Protein Ontology Report - hPLK1 PR:P53350 - http://purl.obolibrary.org/obo/PR_P53350

This page represents a class of proteins encompassing all the protein products of the PLK1 gene in Homo sapiens.

Ontology Information
PRO ID	PR:P53350 Show OBO stanza / PAF / GPI
PRO name	serine/threonine-protein kinase PLK1 (human)
Synonyms	PRO-short-label: EXACT: hPLK1 Gene-based: RELATED: PLK | PLK1 Other: EXACT: PLK-1 (human) | Polo-like kinase 1 (human) | STPK13 (human) BROAD: serine/threonine-protein kinase 13 (human)
Definition	A serine/threonine-protein kinase PLK1 that is encoded in the genome of human. [PMID:16129782, PMID:16580887, PMID:16760428, PMID:17376779, PMID:20624902, PMID:20823832, PRO:KER]
PRO Category	organism-gene
Parent	PR:000012870 serine/threonine-protein kinase PLK1
Gene Template	HGNC:9077 PLK1
Taxon	NCBITaxon:9606 Homo sapiens
Terms by PRO Category	Retrieve All terms OBO Stanza / PAF Organism-Specific Category Number of Terms organism-gene 1 organism-sequence 1 organism-modification 4
Term Hierarchy Visualization	DAG     OLS     Cytoscape

Related Cross References
DB identifiers	DTO:03100430, Reactome:R-HSA-156720, Reactome:R-HSA-164603, UniProtKB:P53350

Interactive Sequence View Select/align proteoforms across species

Protein Forms Display Category: All All organism-gene organism-sequence organism-modification
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

hPLK1 forms found in complexes
hPLK1 Component Complexes PR:P53350 hPLK1 PR:000035581 phosphoBUB1:PLK1 complex (human)

Functional Annotation PRO Centric View GO Centric View

PRO Term GO Annotation Evidence PR:000044818 hPLK1/Phos:1 Ser-99, MOD:00046|Thr-210, MOD:00047 acts_upstream_of_or_within GO:0007091 metaphase/anaphase transition of mitotic cell cycle PMID:23695676 enables GO:0071889 14-3-3 protein binding with PR:P61981 hYWHAG PMID:23695676 PR:P53350 hPLK1 acts_upstream_of_or_within GO:0034092 negative regulation of maintenance of sister chromatid cohesion PMID:16580887 acts_upstream_of_or_within NOT GO:0034501 protein localization to kinetochore PMID:16760428 acts_upstream_of_or_within NOT GO:0034501 protein localization to kinetochore PMID:16760428 acts_upstream_of_or_within GO:0034501 protein localization to kinetochore PMID:16760428 acts_upstream_of_or_within NOT GO:0031577 spindle checkpoint signaling PMID:16760428 acts_upstream_of_or_within GO:0051310 metaphase plate congression PMID:17376779 acts_upstream_of_or_within GO:0008608 attachment of spindle microtubules to kinetochore PMID:17376779 enables GO:0005515 protein binding with PR:O14641 hDVL2 PMID:20823832 enables GO:0005515 protein binding with PR:Q5FBB7 hSGO1 BioGRID:BG-338598 enables GO:0005515 protein binding with PR:O60566 hBUB1B PMID:17376779 enables GO:0005515 protein binding with PR:O43683 hBUB1 BioGRID:BG-718371 enables GO:0004672 protein kinase activity PMID:16760428 located_in GO:0000776 kinetochore PMID:20624902 located_in GO:0005813 centrosome PMID:16760428 located_in GO:0000922 spindle pole PMID:20823832 located_in GO:0000940 outer kinetochore PMID:16760428 Cellular Location GO Term Protein Forms & Complexes Evidence GO:0000940 outer kinetochore PR:P53350 hPLK1 PMID:16760428 GO:0005813 centrosome PR:P53350 hPLK1 PMID:16760428 GO:0000922 spindle pole PR:P53350 hPLK1 PMID:20823832 GO:0000776 kinetochore PR:P53350 hPLK1 PMID:20624902

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