:P01106 hMYC PR:000025987 Myc-max complex (human)

Functional Annotation
PRO Term GO Annotation Evidence
PR:000026039
Myc-max complex 1 (human)
enables GO:0070888 E-box binding PMID:15003254
PR:P01106-1
hMYC/iso:1
acts_upstream_of_or_within GO:0051726 regulation of cell cycle PMID:10962037
acts_upstream_of_or_within GO:0006357 regulation of transcription by RNA polymerase II PMID:16908182, PMID:2006410
acts_upstream_of_or_within GO:0008283 cell population proliferation PMID:10962037
enables GO:0005515 protein binding PMID:12706874
enables GO:0003700 DNA-binding transcription factor activity PMID:16908182, PMID:2006410
part_of GO:0005667 transcription factor complex PMID:16908182, PMID:2006410
PR:P01106-2
hMYC/iso:2
enables GO:0003700 DNA-binding transcription factor activity PMID:3277717
PR:000026033
hMYC/iso:1/Ac:1
Lys-143/Lys-157/Lys-275/Lys-317/Lys-323/Lys-371, MOD:00394
enables GO:0003700 DNA-binding transcription factor activity PMID:16126174
located_in GO:0005634 nucleus PMID:16126174
part_of GO:0005667 transcription factor complex PMID:16126174
PR:000026035
Myc-max acetylated complex (human)
enables GO:0008134 transcription factor binding with PR:Q13105 hZBTB17 PMID:16126174
enables GO:0070888 E-box binding PMID:16126174
PR:000026055
hMYC/iso:1/Phos:3
Ser-62/Ser-71, MOD:00046
acts_upstream_of_or_within GO:0045766 positive regulation of angiogenesis PMID:12676581
located_in GO:0005634 nucleus PMID:12676581
PR:000026054
hMYC/iso:1/Phos:2
Thr-58, MOD:00047|Ser-62, MOD:00046
enables NOT GO:0003700 DNA-binding transcription factor activity PMID:7623799
PR:000036448
hMYC/iso:1/Phos:1
Ser-62, MOD:00046
enables GO:0005515 protein binding with PR:O15169-1 hAXIN1/iso:1 PMID:19131971
PR:000026051
hMYC/iso:1/OGlyco:1
Thr-58, MOD:00806
acts_upstream_of_or_within GO:0006357 regulation of transcription by RNA polymerase II PMID:11904304
enables GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific PMID:11904304
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005634 nucleus PR:000026033 hMYC/iso:1/Ac:1
Lys-143/Lys-157/Lys-275/Lys-317/Lys-323/Lys-371, MOD:00394
PMID:16126174
PR:000026055 hMYC/iso:1/Phos:3
Ser-62/Ser-71, MOD:00046
PMID:12676581

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