back to PRO homepage
  Home |   Linked Open Data |   Browse |   Search |   Statistics |   Download
 RACE-PRO
 PRO tracker
 Community
 PRO Consortium
 Publications
 Documentation

Protein Ontology Report - hTAB1

PR:Q15750 - http://purl.obolibrary.org/obo/PR_Q15750
This page represents a class of proteins encompassing all the protein products of the TAB1 gene in human.
Ontology Information
PRO ID PR:Q15750 Show OBO stanza / PAF / GPI
PRO name TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (human)
Synonyms
PRO-short-label: EXACT: hTAB1
Gene-based: RELATED: MAP3K7IP1 | TAB1
Other: EXACT: TAK1-binding protein 1 (human) | TGF-beta-activated kinase 1-binding protein 1 (human) | mitogen-activated protein kinase kinase kinase 7-interacting protein 1 (human)
Definition A TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 that is encoded in the genome of human. [PRO:CNA]
PRO Category organism-gene
Parent PR:000001770 TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
Gene Template HGNC:18157 TAB1
Taxon NCBITaxon:9606 Homo sapiens
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Specific
Category Number of Terms
organism-gene 1
organism-sequence 2
organism-modification 0
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

hTAB1 forms found in complexes
hTAB1 Component Complexes
PR:Q15750 hTAB1 PR:000035740 free K63-linked pUb:activated TAK1 complex:pUbtraf6 complex (human)
PR:Q15750 hTAB1 PR:000035738 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
PR:Q15750 hTAB1 PR:000037338 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:activated TLR3 complex (human)
PR:Q15750 hTAB1 PR:000035730 TAK1 kinase complex (human)
PR:Q15750 hTAB1 PR:000037342 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:activated TLR3 complex (human)
PR:Q15750 hTAB1 PR:000035734 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)

Functional Annotation
PRO Term GO Annotation Evidence
PR:000037338
free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:activated TLR3 complex (human)
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
located_in GO:0010008 endosome membrane Reactome:REACT_6783
PR:000035738
free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
located_in GO:0010008 endosome membrane Reactome:REACT_26039
PR:000035734
free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
enables GO:0004674 protein serine/threonine kinase activity Reactome:REACT_26036
located_in GO:0010008 endosome membrane Reactome:REACT_26036
PR:000037342
free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:activated TLR3 complex (human)
acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
located_in GO:0010008 endosome membrane Reactome:REACT_6783
PR:000035730
TAK1 kinase complex (human)
acts_upstream_of_or_within GO:0038095 Fc-epsilon receptor signaling pathway Reactome:REACT_163936
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
acts_upstream_of_or_within GO:0002755 MyD88-dependent toll-like receptor signaling pathway Reactome:REACT_25222
PR:000035740
free K63-linked pUb:activated TAK1 complex:pUbtraf6 complex (human)
acts_upstream_of_or_within GO:0002755 MyD88-dependent toll-like receptor signaling pathway Reactome:REACT_23131
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_23131
located_in GO:0005829 cytosol Reactome:REACT_23131
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005829 cytosol PR:000035740 free K63-linked pUb:activated TAK1 complex:pUbtraf6 complex (human)

Reactome:REACT_23131
GO:0010008 endosome membrane PR:000035734 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_26036
PR:000035738 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_26039
PR:000037338 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037342 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783

top