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Protein Ontology Report - hAPC

PR:P25054 - http://purl.obolibrary.org/obo/PR_P25054
This page represents a class of proteins encompassing all the protein products of the APC gene in human.
Ontology Information
PRO ID PR:P25054 Show OBO stanza / PAF
PRO name adenomatous polyposis coli protein (human)
Synonyms
PRO-short-label: EXACT: hAPC
Gene-based: RELATED: APC | DP2.5
Other: EXACT: deleted in polyposis 2.5 (human) | protein APC (human)
Definition An adenomatous polyposis coli protein that is encoded in the genome of human. [PMID:11283619, PMID:20823832, PRO:KER]
PRO Category organism-gene
Parent PR:000004122 adenomatous polyposis coli protein
Gene Template HGNC:583 APC
Taxon NCBITaxon:9606 Homo sapiens
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Specific
Category Number of Terms
organism-gene 1
organism-sequence 3
organism-modification 7
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

hAPC forms found in complexes
hAPC Component Complexes
PR:P25054 hAPC PR:000035576 BUB1:BUB3:APC complex (human)

Functional Annotation
PRO Term GO Annotation Evidence
PR:P25054
hAPC
capable_of GO:0008017 microtubule binding PMID:11283619
capable_of GO:0005515 protein binding with PR:O14641 hDVL2 PMID:20823832
capable_of GO:0005515 protein binding with PR:O43684 hBUB3 PMID:11283619
capable_of GO:0005515 protein binding with PR:O43683 hBUB1 PMID:11283619
capable_of GO:0005515 protein binding with PR:Q13257 hMAD2L1 BioGRID:BG-302957
located_in GO:0000776 kinetochore PMID:11283619
participates_in GO:0007059 chromosome segregation PMID:11283619
participates_in NOT GO:0031577 spindle checkpoint signaling PMID:11283619
Molecular Function GO Term Protein Forms & Complexes Evidence
GO:0008017 microtubule binding PR:P25054 hAPC

PMID:11283619
GO:0005515 protein binding PR:P25054 hAPC

with PR:O14641 hDVL2 		PMID:20823832
PR:P25054 hAPC

with PR:O43684 hBUB3 		PMID:11283619
PR:P25054 hAPC

with PR:O43683 hBUB1 		PMID:11283619
PR:P25054 hAPC

with PR:Q13257 hMAD2L1 		BioGRID:BG-302957
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0007059 chromosome segregation PR:P25054 hAPC

PMID:11283619
NOT GO:0031577 spindle checkpoint signaling PR:P25054 hAPC

PMID:11283619
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0000776 kinetochore PR:P25054 hAPC

PMID:11283619

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