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Protein Ontology Report - hFASLG

PR:P48023 - http://purl.obolibrary.org/obo/PR_P48023
This page represents a class of proteins encompassing all the protein products of the FASLG gene in human.
Ontology Information
PRO ID PR:P48023 Show OBO stanza / PAF
PRO name tumor necrosis factor ligand superfamily member 6 (human)
Synonyms
PRO-short-label: EXACT: hFASLG
Gene-based: RELATED: APT1LG1 | CD95L | FASL | FASLG | TNFSF6
Other: EXACT: APTL (human) | CD178 (human) | CD95 ligand (human) | CD95-L (human) | Fas antigen ligand (human) | Fas ligand (human) | apoptosis antigen ligand (human)
Definition A tumor necrosis factor ligand superfamily member 6 that is encoded in the genome of human. [PRO:CNA, UniProtKB:P48023]
PRO Category organism-gene
Parent PR:000000095 tumor necrosis factor ligand superfamily member 6
Gene Template HGNC:11936 FASLG
Taxon NCBITaxon:9606 Homo sapiens
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Specific
Category Number of Terms
organism-gene 1
organism-sequence 3
organism-modification 2
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
PR:000036782
hFASLG/iso:FasL/var:F273L
Phe-275, CHEBI:30006
capable_of GO:0042802 identical protein binding with PR:000000278 FASLG/iso:FasL/var:F273L PMID:9405425
capable_of GO:0005102 signaling receptor binding with PR:P25445 hFAS PMID:9405425
located_in GO:0009986 cell surface PMID:9405425
PR:000036458
hFASLG/iso:FasL/NGlyco:1
Asn-184/Asn-250/Asn-260, MOD:00160
capable_of GO:0005102 signaling receptor binding PMID:9405425
participates_in GO:0097190 apoptotic signaling pathway PMID:9405425
PR:000036459
hFASLG/iso:FasL/Clv:soluble
capable_of GO:0005102 signaling receptor binding PMID:9405425
capable_of GO:0042802 identical protein binding PMID:7536672, PMID:9228058, PMID:9405425
located_in GO:0005615 extracellular space PMID:7536672
participates_in GO:0043066 negative regulation of apoptotic process PMID:9396774
PR:P48023-1
hFASLG/iso:FasL
participates_in GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling PMID:12761501
PR:000000095
FASLG
participates_in GO:0007267 cell-cell signaling PANTHER:PTHR11471:SF7
Molecular Function GO Term Protein Forms & Complexes Evidence
GO:0005102 signaling receptor binding PR:000036458 hFASLG/iso:FasL/NGlyco:1
Asn-184/Asn-250/Asn-260, MOD:00160
PMID:9405425
PR:000036459 hFASLG/iso:FasL/Clv:soluble

PMID:9405425
PR:000036782 hFASLG/iso:FasL/var:F273L
Phe-275, CHEBI:30006
with PR:P25445 hFAS
PMID:9405425
GO:0042802 identical protein binding PR:000036459 hFASLG/iso:FasL/Clv:soluble

PMID:7536672, PMID:9228058, PMID:9405425
PR:000036782 hFASLG/iso:FasL/var:F273L
Phe-275, CHEBI:30006
with PR:000000278 FASLG/iso:FasL/var:F273L
PMID:9405425
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0043066 negative regulation of apoptotic process PR:000036459 hFASLG/iso:FasL/Clv:soluble

PMID:9396774
GO:0007267 cell-cell signaling PR:000000095 FASLG

PANTHER:PTHR11471:SF7
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling PR:P48023-1 hFASLG/iso:FasL

PMID:12761501
GO:0097190 apoptotic signaling pathway PR:000036458 hFASLG/iso:FasL/NGlyco:1
Asn-184/Asn-250/Asn-260, MOD:00160
PMID:9405425
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0009986 cell surface PR:000036782 hFASLG/iso:FasL/var:F273L
Phe-275, CHEBI:30006
PMID:9405425
GO:0005615 extracellular space PR:000036459 hFASLG/iso:FasL/Clv:soluble

PMID:7536672

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