Protein Ontology Report - hLY96 PR:Q9Y6Y9 - http://purl.obolibrary.org/obo/PR_Q9Y6Y9

This page represents a class of proteins encompassing all the protein products of the LY96 gene in Homo sapiens.

Ontology Information
PRO ID	PR:Q9Y6Y9 Show OBO stanza / PAF / GPI
PRO name	lymphocyte antigen 96 (human)
Synonyms	PRO-short-label: EXACT: hLY96 Gene-based: RELATED: ESOP1 | LY96 | MD2 Other: EXACT: ESOP-1 (human) | Ly-96 (human) | protein MD-2 (human)
Definition	A lymphocyte antigen 96 that is encoded in the genome of human. [TLR:AMM, UniProtKB:Q9Y6Y9]
PRO Category	organism-gene
Parent	PR:000003296 lymphocyte antigen 96
Gene Template	HGNC:17156 LY96
Taxon	NCBITaxon:9606 Homo sapiens
Terms by PRO Category	Retrieve All terms OBO Stanza / PAF Organism-Specific Category Number of Terms organism-gene 1 organism-sequence 2 organism-modification 2
Term Hierarchy Visualization	DAG     OLS     Cytoscape

Related Cross References
DB identifiers	UniProtKB:Q9Y6Y9

Interactive Sequence View Select/align proteoforms across species

Protein Forms Display Category: All All organism-gene organism-sequence organism-modification
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

hLY96 forms found in complexes

hLY96 Component Complexes PR:000003296 LY96 PR:000025784 MYD88:TIRAP:activated TLR4 receptor PR:000003296 LY96 PR:000036076 activated TLR4 complex PR:000003296 LY96 PR:000036003 LY96:TLR4 complex PR:000003296 LY96 PR:000027182 IRAK4:MYD88:TIRAP:activated TLR4 complex PR:000025786 hLY96/iso:1/SigPep-/NGlyco:1 PR:000027183 IRAK4:MYD88:TIRAP:activated TLR4 complex (human) PR:000025786 hLY96/iso:1/SigPep-/NGlyco:1 PR:000036060 pro-caspase-8:fadd:rip1:ticam1:ticam2:activated TLR4 complex (human) PR:000025786 hLY96/iso:1/SigPep-/NGlyco:1 PR:000036058 rip1:rip3:ticam1:ticam2:activated TLR4 complex (human) PR:000025786 hLY96/iso:1/SigPep-/NGlyco:1 PR:000036056 rip3:ticam1:ticam2:activated TLR4 complex (human) PR:000025786 hLY96/iso:1/SigPep-/NGlyco:1 PR:000036053 IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human) PR:000025786 hLY96/iso:1/SigPep-/NGlyco:1 PR:000036049 K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human) PR:000025786 hLY96/iso:1/SigPep-/NGlyco:1 PR:000036041 K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human) PR:000025786 hLY96/iso:1/SigPep-/NGlyco:1 PR:000036038 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human) PR:000025786 hLY96/iso:1/SigPep-/NGlyco:1 PR:000036036 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human) PR:000025786 hLY96/iso:1/SigPep-/NGlyco:1 PR:000036034 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human) PR:000025786 hLY96/iso:1/SigPep-/NGlyco:1 PR:000036030 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human) PR:000025786 hLY96/iso:1/SigPep-/NGlyco:1 PR:000044684 activated TLR4 complex (human) PR:000025786 hLY96/iso:1/SigPep-/NGlyco:1 PR:000028680 traf6:ticam1:ticam2:activated TLR4 complex (human) PR:000025786 hLY96/iso:1/SigPep-/NGlyco:1 PR:000028678 ticam2:activated TLR4 complex (human) PR:000025786 hLY96/iso:1/SigPep-/NGlyco:1 PR:000036027 sarm:ticam1:ticam2:activated TLR4 complex (human) PR:000025786 hLY96/iso:1/SigPep-/NGlyco:1 PR:000036024 rip1:ticam1:ticam2:activated TLR4 complex (human) PR:000025786 hLY96/iso:1/SigPep-/NGlyco:1 PR:000036022 traf3:ticam1:ticam2:activated TLR4 complex (human) PR:000025786 hLY96/iso:1/SigPep-/NGlyco:1 PR:000036004 LY96:TLR4 complex (human) PR:000025786 hLY96/iso:1/SigPep-/NGlyco:1 PR:000036135 TIRAP:PIP2:activated TLR4 complex (human) PR:000025786 hLY96/iso:1/SigPep-/NGlyco:1 PR:000035738 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human) PR:000025786 hLY96/iso:1/SigPep-/NGlyco:1 PR:000035734 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human) PR:000025786 hLY96/iso:1/SigPep-/NGlyco:1 PR:000035715 pUbtraf6:ticam1:ticam2:activated TLR4 complex (human) PR:000025786 hLY96/iso:1/SigPep-/NGlyco:1 PR:000037479 lipopolysaccharide receptor complex 4 (human) PR:000025786 hLY96/iso:1/SigPep-/NGlyco:1 PR:000037448 pTIRAP:PIP2:BTK:activated TLR4 complex (human) PR:000025786 hLY96/iso:1/SigPep-/NGlyco:1 PR:000037447 TIRAP:PIP2:BTK:activated TLR4 complex (human) PR:000025786 hLY96/iso:1/SigPep-/NGlyco:1 PR:000037446 MYD88:TIRAP:PIP2:BTK:activated TLR4 complex (human) PR:000025786 hLY96/iso:1/SigPep-/NGlyco:1 PR:000036124 p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human) PR:000025786 hLY96/iso:1/SigPep-/NGlyco:1 PR:000036123 p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human) PR:000025786 hLY96/iso:1/SigPep-/NGlyco:1 PR:000027192 pIRAK4:MYD88:TIRAP:activated TLR4 complex (human) PR:000025786 hLY96/iso:1/SigPep-/NGlyco:1 PR:000027208 ticam1:ticam2:activated TLR4 complex (human) PR:000025786 hLY96/iso:1/SigPep-/NGlyco:1 PR:000025773 lipopolysaccharide receptor complex 3 (human) PR:000025786 hLY96/iso:1/SigPep-/NGlyco:1 PR:000027495 pIRAK1:pIRAK4:MYD88:TIRAP:activated TLR4 (human) PR:000025786 hLY96/iso:1/SigPep-/NGlyco:1 PR:000027218 pTIRAP:PIP2:activated TLR4 complex (human)

Functional Annotation PRO Centric View GO Centric View

PRO Term GO Annotation Evidence PR:000036041 K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human) acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809 located_in GO:0010008 endosome membrane Reactome:REACT_124855 PR:000035715 pUbtraf6:ticam1:ticam2:activated TLR4 complex (human) acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809 located_in GO:0010008 endosome membrane Reactome:REACT_25867 PR:000027495 pIRAK1:pIRAK4:MYD88:TIRAP:activated TLR4 (human) acts_upstream_of_or_within GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894 PR:000025773 lipopolysaccharide receptor complex 3 (human) acts_upstream_of_or_within GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894 PR:000037448 pTIRAP:PIP2:BTK:activated TLR4 complex (human) acts_upstream_of_or_within GO:0002755 MyD88-dependent toll-like receptor signaling pathway Reactome:REACT_125282 acts_upstream_of_or_within GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_125282 located_in GO:0005886 plasma membrane Reactome:REACT_125282 PR:000036124 p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human) acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809 located_in GO:0010008 endosome membrane Reactome:REACT_26959 PR:000028678 ticam2:activated TLR4 complex (human) acts_upstream_of_or_within GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6809 acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809 located_in GO:0010008 endosome membrane Reactome:REACT_7083 PR:000037447 TIRAP:PIP2:BTK:activated TLR4 complex (human) acts_upstream_of_or_within GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_120882 acts_upstream_of_or_within GO:0002755 MyD88-dependent toll-like receptor signaling pathway Reactome:REACT_120882 enables GO:0004713 protein tyrosine kinase activity Reactome:REACT_120882 located_in GO:0005886 plasma membrane Reactome:REACT_120882 PR:000036034 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human) acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809 enables GO:0004674 protein serine/threonine kinase activity Reactome:REACT_27000 located_in GO:0010008 endosome membrane Reactome:REACT_27000 PR:000025786 hLY96/iso:1/SigPep-/NGlyco:1 Asn-26/Asn-114, MOD:00160 enables GO:0001530 lipopolysaccharide binding PMID:17569869 enables GO:1990458 lipooligosaccharide binding PMID:19783674 located_in GO:0005886 plasma membrane Reactome:REACT_7660 located_in GO:0005615 extracellular space PMID:19783674 located_in GO:0005615 extracellular space PMID:11593030 PR:000027208 ticam1:ticam2:activated TLR4 complex (human) acts_upstream_of_or_within GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6809 acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809 located_in GO:0010008 endosome membrane Reactome:REACT_7861 PR:000036053 IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human) acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809 located_in GO:0010008 endosome membrane Reactome:REACT_26016 PR:000036038 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human) acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809 enables GO:0004674 protein serine/threonine kinase activity Reactome:REACT_27000 located_in GO:0010008 endosome membrane Reactome:REACT_27000 PR:000036049 K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human) acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809 located_in GO:0010008 endosome membrane Reactome:REACT_25755 PR:000036004 LY96:TLR4 complex (human) acts_upstream_of_or_within GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894 located_in GO:0005886 plasma membrane Reactome:REACT_7105 PR:000036135 TIRAP:PIP2:activated TLR4 complex (human) acts_upstream_of_or_within GO:0002755 MyD88-dependent toll-like receptor signaling pathway Reactome:REACT_25222 located_in GO:0005886 plasma membrane Reactome:REACT_152404 PR:000036060 pro-caspase-8:fadd:rip1:ticam1:ticam2:activated TLR4 complex (human) acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809 enables GO:0004197 cysteine-type endopeptidase activity Reactome:REACT_151344 located_in GO:0010008 endosome membrane Reactome:REACT_151344 PR:000036058 rip1:rip3:ticam1:ticam2:activated TLR4 complex (human) acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809 located_in GO:0010008 endosome membrane Reactome:REACT_151344 PR:000036027 sarm:ticam1:ticam2:activated TLR4 complex (human) acts_upstream_of_or_within GO:0034128 negative regulation of MyD88-independent toll-like receptor signaling pathway Reactome:REACT_151758 located_in GO:0010008 endosome membrane Reactome:REACT_151758 PR:000036123 p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human) acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809 located_in GO:0010008 endosome membrane Reactome:REACT_26959 PR:000036036 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human) acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809 enables GO:0004674 protein serine/threonine kinase activity Reactome:REACT_27000 located_in GO:0010008 endosome membrane Reactome:REACT_27000 PR:000036024 rip1:ticam1:ticam2:activated TLR4 complex (human) acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809 located_in GO:0010008 endosome membrane Reactome:REACT_25948 PR:000036030 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human) acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809 enables GO:0004674 protein serine/threonine kinase activity Reactome:REACT_27000 located_in GO:0010008 endosome membrane Reactome:REACT_27000 PR:000036022 traf3:ticam1:ticam2:activated TLR4 complex (human) acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_124037 enables GO:0004842 ubiquitin-protein transferase activity Reactome:REACT_124037 located_in GO:0010008 endosome membrane Reactome:REACT_124037 PR:000035738 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human) acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809 located_in GO:0010008 endosome membrane Reactome:REACT_26039 PR:000027192 pIRAK4:MYD88:TIRAP:activated TLR4 complex (human) acts_upstream_of_or_within GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894 PR:000027183 IRAK4:MYD88:TIRAP:activated TLR4 complex (human) acts_upstream_of_or_within GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894 PR:000035734 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human) acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809 enables GO:0004674 protein serine/threonine kinase activity Reactome:REACT_26036 located_in GO:0010008 endosome membrane Reactome:REACT_26036 PR:000028680 traf6:ticam1:ticam2:activated TLR4 complex (human) acts_upstream_of_or_within GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6809 acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809 located_in GO:0010008 endosome membrane Reactome:REACT_25948 PR:000036056 rip3:ticam1:ticam2:activated TLR4 complex (human) acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809 located_in GO:0010008 endosome membrane Reactome:REACT_152149 Cellular Location GO Term Protein Forms & Complexes Evidence GO:0005886 plasma membrane PR:000025786 hLY96/iso:1/SigPep-/NGlyco:1 Asn-26/Asn-114, MOD:00160 Reactome:REACT_7660 PR:000036004 LY96:TLR4 complex (human) Reactome:REACT_7105 PR:000036135 TIRAP:PIP2:activated TLR4 complex (human) Reactome:REACT_152404 PR:000037447 TIRAP:PIP2:BTK:activated TLR4 complex (human) Reactome:REACT_120882 PR:000037448 pTIRAP:PIP2:BTK:activated TLR4 complex (human) Reactome:REACT_125282 GO:0010008 endosome membrane PR:000027208 ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_7861 PR:000028678 ticam2:activated TLR4 complex (human) Reactome:REACT_7083 PR:000028680 traf6:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_25948 PR:000035715 pUbtraf6:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_25867 PR:000035734 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_26036 PR:000035738 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_26039 PR:000036022 traf3:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_124037 PR:000036024 rip1:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_25948 PR:000036027 sarm:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_151758 PR:000036030 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_27000 PR:000036034 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_27000 PR:000036036 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_27000 PR:000036038 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_27000 PR:000036041 K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_124855 PR:000036049 K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_25755 PR:000036053 IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_26016 PR:000036056 rip3:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_152149 PR:000036058 rip1:rip3:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_151344 PR:000036060 pro-caspase-8:fadd:rip1:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_151344 PR:000036123 p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human) Reactome:REACT_26959 PR:000036124 p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human) Reactome:REACT_26959 GO:0005615 extracellular space PR:000025786 hLY96/iso:1/SigPep-/NGlyco:1 Asn-26/Asn-114, MOD:00160 PMID:19783674 PR:000025786 hLY96/iso:1/SigPep-/NGlyco:1 Asn-26/Asn-114, MOD:00160 PMID:11593030

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