Protein Ontology Report - hBTK PR:Q06187 - http://purl.obolibrary.org/obo/PR_Q06187

This page represents a class of proteins encompassing all the protein products of the BTK gene in Homo sapiens.

Ontology Information
PRO ID	PR:Q06187 Show OBO stanza / PAF / GPI
PRO name	tyrosine-protein kinase BTK (human)
Synonyms	PRO-short-label: EXACT: hBTK Gene-based: RELATED: AGMX1 | ATK | BPK | BTK Other: EXACT: B-cell progenitor kinase (human) | agammaglobulinemia tyrosine kinase (human) | bruton tyrosine kinase (human)
Definition	A tyrosine-protein kinase BTK that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q06187]
PRO Category	organism-gene
Parent	PR:000002110 tyrosine-protein kinase BTK
Gene Template	HGNC:1133 BTK
Taxon	NCBITaxon:9606 Homo sapiens
Terms by PRO Category	Retrieve All terms OBO Stanza / PAF Organism-Specific Category Number of Terms organism-gene 1 organism-sequence 2 organism-modification 4
Term Hierarchy Visualization	DAG     OLS     Cytoscape

Related Cross References
DB identifiers	DTO:03100050, UniProtKB:Q06187

Interactive Sequence View Select/align proteoforms across species

Protein Forms Display Category: All All organism-gene organism-sequence organism-modification
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

hBTK forms found in complexes
hBTK Component Complexes PR:000044351 hBTK/InitMet- PR:000037448 pTIRAP:PIP2:BTK:activated TLR4 complex (human) PR:000044351 hBTK/InitMet- PR:000037446 MYD88:TIRAP:PIP2:BTK:activated TLR4 complex (human) PR:000044351 hBTK/InitMet- PR:000037447 TIRAP:PIP2:BTK:activated TLR4 complex (human)

Functional Annotation PRO Centric View GO Centric View

PRO Term GO Annotation Evidence PR:000037448 pTIRAP:PIP2:BTK:activated TLR4 complex (human) acts_upstream_of_or_within GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_125282 acts_upstream_of_or_within GO:0002755 MyD88-dependent toll-like receptor signaling pathway Reactome:REACT_125282 located_in GO:0005886 plasma membrane Reactome:REACT_125282 PR:000037447 TIRAP:PIP2:BTK:activated TLR4 complex (human) acts_upstream_of_or_within GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_120882 acts_upstream_of_or_within GO:0002755 MyD88-dependent toll-like receptor signaling pathway Reactome:REACT_120882 enables GO:0004713 protein tyrosine kinase activity Reactome:REACT_120882 located_in GO:0005886 plasma membrane Reactome:REACT_120882 Cellular Location GO Term Protein Forms & Complexes Evidence GO:0005886 plasma membrane PR:000037447 TIRAP:PIP2:BTK:activated TLR4 complex (human) Reactome:REACT_120882 PR:000037448 pTIRAP:PIP2:BTK:activated TLR4 complex (human) Reactome:REACT_125282

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