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Protein Ontology Report - hIRAK1

PR:P51617 - http://purl.obolibrary.org/obo/PR_P51617
This page represents a class of proteins encompassing all the protein products of the IRAK1 gene in Homo sapiens.
Ontology Information
PRO ID PR:P51617 Show OBO stanza / PAF / GPI
PRO name interleukin-1 receptor-associated kinase 1 (human)
Synonyms
PRO-short-label: EXACT: hIRAK1
Gene-based: RELATED: IRAK | IRAK1
Other: EXACT: IRAK-1 (human)
Definition An interleukin-1 receptor-associated kinase 1 that is encoded in the genome of human. [PRO:CNA]
PRO Category organism-gene
Parent PR:000001782 interleukin-1 receptor-associated kinase 1
Gene Template HGNC:6112 IRAK1
Taxon NCBITaxon:9606 Homo sapiens
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Specific
Category Number of Terms
organism-gene 1
organism-sequence 4
organism-modification 6
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

hIRAK1 forms found in complexes
hIRAK1 Component Complexes
PR:000027494 hIRAK1/iso:1/Phos:1 PR:000027495 pIRAK1:pIRAK4:MYD88:TIRAP:activated TLR4 (human)

Functional Annotation
PRO Term GO Annotation Evidence
PR:000027494
hIRAK1/iso:1/Phos:1
Thr-209, MOD:00047
enables GO:0005515 protein binding with PR:Q9NWZ3 hIRAK4 PMID:11960013
enables GO:0016301 kinase activity PMID:11960013
PR:000027495
pIRAK1:pIRAK4:MYD88:TIRAP:activated TLR4 (human)
acts_upstream_of_or_within GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894
PR:000027493
hIRAK1/iso:1/Phos:4
Thr-209/Thr-387, MOD:00047|MOD:00046
acts_upstream_of_or_within GO:0070498 interleukin-1-mediated signaling pathway PMID:14625308
enables GO:0004674 protein serine/threonine kinase activity PMID:14625308
enables NOT GO:0005515 protein binding with PR:Q99836 hMYD88 PMID:14625308
enables GO:0005515 protein binding with PR:Q9Y4K3 hTRAF6 PMID:14625308
PR:000027492
hIRAK1/iso:1/Phos:3
Thr-209/Thr-387, MOD:00047
acts_upstream_of_or_within GO:0070498 interleukin-1-mediated signaling pathway PMID:14625308
enables GO:0004674 protein serine/threonine kinase activity PMID:14625308
PR:P51617-1
hIRAK1/iso:1
acts_upstream_of_or_within GO:0070498 interleukin-1-mediated signaling pathway PMID:14625308
enables GO:0005515 protein binding with PR:Q9Y4K3 hTRAF6 PMID:14625308
enables GO:0005515 protein binding with PR:Q99836 hMYD88 PMID:14625308

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