Protein Ontology Report - hAKT1 PR:P31749 - http://purl.obolibrary.org/obo/PR_P31749

This page represents a class of proteins encompassing all the protein products of the AKT1 gene in Homo sapiens.

Ontology Information
PRO ID	PR:P31749 Show OBO stanza / PAF / GPI
PRO name	RAC-alpha serine/threonine-protein kinase (human)
Synonyms	PRO-short-label: EXACT: hAKT1 Gene-based: RELATED: AKT1 | PKB | RAC Other: EXACT: PKB alpha (human) | RAC-PK-alpha (human) | protein kinase B (human) | protein kinase B alpha (human) | proto-oncogene c-Akt (human)
Definition	A RAC-alpha serine/threonine-protein kinase that is encoded in the genome of human. [PRO:WCB, UniProtKB:P31749]
PRO Category	organism-gene
Parent	PR:000002190 RAC-alpha serine/threonine-protein kinase
Gene Template	HGNC:391 AKT1
Taxon	NCBITaxon:9606 Homo sapiens
Terms by PRO Category	Retrieve All terms OBO Stanza / PAF Organism-Specific Category Number of Terms organism-gene 1 organism-sequence 2 organism-modification 6
Term Hierarchy Visualization	DAG     OLS     Cytoscape

Related Cross References
DB identifiers	DTO:03100019, Reactome:R-HSA-199416, Reactome:R-HSA-58252, UniProtKB:P31749

Interactive Sequence View Select/align proteoforms across species

Protein Forms Display Category: All All organism-gene organism-sequence organism-modification
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation PRO Centric View GO Centric View

PRO Term GO Annotation Evidence PR:000028994 hAKT1/iso:1/Phos:1 Thr-308, MOD:00047|Ser-473, MOD:00046 acts_upstream_of_or_within GO:0051092 positive regulation of NF-kappaB transcription factor activity PMID:12138205 acts_upstream_of_or_within GO:0032869 cellular response to insulin stimulus PMID:8978681 enables GO:0004672 protein kinase activity PMID:8978681 enables GO:0005515 protein binding with PR:P41279-1 hMAP3K8/iso:1 PMID:12138205 enables GO:0005515 protein binding with PR:O14746-1 hTERT/iso:1 PMID:12586360 enables GO:0004674 protein serine/threonine kinase activity PMID:12138205 PR:000027473 hAKT1/iso:1/Phos:2 Thr-72/Thr-308, MOD:00047|Ser-246/Ser-473, MOD:00046 acts_upstream_of_or_within GO:0043066 negative regulation of apoptotic process PMID:16549426

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