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Protein Ontology Report - hCDKN1B

PR:P46527 - http://purl.obolibrary.org/obo/PR_P46527
This page represents a class of proteins encompassing all the protein products of the CDKN1B gene in human.
Ontology Information
PRO ID PR:P46527 Show OBO stanza / PAF
PRO name cyclin-dependent kinase inhibitor 1B (human)
Synonyms
PRO-short-label: hCDKN1B
EXACT: cyclin-dependent kinase inhibitor p27 (human); p27Kip1 (human)
Gene-based: CDKN1B; KIP1
Definition A cyclin-dependent kinase inhibitor 1B that is encoded in the genome of human. [PRO:CNA, UniProtKB:P46527]
Comment Requested by=PubChem.
PRO Category organism-gene
Parent PR:000003090 cyclin-dependent kinase inhibitor 1B
Gene Template HGNC:1785 CDKN1B
Taxon NCBITaxon:9606 Homo sapiens
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Specific
Category Number of Terms
organism-gene 1
organism-sequence 1
organism-modification 7
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
PR:000036634
hCDKN1B/iso:1/Phos:1
Thr-157, MOD:00047
capable_of GO:0005515 protein binding with PR:P31946 hYWHAB PMID:15057270
capable_of GO:0005515 protein binding with PR:P62258 hYWHAE PMID:15057270
capable_of GO:0005515 protein binding decreased relative to PR:000003092 CDKN1B/iso:1/UnMod with PR:P52294 hKPNA1 PMID:15057270
capable_of GO:0005515 protein binding with PR:P61981 hYWHAG PMID:15057270
located_in GO:0005737 cytoplasm PMID:15057270
located_in GO:0005829 cytosol PMID:12244301
participates_in GO:0008284 positive regulation of cell population proliferation PMID:12244301
PR:000025750
hCDKN1B/iso:1/Phos:2
Tyr-88, MOD:00048
capable_of GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity decreased relative to PR:000045370 hCDKN1B/iso:1/UnPhos:2 PMID:17254966
capable_of GO:0005515 protein binding with PR:P20248 hCCNA2 PMID:17254966
capable_of GO:0044877 protein-containing complex binding with PR:000026741 cyclin D1:Cdk4 (human) PMID:17254966
capable_of GO:0005515 protein binding with PR:P24385 hCCND1 PMID:17254966
capable_of GO:0005515 protein binding with PR:P24864 hCCNE1 PMID:17254966
participates_in GO:0051318 G1 phase PMID:17254966
PR:000045370
hCDKN1B/iso:1/UnPhos:2
Tyr-88, PR:000026291
capable_of GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity PMID:17254966
capable_of GO:0044877 protein-containing complex binding with PR:000026741 cyclin D1:Cdk4 (human) PMID:17254966
capable_of GO:0005515 protein binding with PR:P31749 hAKT1 PMID:12244301
located_in GO:0005634 nucleus PMID:12244301
participates_in GO:0051318 G1 phase PMID:17254966
participates_in GO:0008285 negative regulation of cell population proliferation PMID:12244301
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0008285 negative regulation of cell population proliferation PR:000045370 hCDKN1B/iso:1/UnPhos:2
Tyr-88, PR:000026291
PMID:12244301
GO:0008284 positive regulation of cell population proliferation PR:000036634 hCDKN1B/iso:1/Phos:1
Thr-157, MOD:00047
PMID:12244301
GO:0051318 G1 phase PR:000025750 hCDKN1B/iso:1/Phos:2
Tyr-88, MOD:00048
PMID:17254966
PR:000045370 hCDKN1B/iso:1/UnPhos:2
Tyr-88, PR:000026291
PMID:17254966
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005829 cytosol PR:000036634 hCDKN1B/iso:1/Phos:1
Thr-157, MOD:00047
PMID:12244301
GO:0005737 cytoplasm PR:000036634 hCDKN1B/iso:1/Phos:1
Thr-157, MOD:00047
PMID:15057270
GO:0005634 nucleus PR:000045370 hCDKN1B/iso:1/UnPhos:2
Tyr-88, PR:000026291
PMID:12244301

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