Protein Ontology Report - mSMAD3 PR:Q8BUN5 - http://purl.obolibrary.org/obo/PR_Q8BUN5

This page represents a class of proteins encompassing all the protein products of the Smad3 gene in Mus musculus.

Ontology Information
PRO ID	PR:Q8BUN5 Show OBO stanza / PAF / GPI
PRO name	mothers against decapentaplegic homolog 3 (mouse)
Synonyms	PRO-short-label: EXACT: mSMAD3 Gene-based: RELATED: Madh3 | Smad3 Other: EXACT: MAD homolog 3 (mouse) | SMAD 3 (mouse) | SMAD family member 3 (mouse) | mMad3 | mothers against DPP homolog 3 (mouse) RELATED: Mad3 (mouse)
Definition	A smad3 that is encoded in the genome of mouse. [OMA:Q8BUN5, PRO:DNx]
PRO Category	organism-gene
Parent	PR:000000365 smad3
Gene Template	MGI:1201674 Smad3
Taxon	NCBITaxon:10090 Mus musculus
Terms by PRO Category	Retrieve All terms OBO Stanza / PAF Organism-Specific Category Number of Terms organism-gene 1 organism-sequence 1 organism-modification 3
Term Hierarchy Visualization	DAG     OLS     Cytoscape

Related Cross References
DB identifiers	UniProtKB:Q8BUN5

Interactive Sequence View Select/align proteoforms across species

Protein Forms Display Category: All All organism-gene organism-sequence organism-modification
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation PRO Centric View GO Centric View

PRO Term GO Annotation Evidence PR:000036560 mSMAD3/iso:1/Phos:2 Thr-8/Thr-179, MOD:00047|Ser-213, MOD:00046 enables GO:0003700 DNA-binding transcription factor activity decreased relative to PR:000036558 mSMAD3/iso:1/Phos:1 PMID:15241418 PR:000036561 mSMAD3/iso:1/Phos:3 Thr-179, MOD:00047|Ser-204/Ser-208/Ser-213, MOD:00046 enables NOT GO:0003713 transcription coactivator activity PMID:10197981 located_in GO:0005737 cytoplasm PMID:10197981 PR:Q8BUN5-1 mSMAD3/iso:1 acts_upstream_of_or_within GO:0007179 transforming growth factor beta receptor signaling pathway PMID:12543979 enables GO:0005515 protein binding with PR:A2A8R0 mZFYVE9/iso:1 PMID:12154125 enables GO:0005515 protein binding with PR:000036434 mTGFBR1/iso:1/SigPep-/Phos:1 PMID:12154125 PR:000036558 mSMAD3/iso:1/Phos:1 Ser-423/Ser-425, MOD:00046 enables GO:0003690 double-stranded DNA binding PMID:15282343 enables GO:0008134 transcription factor binding PMID:15464984, PMID:9702197 enables GO:0003700 DNA-binding transcription factor activity PMID:10823886, PMID:12943993 located_in GO:0005634 nucleus PMID:12943993, PMID:15282343 part_of GO:0005667 transcription factor complex PMID:9702197 Cellular Location GO Term Protein Forms & Complexes Evidence GO:0005634 nucleus PR:000036558 mSMAD3/iso:1/Phos:1 Ser-423/Ser-425, MOD:00046 PMID:12943993, PMID:15282343 GO:0005737 cytoplasm PR:000036561 mSMAD3/iso:1/Phos:3 Thr-179, MOD:00047|Ser-204/Ser-208/Ser-213, MOD:00046 PMID:10197981

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