Protein Ontology Report - hGDF5 PR:P43026 - http://purl.obolibrary.org/obo/PR_P43026

This page represents a class of proteins encompassing all the protein products of the GDF5 gene in Homo sapiens.

Ontology Information
PRO ID	PR:P43026 Show OBO stanza / PAF / GPI
PRO name	growth/differentiation factor 5 (human)
Synonyms	PRO-short-label: EXACT: hGDF5 Gene-based: RELATED: BMP14 | CDMP1 | GDF5 Other: EXACT: BMP-14 (human) | CDMP-1 (human) | GDF-5 (human) | LAP-4 (human) | LPS-associated protein 4 (human) | bone morphogenetic protein 14 (human) | cartilage-derived morphogenetic protein 1 (human) | lipopolysaccharide-associated protein 4 (human) | radotermin (human)
Definition	A growth/differentiation factor 5 that is encoded in the genome of human. [PRO:CNA, UniProtKB:P43026]
PRO Category	organism-gene
Parent	PR:000000281 growth/differentiation factor 5
Gene Template	HGNC:4220 GDF5
Taxon	NCBITaxon:9606 Homo sapiens
Terms by PRO Category	Retrieve All terms OBO Stanza / PAF Organism-Specific Category Number of Terms organism-gene 1 organism-sequence 4 organism-modification 2
Term Hierarchy Visualization	DAG     OLS     Cytoscape

Related Cross References
DB identifiers	UniProtKB:P43026

Interactive Sequence View Select/align proteoforms across species

Protein Forms Display Category: All All organism-gene organism-sequence organism-modification
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation PRO Centric View GO Centric View

PRO Term GO Annotation Evidence PR:000000437 hGDF5/var:C400Y Cys-400, CHEBI:46858 associated_with_disease_progression DOID:0080052 acromesomelic dysplasia, Grebe type UniProtKB_VAR:VAR_017407 enables NOT GO:0008083 growth factor activity PMID:9288098 enables GO:0005515 protein binding with PR:000000164 BMP2 PMID:9288098 located_in GO:0005622 intracellular anatomical structure PMID:9288098 PR:000000281 GDF5 acts_upstream_of_or_within GO:0030326 embryonic limb morphogenesis PANTHER:PTHR11848:SF44 PR:P43026-1 hGDF5/iso:1 acts_upstream_of_or_within GO:0007267 cell-cell signaling PMID:8589725 acts_upstream_of_or_within GO:0007179 transforming growth factor beta receptor signaling pathway PMID:7961761 PR:000000439 hGDF5/var:L441P Leu-441, CHEBI:50342 associated_with_disease_progression DOID:0050790 fibular hypoplasia and complex brachydactyly UniProtKB_VAR:VAR_017408 PR:000000438 hGDF5/var:R438L Arg-438, CHEBI:30006 associated_with_disease_progression DOID:0050794 multiple synostoses syndrome PMID:16532400 located_in GO:0005615 extracellular space PMID:16532400 PR:000036543 hGDF5/iso:1/Clv:1 enables GO:0005102 signaling receptor binding PMID:15752764, PMID:15890363 enables GO:0008083 growth factor activity PMID:8589725 enables GO:0042803 protein homodimerization activity PMID:15752764, PMID:8962721 enables GO:0005515 protein binding with PR:P12643 hBMP2 PMID:9288098 located_in GO:0005615 extracellular space PMID:16532400 Cellular Location GO Term Protein Forms & Complexes Evidence GO:0005622 intracellular anatomical structure PR:000000437 hGDF5/var:C400Y Cys-400, CHEBI:46858 PMID:9288098 GO:0005615 extracellular space PR:000000438 hGDF5/var:R438L Arg-438, CHEBI:30006 PMID:16532400 PR:000036543 hGDF5/iso:1/Clv:1 PMID:16532400

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