Protein Ontology Report - hDNMT1 PR:P26358 - http://purl.obolibrary.org/obo/PR_P26358

This page represents a class of proteins encompassing all the protein products of the DNMT1 gene in Homo sapiens.

Ontology Information
PRO ID	PR:P26358 Show OBO stanza / PAF / GPI
PRO name	DNA (cytosine-5)-methyltransferase 1 (human)
Synonyms	PRO-short-label: EXACT: hDNMT1 Gene-based: RELATED: AIM | CXXC9 | DNMT | DNMT1 Other: EXACT: CXXC-type zinc finger protein 9 (human) | DNA MTase HsaI (human) | DNA methyltransferase HsaI (human) | Dnmt1 (human) | M.HsaI (human) | MCMT (human)
Definition	A DNA (cytosine-5)-methyltransferase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P26358]
PRO Category	organism-gene
Parent	PR:000006606 DNA (cytosine-5)-methyltransferase 1
Gene Template	HGNC:2976 DNMT1
Taxon	NCBITaxon:9606 Homo sapiens
Terms by PRO Category	Retrieve All terms OBO Stanza / PAF Organism-Specific Category Number of Terms organism-gene 1 organism-sequence 3 organism-modification 3
Term Hierarchy Visualization	DAG     OLS     Cytoscape

Related Cross References
DB identifiers	Reactome:R-HSA-212181, UniProtKB:P26358

Interactive Sequence View Select/align proteoforms across species

Protein Forms Display Category: All All organism-gene organism-sequence organism-modification
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

hDNMT1 forms found in complexes
hDNMT1 Component Complexes PR:000037504 hDNMT1/UnPhos:1 PR:000037517 DNMT1:PCNA:UHRF1 complex (human)

Functional Annotation PRO Centric View GO Centric View

PRO Term GO Annotation Evidence PR:000037506 hDNMT1/Phos:2 Ser-127/Ser-143, MOD:00046 enables GO:0005515 protein binding decreased relative to PR:000037504 hDNMT1/UnPhos:1 with PR:Q96T88 hUHRF1 PMID:20613874 enables GO:0005515 protein binding decreased relative to PR:000037504 hDNMT1/UnPhos:1 with PR:P12004 hPCNA PMID:20613874 PR:000037505 hDNMT1/Phos:1 Ser-127, MOD:00046 enables GO:0005515 protein binding decreased relative to PR:000037504 hDNMT1/UnPhos:1 with PR:Q96T88 hUHRF1 PMID:20613874 enables GO:0005515 protein binding decreased relative to PR:000037504 hDNMT1/UnPhos:1 with PR:P12004 hPCNA PMID:20613874 PR:000037504 hDNMT1/UnPhos:1 Ser-127/Ser-143, PR:000026291 enables GO:0005515 protein binding with PR:Q96T88 hUHRF1 PMID:20613874 enables GO:0005515 protein binding with PR:P12004 hPCNA PMID:20613874 PR:000037517 DNMT1:PCNA:UHRF1 complex (human) associated_with_disease_suppression DOID:162 cancer PMID:20613874

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