Protein Ontology Report - hBCL2 PR:P10415 - http://purl.obolibrary.org/obo/PR_P10415

This page represents a class of proteins encompassing all the protein products of the BCL2 gene in Homo sapiens.

Ontology Information
PRO ID	PR:P10415 Show OBO stanza / PAF / GPI
PRO name	apoptosis regulator Bcl-2 (human)
Synonyms	PRO-short-label: EXACT: hBCL2 Gene-based: RELATED: BCL2
Definition	An apoptosis regulator Bcl-2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P10415]
PRO Category	organism-gene
Parent	PR:000002307 apoptosis regulator Bcl-2
Gene Template	HGNC:990 BCL2
Taxon	NCBITaxon:9606 Homo sapiens
Terms by PRO Category	Retrieve All terms OBO Stanza / PAF Organism-Specific Category Number of Terms organism-gene 1 organism-sequence 2 organism-modification 4
Term Hierarchy Visualization	DAG     OLS     Cytoscape

Related Cross References
DB identifiers	Reactome:R-HSA-50757, UniProtKB:P10415

Interactive Sequence View Select/align proteoforms across species

Protein Forms Display Category: All All organism-gene organism-sequence organism-modification
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation PRO Centric View GO Centric View

PRO Term GO Annotation Evidence PR:000027461 hBCL2/iso:1/Phos:2 Thr-74, MOD:00047 acts_upstream_of_or_within GO:0043066 negative regulation of apoptotic process PMID:12039864 PR:000027463 hBCL2/iso:1/Phos:3 Thr-69, MOD:00047|Ser-70/Ser-87, MOD:00046 acts_upstream_of_or_within GO:0016239 positive regulation of macroautophagy PMID:18570871, PMID:19029119 enables NOT GO:0005515 protein binding with PR:Q14457 hBECN1 PMID:18570871, PMID:19029119 PR:000027465 hBCL2/iso:1/Phos:4 Thr-69, MOD:00047|Ser-87, MOD:00046 acts_upstream_of_or_within GO:0043065 positive regulation of apoptotic process PMID:15703383 PR:000027467 hBCL2/iso:1/Phos:5 Thr-56, MOD:00047 acts_upstream_of_or_within GO:0045839 negative regulation of mitotic nuclear division PMID:10766756 PR:P10415-1 hBCL2/iso:Alpha acts_upstream_of_or_within GO:0070885 negative regulation of calcineurin-NFAT signaling cascade PMID:9109491 enables GO:0005515 protein binding with PR:Q07813 mBAX PMID:9109491 enables GO:0005515 protein binding with PR:P63328 mPPP3CA PMID:9109491 located_in GO:0005886 plasma membrane PMID:9109491 Cellular Location GO Term Protein Forms & Complexes Evidence GO:0005886 plasma membrane PR:P10415-1 hBCL2/iso:Alpha PMID:9109491

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