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Protein Ontology Report - hFADD

PR:Q13158 - http://purl.obolibrary.org/obo/PR_Q13158
This page represents a class of proteins encompassing all the protein products of the FADD gene in Homo sapiens.
Ontology Information
PRO ID PR:Q13158 Show OBO stanza / PAF / GPI
PRO name FAS-associated death domain protein (human)
Synonyms
PRO-short-label: EXACT: hFADD
Gene-based: RELATED: FADD | GIG3 | MORT1
Other: EXACT: FAS-associating death domain-containing protein (human) | growth-inhibiting gene 3 protein (human) | mediator of receptor induced toxicity (human)
Definition A FAS-associated death domain protein that is encoded in the genome of human. [PRO:DNx]
PRO Category organism-gene
Parent PR:000002189 FAS-associated death domain protein
Gene Template HGNC:3573 FADD
Taxon NCBITaxon:9606 Homo sapiens
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Specific
Category Number of Terms
organism-gene 1
organism-sequence 1
organism-modification 1
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

hFADD forms found in complexes
hFADD Component Complexes
PR:Q13158 hFADD PR:000037366 fadd:rip1:ticam1:activated TLR3 complex (human)
PR:Q13158 hFADD PR:000036060 pro-caspase-8:fadd:rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:Q13158 hFADD PR:000037368 pro-caspase-8:fadd:rip1:ticam1:activated TLR3 complex (human)
PR:Q13158 hFADD PR:000028435 TRADD:TRAF2:RIP1:FADD:caspase-8 complex (human)
PR:Q13158 hFADD PR:000028437 TRAF2:TRADD:RIP1:FADD (human)

Functional Annotation
PRO Term GO Annotation Evidence
PR:000037366
fadd:rip1:ticam1:activated TLR3 complex (human)
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
located_in GO:0010008 endosome membrane Reactome:REACT_6783
PR:000036060
pro-caspase-8:fadd:rip1:ticam1:ticam2:activated TLR4 complex (human)
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
enables GO:0004197 cysteine-type endopeptidase activity Reactome:REACT_151344
located_in GO:0010008 endosome membrane Reactome:REACT_151344
PR:000037368
pro-caspase-8:fadd:rip1:ticam1:activated TLR3 complex (human)
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
located_in GO:0010008 endosome membrane Reactome:REACT_6783
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0010008 endosome membrane PR:000036060 pro-caspase-8:fadd:rip1:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_151344
PR:000037366 fadd:rip1:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037368 pro-caspase-8:fadd:rip1:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783

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