Protein Ontology Report - hCDKN1B PR:P46527 - http://purl.obolibrary.org/obo/PR_P46527

This page represents a class of proteins encompassing all the protein products of the CDKN1B gene in human.

Ontology Information
PRO ID	PR:P46527 Show OBO stanza / PAF
PRO name	cyclin-dependent kinase inhibitor 1B (human)
Synonyms	PRO-short-label: hCDKN1B EXACT: cyclin-dependent kinase inhibitor p27 (human); p27Kip1 (human) Gene-based: CDKN1B; KIP1
Definition	A cyclin-dependent kinase inhibitor 1B that is encoded in the genome of human. [PRO:CNA, UniProtKB:P46527]
Comment	Requested by=PubChem.
PRO Category	organism-gene
Parent	PR:000003090 cyclin-dependent kinase inhibitor 1B
Gene Template	HGNC:1785 CDKN1B
Taxon	NCBITaxon:9606 Homo sapiens
Terms by PRO Category	Retrieve All terms OBO Stanza / PAF Organism-Specific Category Number of Terms organism-gene 1 organism-sequence 1 organism-modification 7
Term Hierarchy Visualization	DAG     OLS     Cytoscape

Related Cross References
DB identifiers	Reactome:R-HSA-182563, Reactome:R-HSA-198622, UniProtKB:P46527

Interactive Sequence View Select/align proteoforms across species

Protein Forms Display Category: All All organism-gene organism-sequence organism-modification
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation PRO Centric View GO Centric View

PRO Term GO Annotation Evidence PR:000036634 hCDKN1B/iso:1/Phos:1 Thr-157, MOD:00047 capable_of GO:0005515 protein binding with PR:P31946 hYWHAB PMID:15057270 capable_of GO:0005515 protein binding with PR:P62258 hYWHAE PMID:15057270 capable_of GO:0005515 protein binding decreased relative to PR:000003092 CDKN1B/iso:1/UnMod with PR:P52294 hKPNA1 PMID:15057270 capable_of GO:0005515 protein binding with PR:P61981 hYWHAG PMID:15057270 located_in GO:0005737 cytoplasm PMID:15057270 located_in GO:0005829 cytosol PMID:12244301 participates_in GO:0008284 positive regulation of cell population proliferation PMID:12244301 PR:000025750 hCDKN1B/iso:1/Phos:2 Tyr-88, MOD:00048 capable_of GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity decreased relative to PR:000045370 hCDKN1B/iso:1/UnPhos:2 PMID:17254966 capable_of GO:0005515 protein binding with PR:P20248 hCCNA2 PMID:17254966 capable_of GO:0044877 protein-containing complex binding with PR:000026741 cyclin D1:Cdk4 (human) PMID:17254966 capable_of GO:0005515 protein binding with PR:P24385 hCCND1 PMID:17254966 capable_of GO:0005515 protein binding with PR:P24864 hCCNE1 PMID:17254966 participates_in GO:0051318 G1 phase PMID:17254966 PR:000045370 hCDKN1B/iso:1/UnPhos:2 Tyr-88, PR:000026291 capable_of GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity PMID:17254966 capable_of GO:0044877 protein-containing complex binding with PR:000026741 cyclin D1:Cdk4 (human) PMID:17254966 capable_of GO:0005515 protein binding with PR:P31749 hAKT1 PMID:12244301 located_in GO:0005634 nucleus PMID:12244301 participates_in GO:0051318 G1 phase PMID:17254966 participates_in GO:0008285 negative regulation of cell population proliferation PMID:12244301 Biological Process GO Term Protein Forms & Complexes Evidence GO:0008285 negative regulation of cell population proliferation PR:000045370 hCDKN1B/iso:1/UnPhos:2 Tyr-88, PR:000026291 PMID:12244301 GO:0008284 positive regulation of cell population proliferation PR:000036634 hCDKN1B/iso:1/Phos:1 Thr-157, MOD:00047 PMID:12244301 GO:0051318 G1 phase PR:000025750 hCDKN1B/iso:1/Phos:2 Tyr-88, MOD:00048 PMID:17254966 PR:000045370 hCDKN1B/iso:1/UnPhos:2 Tyr-88, PR:000026291 PMID:17254966 Cellular Location GO Term Protein Forms & Complexes Evidence GO:0005829 cytosol PR:000036634 hCDKN1B/iso:1/Phos:1 Thr-157, MOD:00047 PMID:12244301 GO:0005737 cytoplasm PR:000036634 hCDKN1B/iso:1/Phos:1 Thr-157, MOD:00047 PMID:15057270 GO:0005634 nucleus PR:000045370 hCDKN1B/iso:1/UnPhos:2 Tyr-88, PR:000026291 PMID:12244301

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