Protein Ontology Report - hSIAH1 PR:Q8IUQ4 - http://purl.obolibrary.org/obo/PR_Q8IUQ4

This page represents a class of proteins encompassing all the protein products of the SIAH1 gene in Homo sapiens.

Ontology Information
PRO ID	PR:Q8IUQ4 Show OBO stanza / PAF / GPI
PRO name	E3 ubiquitin-protein ligase SIAH1 (human)
Synonyms	PRO-short-label: EXACT: hSIAH1 Gene-based: RELATED: HUMSIAH | SIAH1 Other: EXACT: RING-type E3 ubiquitin transferase SIAH1 (human) | Siah-1 (human) | Siah-1a (human) | seven in absentia homolog 1 (human)
Definition	An E3 ubiquitin-protein ligase SIAH1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IUQ4]
PRO Category	organism-gene
Parent	PR:000014860 E3 ubiquitin-protein ligase SIAH1
Gene Template	HGNC:10857 SIAH1
Taxon	NCBITaxon:9606 Homo sapiens
Terms by PRO Category	Retrieve All terms OBO Stanza / PAF Organism-Specific Category Number of Terms organism-gene 1 organism-sequence 3 organism-modification 2
Term Hierarchy Visualization	DAG     OLS     Cytoscape

Related Cross References
DB identifiers	Reactome:R-HSA-374563, UniProtKB:Q8IUQ4

Interactive Sequence View Select/align proteoforms across species

Protein Forms Display Category: All All organism-gene organism-sequence organism-modification
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation PRO Centric View GO Centric View

PRO Term GO Annotation Evidence PR:000025641 hSIAH1/iso:1/Phos:1 Tyr-100/Tyr-126, MOD:00048 acts_upstream_of_or_within GO:0070304 positive regulation of stress-activated protein kinase signaling cascade PMID:16230351 acts_upstream_of_or_within GO:0043525 positive regulation of neuron apoptotic process PMID:16230351 enables GO:0005515 protein binding increased relative to PR:000045369 hSIAH1/iso:1/UnPhos:1 with PR:Q69ZI1-1 mSH3RF1/iso:1 PMID:16230351 PR:000045369 hSIAH1/iso:1/UnPhos:1 Tyr-100/Tyr-126, PR:000026291 acts_upstream_of_or_within GO:0070304 positive regulation of stress-activated protein kinase signaling cascade PMID:16230351 acts_upstream_of_or_within GO:0043525 positive regulation of neuron apoptotic process PMID:16230351 enables GO:0005515 protein binding with PR:Q69ZI1 mSH3RF1 PMID:16230351

top