Protein Ontology Report - hTAB1 PR:Q15750 - http://purl.obolibrary.org/obo/PR_Q15750

This page represents a class of proteins encompassing all the protein products of the TAB1 gene in Homo sapiens.

Ontology Information
PRO ID	PR:Q15750 Show OBO stanza / PAF / GPI
PRO name	TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (human)
Synonyms	PRO-short-label: EXACT: hTAB1 Gene-based: RELATED: MAP3K7IP1 | TAB1 Other: EXACT: TAK1-binding protein 1 (human) | TGF-beta-activated kinase 1-binding protein 1 (human) | mitogen-activated protein kinase kinase kinase 7-interacting protein 1 (human)
Definition	A TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 that is encoded in the genome of human. [PRO:CNA]
PRO Category	organism-gene
Parent	PR:000001770 TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
Gene Template	HGNC:18157 TAB1
Taxon	NCBITaxon:9606 Homo sapiens
Terms by PRO Category	Retrieve All terms OBO Stanza / PAF Organism-Specific Category Number of Terms organism-gene 1 organism-sequence 2 organism-modification 0
Term Hierarchy Visualization	DAG     OLS     Cytoscape

Related Cross References
DB identifiers	DTO:03100512, Reactome:R-HSA-167923, Reactome:R-HSA-450238, UniProtKB:Q15750

Interactive Sequence View Select/align proteoforms across species

Protein Forms Display Category: All All organism-gene organism-sequence
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

hTAB1 forms found in complexes

hTAB1 Component Complexes PR:Q15750 hTAB1 PR:000037342 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:activated TLR3 complex (human) PR:Q15750 hTAB1 PR:000037338 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:activated TLR3 complex (human) PR:Q15750 hTAB1 PR:000035730 TAK1 kinase complex (human) PR:Q15750 hTAB1 PR:000035738 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human) PR:Q15750 hTAB1 PR:000035734 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human) PR:Q15750 hTAB1 PR:000035740 free K63-linked pUb:activated TAK1 complex:pUbtraf6 complex (human)

Functional Annotation PRO Centric View GO Centric View

PRO Term GO Annotation Evidence PR:000037338 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:activated TLR3 complex (human) acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783 acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783 located_in GO:0010008 endosome membrane Reactome:REACT_6783 PR:000035738 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human) acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809 located_in GO:0010008 endosome membrane Reactome:REACT_26039 PR:000035734 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human) acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809 enables GO:0004674 protein serine/threonine kinase activity Reactome:REACT_26036 located_in GO:0010008 endosome membrane Reactome:REACT_26036 PR:000037342 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:activated TLR3 complex (human) acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783 acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783 located_in GO:0010008 endosome membrane Reactome:REACT_6783 PR:000035730 TAK1 kinase complex (human) acts_upstream_of_or_within GO:0038095 Fc-epsilon receptor signaling pathway Reactome:REACT_163936 acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809 acts_upstream_of_or_within GO:0002755 MyD88-dependent toll-like receptor signaling pathway Reactome:REACT_25222 PR:000035740 free K63-linked pUb:activated TAK1 complex:pUbtraf6 complex (human) acts_upstream_of_or_within GO:0002755 MyD88-dependent toll-like receptor signaling pathway Reactome:REACT_23131 acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_23131 located_in GO:0005829 cytosol Reactome:REACT_23131 Cellular Location GO Term Protein Forms & Complexes Evidence GO:0005829 cytosol PR:000035740 free K63-linked pUb:activated TAK1 complex:pUbtraf6 complex (human) Reactome:REACT_23131 GO:0010008 endosome membrane PR:000035734 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_26036 PR:000035738 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_26039 PR:000037338 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037342 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:activated TLR3 complex (human) Reactome:REACT_6783

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