PRO Entry Report - PR:P46527

Protein Ontology Report - hCDKN1B

PR:P46527 - http://purl.obolibrary.org/obo/PR_P46527

This page represents a class of proteins encompassing all the protein products of the CDKN1B gene in human.

Protein Forms Annotations

Ontology Information

PRO ID

PR:P46527 Show OBO stanza / PAF

PRO name

cyclin-dependent kinase inhibitor 1B (human)

Synonyms

PRO-short-label:	EXACT:	hCDKN1B
Gene-based:	RELATED:	CDKN1B \| KIP1
Other:	EXACT:	cyclin-dependent kinase inhibitor p27 (human) \| p27Kip1 (human)

Definition

A cyclin-dependent kinase inhibitor 1B that is encoded in the genome of human. [PRO:CNA, UniProtKB:P46527]

Comment

Requested by=PubChem.

PRO Category

organism-gene

Parent

PR:000003090 cyclin-dependent kinase inhibitor 1B

Gene Template

HGNC:1785 CDKN1B

Taxon

NCBITaxon:9606 Homo sapiens

Terms by PRO Category

Retrieve All terms OBO Stanza / PAF

Organism-Specific
Category	Number of Terms
organism-gene	1
organism-sequence	1
organism-modification	7

Term Hierarchy Visualization

DAG

OLS

Cytoscape

Related Cross References
DB identifiers	Reactome:R-HSA-182563, Reactome:R-HSA-198622, UniProtKB:P46527

Interactive Sequence View Select/align proteoforms across species

Protein Forms

PRO ID & Category Annotation Complex	Name	Short Label	Definition & Comment

Functional Annotation

PRO Centric View
GO Centric View

PRO Term	GO Annotation		Evidence
PR:000036634 hCDKN1B/iso:1/Phos:1 Thr-157, MOD:00047	capable_of	GO:0005515 protein binding with PR:P62258 hYWHAE	PMID:15057270
	capable_of	GO:0005515 protein binding with PR:P31946 hYWHAB	PMID:15057270
	capable_of	GO:0005515 protein binding with PR:P61981 hYWHAG	PMID:15057270
	capable_of	GO:0005515 protein binding decreased relative to PR:000003092 CDKN1B/iso:1/UnMod with PR:P52294 hKPNA1	PMID:15057270
	located_in	GO:0005829 cytosol	PMID:12244301
	located_in	GO:0005737 cytoplasm	PMID:15057270
	participates_in	GO:0008284 positive regulation of cell population proliferation	PMID:12244301
PR:000025750 hCDKN1B/iso:1/Phos:2 Tyr-88, MOD:00048	capable_of	GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity decreased relative to PR:000045370 hCDKN1B/iso:1/UnPhos:2	PMID:17254966
	capable_of	GO:0005515 protein binding with PR:P24864 hCCNE1	PMID:17254966
	capable_of	GO:0005515 protein binding with PR:P24385 hCCND1	PMID:17254966
	capable_of	GO:0005515 protein binding with PR:P20248 hCCNA2	PMID:17254966
	capable_of	GO:0044877 protein-containing complex binding with PR:000026741 cyclin D1:Cdk4 (human)	PMID:17254966
	participates_in	GO:0051318 G1 phase	PMID:17254966
PR:000045370 hCDKN1B/iso:1/UnPhos:2 Tyr-88, PR:000026291	capable_of	GO:0005515 protein binding with PR:P31749 hAKT1	PMID:12244301
	capable_of	GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity	PMID:17254966
	capable_of	GO:0044877 protein-containing complex binding with PR:000026741 cyclin D1:Cdk4 (human)	PMID:17254966
	located_in	GO:0005634 nucleus	PMID:12244301
	participates_in	GO:0051318 G1 phase	PMID:17254966
	participates_in	GO:0008285 negative regulation of cell population proliferation	PMID:12244301

Molecular Function GO Term	Protein Forms & Complexes	Evidence
GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity	PR:000025750 hCDKN1B/iso:1/Phos:2 Tyr-88, MOD:00048 decreased relative to PR:000045370 hCDKN1B/iso:1/UnPhos:2	PMID:17254966
	PR:000045370 hCDKN1B/iso:1/UnPhos:2 Tyr-88, PR:000026291	PMID:17254966
GO:0005515 protein binding	PR:000025750 hCDKN1B/iso:1/Phos:2 Tyr-88, MOD:00048 with PR:P24864 hCCNE1	PMID:17254966
	PR:000025750 hCDKN1B/iso:1/Phos:2 Tyr-88, MOD:00048 with PR:P24385 hCCND1	PMID:17254966
	PR:000025750 hCDKN1B/iso:1/Phos:2 Tyr-88, MOD:00048 with PR:P20248 hCCNA2	PMID:17254966
	PR:000036634 hCDKN1B/iso:1/Phos:1 Thr-157, MOD:00047 with PR:P62258 hYWHAE	PMID:15057270
	PR:000036634 hCDKN1B/iso:1/Phos:1 Thr-157, MOD:00047 with PR:P31946 hYWHAB	PMID:15057270
	PR:000036634 hCDKN1B/iso:1/Phos:1 Thr-157, MOD:00047 with PR:P61981 hYWHAG	PMID:15057270
	PR:000036634 hCDKN1B/iso:1/Phos:1 Thr-157, MOD:00047 decreased relative to PR:000003092 CDKN1B/iso:1/UnMod with PR:P52294 hKPNA1	PMID:15057270
	PR:000045370 hCDKN1B/iso:1/UnPhos:2 Tyr-88, PR:000026291 with PR:P31749 hAKT1	PMID:12244301
GO:0044877 protein-containing complex binding	PR:000025750 hCDKN1B/iso:1/Phos:2 Tyr-88, MOD:00048 with PR:000026741 cyclin D1:Cdk4 (human)	PMID:17254966
GO:0044877 protein-containing complex binding	PR:000045370 hCDKN1B/iso:1/UnPhos:2 Tyr-88, PR:000026291 with PR:000026741 cyclin D1:Cdk4 (human)	PMID:17254966

Biological Process GO Term	Protein Forms & Complexes	Evidence
GO:0008285 negative regulation of cell population proliferation	PR:000045370 hCDKN1B/iso:1/UnPhos:2 Tyr-88, PR:000026291	PMID:12244301
GO:0008284 positive regulation of cell population proliferation	PR:000036634 hCDKN1B/iso:1/Phos:1 Thr-157, MOD:00047	PMID:12244301
GO:0051318 G1 phase	PR:000025750 hCDKN1B/iso:1/Phos:2 Tyr-88, MOD:00048	PMID:17254966
GO:0051318 G1 phase	PR:000045370 hCDKN1B/iso:1/UnPhos:2 Tyr-88, PR:000026291	PMID:17254966

Cellular Location GO Term	Protein Forms & Complexes	Evidence
GO:0005829 cytosol	PR:000036634 hCDKN1B/iso:1/Phos:1 Thr-157, MOD:00047	PMID:12244301
GO:0005737 cytoplasm	PR:000036634 hCDKN1B/iso:1/Phos:1 Thr-157, MOD:00047	PMID:15057270
GO:0005634 nucleus	PR:000045370 hCDKN1B/iso:1/UnPhos:2 Tyr-88, PR:000026291	PMID:12244301

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