Protein Ontology Report - hSMAD3 PR:P84022 - http://purl.obolibrary.org/obo/PR_P84022

This page represents a class of proteins encompassing all the protein products of the SMAD3 gene in Homo sapiens.

Ontology Information
PRO ID	PR:P84022 Show OBO stanza / PAF / GPI
PRO name	mothers against decapentaplegic homolog 3 (human)
Synonyms	PRO-short-label: EXACT: hSMAD3 Gene-based: RELATED: MADH3 | SMAD3 Other: EXACT: JV15-2 (human) | MAD homolog 3 (human) | Mad3 (human) | SMAD 3 (human) | SMAD family member 3 (human) | Smad3 (human) | hMAD-3 | mothers against DPP homolog 3 (human)
Definition	A smad3 that is encoded in the genome of human.
PRO Category	organism-gene
Parent	PR:000000365 smad3
Gene Template	HGNC:6769 SMAD3
Taxon	NCBITaxon:9606 Homo sapiens
Terms by PRO Category	Retrieve All terms OBO Stanza / PAF Organism-Specific Category Number of Terms organism-gene 1 organism-sequence 4 organism-modification 5
Term Hierarchy Visualization	DAG     OLS     Cytoscape

Related Cross References
DB identifiers	Reactome:R-HSA-170855, Reactome:R-HSA-206150, UniProtKB:P84022

Interactive Sequence View Select/align proteoforms across species

Protein Forms Display Category: All All organism-gene organism-sequence organism-modification
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation PRO Centric View GO Centric View

PRO Term GO Annotation Evidence PR:000036557 hSMAD3/iso:1/AcPhos:1 Lys-19, MOD:00064|Ser-423/Ser-425, MOD:00046 acts_upstream_of_or_within GO:0007179 transforming growth factor beta receptor signaling pathway PMID:17074756 enables GO:0003700 DNA-binding transcription factor activity PMID:17074756 located_in GO:0005634 nucleus PMID:17074756 PR:P84022-1 hSMAD3/iso:1 acts_upstream_of_or_within GO:0007179 transforming growth factor beta receptor signaling pathway PMID:8774881 enables GO:0005515 protein binding with PR:000025959 hTGFBR1/iso:1/SigPep-/Phos:1 PMID:12154125 enables GO:0005515 protein binding with PR:O95405-1 hZFYVE9/iso:1 PMID:12154125 located_in GO:0005737 cytoplasm PMID:17074053 PR:000026333 hSMAD3/iso:1/Phos:1 Ser-423/Ser-425, MOD:00046 acts_upstream_of_or_within GO:0006366 transcription by RNA polymerase II PMID:10823886 acts_upstream_of_or_within GO:0007179 transforming growth factor beta receptor signaling pathway PMID:8774881, PMID:9380693 enables GO:0008134 transcription factor binding PMID:15084259 enables GO:0046332 SMAD binding with PR:Q13485 hSMAD4 PMID:15350224, PMID:9311995 enables GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific PMID:10823886, PMID:12943993 located_in GO:0005634 nucleus PMID:10846168, PMID:15280432 part_of GO:0005667 transcription factor complex PMID:12374795 Cellular Location GO Term Protein Forms & Complexes Evidence GO:0005634 nucleus PR:000026333 hSMAD3/iso:1/Phos:1 Ser-423/Ser-425, MOD:00046 PMID:10846168, PMID:15280432 PR:000036557 hSMAD3/iso:1/AcPhos:1 Lys-19, MOD:00064|Ser-423/Ser-425, MOD:00046 PMID:17074756 GO:0005737 cytoplasm PR:P84022-1 hSMAD3/iso:1 PMID:17074053

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