Protein Ontology Report - hAPC PR:P25054 - http://purl.obolibrary.org/obo/PR_P25054

This page represents a class of proteins encompassing all the protein products of the APC gene in Homo sapiens.

Ontology Information
PRO ID	PR:P25054 Show OBO stanza / PAF / GPI
PRO name	adenomatous polyposis coli protein (human)
Synonyms	PRO-short-label: EXACT: hAPC Gene-based: RELATED: APC | DP2.5 Other: EXACT: deleted in polyposis 2.5 (human) | protein APC (human)
Definition	An adenomatous polyposis coli protein that is encoded in the genome of human. [PMID:11283619, PMID:20823832, PRO:KER]
PRO Category	organism-gene
Parent	PR:000004122 adenomatous polyposis coli protein
Gene Template	HGNC:583 APC
Taxon	NCBITaxon:9606 Homo sapiens
Terms by PRO Category	Retrieve All terms OBO Stanza / PAF Organism-Specific Category Number of Terms organism-gene 1 organism-sequence 3 organism-modification 7
Term Hierarchy Visualization	DAG     OLS     Cytoscape

Related Cross References
DB identifiers	Reactome:R-HSA-2976015, Reactome:R-HSA-3361755, UniProtKB:P25054

Interactive Sequence View Select/align proteoforms across species

Protein Forms Display Category: All All organism-gene organism-sequence organism-modification
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

hAPC forms found in complexes
hAPC Component Complexes PR:P25054 hAPC PR:000035576 BUB1:BUB3:APC complex (human)

Functional Annotation PRO Centric View GO Centric View

PRO Term GO Annotation Evidence PR:P25054 hAPC acts_upstream_of_or_within GO:0007059 chromosome segregation PMID:11283619 acts_upstream_of_or_within NOT GO:0031577 spindle checkpoint signaling PMID:11283619 enables GO:0008017 microtubule binding PMID:11283619 enables GO:0005515 protein binding with PR:O43684 hBUB3 PMID:11283619 enables GO:0005515 protein binding with PR:O43683 hBUB1 PMID:11283619 enables GO:0005515 protein binding with PR:O14641 hDVL2 PMID:20823832 enables GO:0005515 protein binding with PR:Q13257 hMAD2L1 BioGRID:BG-302957 located_in GO:0000776 kinetochore PMID:11283619 Cellular Location GO Term Protein Forms & Complexes Evidence GO:0000776 kinetochore PR:P25054 hAPC PMID:11283619

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