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Protein Ontology Report - hRAF1

PR:P04049 - http://purl.obolibrary.org/obo/PR_P04049
This page represents a class of proteins encompassing all the protein products of the RAF1 gene in human.
Ontology Information
PRO ID PR:P04049 Show OBO stanza / PAF
PRO name RAF proto-oncogene serine/threonine-protein kinase (human)
Synonyms
PRO-short-label: EXACT: hRAF1
Gene-based: RELATED: RAF | RAF1
Other: EXACT: Raf-1 (human) | cRaf (human) | proto-oncogene c-RAF (human)
Definition A RAF proto-oncogene serine/threonine-protein kinase that is encoded in the genome of human. [PMID:20703093, PRO:KER]
PRO Category organism-gene
Parent PR:000003244 RAF proto-oncogene serine/threonine-protein kinase
Gene Template HGNC:9829 RAF1
Taxon NCBITaxon:9606 Homo sapiens
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Specific
Category Number of Terms
organism-gene 1
organism-sequence 2
organism-modification 10
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
PR:000036643
hRAF1/iso:1/Phos:2
Ser-338/Ser-339, MOD:00046 		capable_of GO:0005515 protein binding with PR:P10415 hBCL2 PMID:15849194
capable_of GO:0004674 protein serine/threonine kinase activity PMID:15849194
located_in GO:0005741 mitochondrial outer membrane PMID:15849194
participates_in GO:0043066 negative regulation of apoptotic process PMID:15849194
PR:P04049
hRAF1
capable_of GO:0005515 protein binding with PR:O60566 hBUB1B PMID:20703093
participates_in GO:0032877 positive regulation of DNA endoreduplication PMID:20703093
Molecular Function GO Term Protein Forms & Complexes Evidence
GO:0004674 protein serine/threonine kinase activity PR:000036643 hRAF1/iso:1/Phos:2
Ser-338/Ser-339, MOD:00046
PMID:15849194
GO:0005515 protein binding PR:000036643 hRAF1/iso:1/Phos:2
Ser-338/Ser-339, MOD:00046
with PR:P10415 hBCL2 		PMID:15849194
PR:P04049 hRAF1

with PR:O60566 hBUB1B 		PMID:20703093
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0043066 negative regulation of apoptotic process PR:000036643 hRAF1/iso:1/Phos:2
Ser-338/Ser-339, MOD:00046
PMID:15849194
GO:0032877 positive regulation of DNA endoreduplication PR:P04049 hRAF1

PMID:20703093
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005741 mitochondrial outer membrane PR:000036643 hRAF1/iso:1/Phos:2
Ser-338/Ser-339, MOD:00046
PMID:15849194

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