PRO Entry Report - PR:Q8R104

This page represents a class of proteins encompassing all the protein products of the Sirt3 gene in Mus musculus.

Protein Forms Annotations

Ontology Information

PRO ID

PR:Q8R104 Show OBO stanza / PAF / GPI

PRO name

NAD-dependent protein deacetylase sirtuin-3 (mouse)

Synonyms

PRO-short-label:	EXACT:	mSIRT3
Gene-based:	RELATED:	Sir2l3 \| Sirt3
Other:	EXACT:	SIR2-like protein 3 (mouse) \| mSIR2L3 \| regulatory protein SIR2 homolog 3 (mouse)

Definition

An NAD-dependent protein deacetylase sirtuin-3, mitochondrial that is encoded in the genome of mouse. [OMA:Q8R104, PRO:DNx]

PRO Category

organism-gene

Parent

PR:000029756 NAD-dependent protein deacetylase sirtuin-3, mitochondrial

Gene Template

Taxon

Terms by PRO Category

Retrieve All terms OBO Stanza / PAF

Term Hierarchy Visualization

DAG

OLS

Related Cross References
DB identifiers	UniProtKB:Q8R104

Interactive Sequence View Select/align proteoforms across species

Protein Forms

PRO ID & Category Annotation Complex	Name	Short Label	Definition & Comment

Functional Annotation

PRO Term	GO Annotation		Evidence
PR:Q8R104-1 mSIRT3/iso:1	acts_upstream_of_or_within	GO:0006476 protein deacetylation	MGI:4830236, PMID:19241369
	enables	GO:0032041 NAD-dependent histone H3K14 deacetylase activity	MGI:4830236, PMID:19241369
	located_in	GO:0005739 mitochondrion	MGI:4830236, PMID:19241369
PR:Q8R104-2 mSIRT3/iso:2	enables	NOT GO:0032041 NAD-dependent histone H3K14 deacetylase activity	MGI:1926994, PMID:11056054
PR:Q8R104-2 mSIRT3/iso:2	located_in	GO:0005737 cytoplasm	MGI:1926994, PMID:11056054

Cellular Location GO Term	Protein Forms & Complexes	Evidence
GO:0005737 cytoplasm	PR:Q8R104-2 mSIRT3/iso:2	MGI:1926994, PMID:11056054
GO:0005739 mitochondrion	PR:Q8R104-1 mSIRT3/iso:1	MGI:4830236, PMID:19241369

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