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Protein Ontology Report - mTIRAP

PR:Q99JY1 -
This page represents a class of proteins encompassing all the protein products of the Tirap gene in Mus musculus.
Ontology Information
PRO ID PR:Q99JY1 Show OBO stanza / PAF / GPI
PRO name Toll/interleukin-1 receptor domain-containing adapter protein (mouse)
PRO-short-label: EXACT: mTIRAP
Gene-based: RELATED: Mal | Tirap
Other: EXACT: MyD88 adapter-like protein (mouse) | TIR domain-containing adapter protein (mouse) | adaptor protein Wyatt (mouse)
Definition A Toll/interleukin-1 receptor domain-containing adapter protein that is encoded in the genome of mouse. [OMA:Q99JY1, PRO:CNA]
PRO Category organism-gene
Parent PR:000001751 Toll/interleukin-1 receptor domain-containing adapter protein
Gene Template MGI:2152213 Tirap
Taxon NCBITaxon:10090 Mus musculus
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Category Number of Terms
organism-gene 1
organism-sequence 0
organism-modification 1
Term Hierarchy Visualization DAG     OLS     Cytoscape

Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

mTIRAP forms found in complexes
mTIRAP Component Complexes
PR:000001751 TIRAP PR:000025784 MYD88:TIRAP:activated TLR4 receptor
PR:000001751 TIRAP PR:000036006 TIRAP:PIP2 complex
PR:000001751 TIRAP PR:000027182 IRAK4:MYD88:TIRAP:activated TLR4 complex
PR:000027216 mTIRAP/Phos:1 PR:000027217 pTIRAP:PIP2:activated TLR4 complex (mouse)
PR:000027216 mTIRAP/Phos:1 PR:000037478 pTIRAP:PIP2:BTK:activated TLR4 complex (mouse)
PR:Q99JY1 mTIRAP PR:000027174 MYD88s:TIRAP:activated TLR4 receptor (mouse)
PR:Q99JY1 mTIRAP PR:000036007 TIRAP:PIP2 complex (mouse)
PR:Q99JY1 mTIRAP PR:000037481 MYD88:TIRAP:PIP2:BTK:activated TLR4 complex (mouse)
PR:Q99JY1 mTIRAP PR:000037477 TIRAP:PIP2:BTK:activated TLR4 complex (mouse)
PR:Q99JY1 mTIRAP PR:000027175 MYD88l:TIRAP:activated TLR4 receptor (mouse)
PR:Q99JY1 mTIRAP PR:000027187 IRAK4:MYD88:TIRAP:activated TLR4 complex (mouse)
PR:Q99JY1 mTIRAP PR:000027196 TIRAP:PIP2:activated TLR4 (mouse)
PR:Q99JY1 mTIRAP PR:000027220 IRAK1:IRAK4:MYD88:TIRAP:activated TLR4 (mouse)
PR:Q99JY1 mTIRAP PR:000027267 IRAK3:IRAK1:IRAK4:MYD88:TIRAP:activated TLR4 (mouse)
PR:Q99JY1 mTIRAP PR:000027221 pIRAK1:IRAK4:MYD88:TIRAP:activated TLR4 (mouse)

Functional Annotation
PRO Term GO Annotation Evidence
TIRAP:PIP2 complex (mouse)
acts_upstream_of_or_within GO:0002755 MyD88-dependent toll-like receptor signaling pathway PMID:11544529
TIRAP:PIP2:activated TLR4 (mouse)
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway PMID:12447442
MYD88s:TIRAP:activated TLR4 receptor (mouse)
acts_upstream_of_or_within GO:0034125 negative regulation of MyD88-dependent toll-like receptor signaling pathway PMID:12538665