[Term]
id: PR:000049434
name: TGF-beta receptor type-2, signal peptide removed neddylated 1 (human)
def: "A TGF-beta receptor type-2 (human) that has had the signal peptide removed and has been post-translationally modified to include neddylated lysine at positions 556 and 567 of the amino acid sequence represented by UniProtKB:P37173. UniProtKB:P37173, 23-567, Lys-556/Lys-567, MOD:01150." [PRO:DNx, Reactome:R-HSA-4332222]
comment: Category=organism-modification.
synonym: "hTGFBR2/SigPep-/Nedd:1" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000024426, Lys-556/Lys-567, MOD:01150" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P37173, 23-567, Lys-556/Lys-567, MOD:01150" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-4332222 "PR:000049434 located_in GO:0005886"
is_a: PR:P37173 ! TGF-beta receptor type-2 (human)
relationship: has_part MOD:01150 ! neddylated lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part SO:0000418 ! signal_peptide

[Term]
id: PR:000025962
name: TGF-beta receptor type-2 isoform RII-1, signal peptide removed phosphorylated 1 (human)
def: "A TGF-beta receptor type-2 isoform RII-1, signal peptide removed phosphorylated 1 in human. UniProtKB:P37173-1, 23-567, Ser-213/Ser-409, MOD:00046|Tyr-259/Tyr-336/Tyr-424, MOD:00048." [PID:TGFB/TGFBR2/TGFBR1]
comment: Category=organism-modification.
synonym: "hTGFBR2/iso:1/SigPep-/Phos:1" EXACT [PRO:DAN]
synonym: "hTGFBR2/iso:RII-1/SigPep-/Phos:1" EXACT PRO-short-label [PRO:DAN]
synonym: "TGF-beta receptor type-2 isoform 1, signal peptide removed phosphorylated 1 (human)" EXACT [PRO:DNx]
synonym: "UniProtKB:P37173-1, 23-567, Ser-213/Ser-409, MOD:00046|Tyr-259/Tyr-336/Tyr-424, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000003176 ! TGF-beta receptor type-2 isoform RII-1, signal peptide removed phosphorylated 1
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine

[Term]
id: PR:000000005
name: TGF-beta receptor type-2
def: "A protein that is a translation product of the human TGFBR2 gene or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=gene. The core domain organization is composed of a signal peptide followed by a Transforming growth factor beta receptor 2 ectodomain (Pfam:PF08917), a transmembrane domain and a C-terminal Protein kinase domain (Pfam:PF00069).
synonym: "TGFBR2" EXACT PRO-short-label [PRO:DNx]
synonym: "TGFR-2" EXACT []
synonym: "TbetaR-II" EXACT []
synonym: "TGF-beta receptor type II" EXACT []
synonym: "TGF-beta type II receptor" EXACT []
synonym: "transforming growth factor-beta receptor type II" EXACT []
xref: IUPHARobj:1795
xref: PIRSF:PIRSF037393
is_a: PR:000000001 ! protein

[Term]
id: PR:000000062
name: TGF-beta receptor type-2 sequence variant N435S (human)
def: "A TGF-beta receptor type-2 (human) that has a Ser residue at the position equivalent to Asn-435 of the amino acid sequence represented by UniProtKB:P37173-1. Example: UniProtKB:P37173-1, Asn-435, CHEBI:29999." [PMID:11212236, PRO:CNA, PRO:DAN]
comment: Category=organism-sequence.
synonym: "hTGFBR2/var:N435S" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P37173-1, Asn-435, CHEBI:29999" NARROW PRO-proteoform-std [PRO:DAN]
synonym: "TGF-beta receptor type-2 sequence variant 6 (human)" EXACT [PRO:DNx]
xref: UniProtKB_VAR:VAR_022356
is_a: PR:P37173 ! TGF-beta receptor type-2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000000063
name: TGF-beta receptor type-2 sequence variant V447A (human)
def: "A TGF-beta receptor type-2 (human) that has an Ala residue at the position equivalent to Val-447 of the amino acid sequence represented by UniProtKB:P37173-1. Example: UniProtKB:P37173-1, Val-447, CHEBI:46217." [PMID:11212236, PRO:CNA, PRO:DAN]
comment: Category=organism-sequence. Note: This form is involved in breast tumors.
synonym: "hTGFBR2/var:V447A" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P37173-1, Val-447, CHEBI:46217" NARROW PRO-proteoform-std [PRO:DAN]
synonym: "TGF-beta receptor type-2 sequence variant 7 (human)" EXACT [PRO:DNx]
xref: UniProtKB_VAR:VAR_022357
is_a: PR:P37173 ! TGF-beta receptor type-2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000000060
name: TGF-beta receptor type-2 sequence variant A355P (human)
def: "A TGF-beta receptor type-2 (human) that has a Pro residue at the position equivalent to Ala-355 of the amino acid sequence represented by UniProtKB:P37173-1. Example: UniProtKB:P37173-1, Ala-355, CHEBI:50342." [PMID:15731757, PRO:CNA, PRO:DAN]
comment: Category=organism-sequence.
synonym: "hTGFBR2/var:A355P" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P37173-1, Ala-355, CHEBI:50342" NARROW PRO-proteoform-std [PRO:DAN]
synonym: "TGF-beta receptor type-2 sequence variant 4 (human)" EXACT [PRO:DNx]
xref: UniProtKB_VAR:VAR_022353
is_a: PR:P37173 ! TGF-beta receptor type-2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000000061
name: TGF-beta receptor type-2 sequence variant V387M (human)
def: "A TGF-beta receptor type-2 (human) that has a Met residue at the position equivalent to Val-387 of the amino acid sequence represented by UniProtKB:P37173-1. Example: UniProtKB:P37173-1, Val-387, CHEBI:16044." [PMID:11212236, PRO:CNA, PRO:DAN]
comment: Category=organism-sequence.
synonym: "hTGFBR2/var:V387M" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P37173-1, Val-387, CHEBI:16044" NARROW PRO-proteoform-std [PRO:DAN]
synonym: "TGF-beta receptor type-2 sequence variant 5 (human)" EXACT [PRO:DNx]
xref: UniProtKB_VAR:VAR_022355
is_a: PR:P37173 ! TGF-beta receptor type-2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000000064
name: TGF-beta receptor type-2 sequence variant S449F (human)
def: "A TGF-beta receptor type-2 (human) that has a Phe residue at the position equivalent to Ser-449 of the amino acid sequence represented by UniProtKB:P37173-1. Example: UniProtKB:P37173-1, Ser-449, CHEBI:29997." [PMID:15235604, PRO:CNA, PRO:DAN]
comment: Category=organism-sequence.
synonym: "hTGFBR2/var:S449F" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P37173-1, Ser-449, CHEBI:29997" NARROW PRO-proteoform-std [PRO:DAN]
synonym: "TGF-beta receptor type-2 sequence variant 8 (human)" EXACT [PRO:DNx]
xref: UniProtKB_VAR:VAR_022358
is_a: PR:P37173 ! TGF-beta receptor type-2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000000065
name: TGF-beta receptor type-2 sequence variant L452M (human)
def: "A TGF-beta receptor type-2 (human) that has a Met residue at the position equivalent to Leu-452 of the amino acid sequence represented by UniProtKB:P37173-1. Example: UniProtKB:P37173-1, Leu-452, CHEBI:16044." [PMID:11212236, PRO:CNA, PRO:DAN]
comment: Category=organism-sequence.
synonym: "hTGFBR2/var:L452M" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P37173-1, Leu-452, CHEBI:16044" NARROW PRO-proteoform-std [PRO:DAN]
synonym: "TGF-beta receptor type-2 sequence variant 9 (human)" EXACT [PRO:DNx]
xref: UniProtKB_VAR:VAR_022359
is_a: PR:P37173 ! TGF-beta receptor type-2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P37173
name: TGF-beta receptor type-2 (human)
def: "A TGF-beta receptor type-2 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P37173]
comment: Category=organism-gene.
synonym: "TGFBR2" RELATED Gene-based [UniProtKB:P37173]
synonym: "hTGFBR2" EXACT PRO-short-label [PRO:DNx]
synonym: "TGFR-2 (human)" EXACT [UniProtKB:P37173]
synonym: "TbetaR-II (human)" EXACT [UniProtKB:P37173]
synonym: "TGF-beta receptor type II (human)" EXACT [UniProtKB:P37173]
synonym: "TGF-beta type II receptor (human)" EXACT [UniProtKB:P37173]
synonym: "transforming growth factor-beta receptor type II (human)" EXACT [UniProtKB:P37173]
xref: DTO:03100524
xref: UniProtKB:P37173
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000005 ! TGF-beta receptor type-2
relationship: has_gene_template HGNC:11773 ! TGFBR2 (human)

[Term]
id: PR:P37173-2
name: TGF-beta receptor type-2 isoform RII-2 (human)
def: "A TGF-beta receptor type-2 isoform RII-2 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P37173]
comment: Category=organism-sequence.
synonym: "hTGFBR2/iso:RII-2" EXACT PRO-short-label [PRO:DNx]
synonym: "TGFBR2 isoform 2 (human)" EXACT [PRO:DNx]
synonym: "TGF-beta receptor type-2 isoform 2 (human)" EXACT [PRO:DNx]
xref: UniProtKB:P37173-2
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000049 ! TGF-beta receptor type-2 isoform RII-2

[Term]
id: PR:000036408
name: TGF-beta receptor type-2 isoform RII-1, signal peptide removed form (human)
def: "A TGF-beta receptor type-2 isoform RII-1, signal peptide removed form in human. UniProtKB:P37173-1, 23-567." [PMID:11483955, PMID:11850637, PMID:1310899, PMID:1850637, PMID:8774881, PRO:CNA]
comment: Category=organism-modification.
synonym: "PRO_0000024426" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hTGFBR2/iso:1/SigPep-" EXACT [PRO:DNx]
synonym: "hTGFBR2/iso:RII-1/SigPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P37173-1, 23-567" EXACT PRO-proteoform-std [PRO:DNx]
synonym: "TGF-beta receptor type-2 isoform 1, signal peptide removed form (human)" EXACT [PRO:DNx]
xref: Reactome:R-HSA-170842 "PR:000036408 located_in GO:0005886"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000409 ! TGF-beta receptor type-2 isoform RII-1, signal peptide removed form

[Term]
id: PR:000000057
name: TGF-beta receptor type-2 sequence variant G357W (human)
def: "A TGF-beta receptor type-2 (human) that has a Trp residue at the position equivalent to Gly-357 of the amino acid sequence represented by UniProtKB:P37173-1. Example: UniProtKB:P37173-1, Gly-357, CHEBI:29954." [PMID:15731757, PRO:CNA, PRO:DAN]
comment: Category=organism-sequence.
synonym: "hTGFBR2/var:G357W" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P37173-1, Gly-357, CHEBI:29954" NARROW PRO-proteoform-std [PRO:DAN]
synonym: "TGF-beta receptor type-2 sequence variant 16 (human)" EXACT [PRO:DNx]
xref: UniProtKB_VAR:VAR_022354
is_a: PR:P37173 ! TGF-beta receptor type-2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000000056
name: TGF-beta receptor type-2 sequence variant R537C (human)
def: "A TGF-beta receptor type-2 (human) that has a Cys residue at the position equivalent to Arg-537 of the amino acid sequence represented by UniProtKB:P37173-1. Example: UniProtKB:P37173-1, Arg-537, CHEBI:29950." [PMID:15235604, PRO:CNA, PRO:DAN]
comment: Category=organism-sequence.
synonym: "hTGFBR2/var:R537C" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P37173-1, Arg-537, CHEBI:29950" NARROW PRO-proteoform-std [PRO:DAN]
synonym: "TGF-beta receptor type-2 sequence variant 15 (human)" EXACT [PRO:DNx]
xref: UniProtKB_VAR:VAR_022362
is_a: PR:P37173 ! TGF-beta receptor type-2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000000055
name: TGF-beta receptor type-2 sequence variant R528H (human)
def: "A TGF-beta receptor type-2 (human) that has a His residue at the position equivalent to Arg-528 of the amino acid sequence represented by UniProtKB:P37173-1. Example: UniProtKB:P37173-1, Arg-528, CHEBI:29979." [PMID:15731757, PRO:CNA, PRO:DAN]
comment: Category=organism-sequence.
synonym: "hTGFBR2/var:R528H" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P37173-1, Arg-528, CHEBI:29979" NARROW PRO-proteoform-std [PRO:DAN]
synonym: "TGF-beta receptor type-2 sequence variant 14 (human)" EXACT [PRO:DNx]
xref: UniProtKB_VAR:VAR_022361
is_a: PR:P37173 ! TGF-beta receptor type-2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000000054
name: TGF-beta receptor type-2 sequence variant R528C (human)
def: "A TGF-beta receptor type-2 (human) that has a Cys residue at the position equivalent to Arg-528 of the amino acid sequence represented by UniProtKB:P37173-1. Example: UniProtKB:P37173-1, Arg-528, CHEBI:29950." [PMID:15731757, PRO:CNA, PRO:DAN]
comment: Category=organism-sequence.
synonym: "hTGFBR2/var:R528C" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P37173-1, Arg-528, CHEBI:29950" NARROW PRO-proteoform-std [PRO:DAN]
synonym: "TGF-beta receptor type-2 sequence variant 13 (human)" EXACT [PRO:DNx]
xref: UniProtKB_VAR:VAR_022360
is_a: PR:P37173 ! TGF-beta receptor type-2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000000053
name: TGF-beta receptor type-2 sequence variant E526Q (human)
def: "A TGF-beta receptor type-2 (human) that has a Gln residue at the position equivalent to Glu-526 of the amino acid sequence represented by UniProtKB:P37173-1. Example: UniProtKB:P37173-1, Glu-526, CHEBI:30011." [PMID:10789724, PRO:CNA, PRO:DAN]
comment: Category=organism-sequence.
synonym: "hTGFBR2/var:E526Q" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P37173-1, Glu-526, CHEBI:30011" NARROW PRO-proteoform-std [PRO:DAN]
synonym: "TGF-beta receptor type-2 sequence variant 12 (human)" EXACT [PRO:DNx]
xref: UniProtKB_VAR:VAR_015816
is_a: PR:P37173 ! TGF-beta receptor type-2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000000052
name: TGF-beta receptor type-2 sequence variant R460C (human)
def: "A TGF-beta receptor type-2 (human) that has a Cys residue at the position equivalent to Arg-460 of the amino acid sequence represented by UniProtKB:P37173-1. Example: UniProtKB:P37173-1, Arg-460, CHEBI:29950." [PMID:15731757, PRO:CNA, PRO:DAN]
comment: Category=organism-sequence.
synonym: "hTGFBR2/var:R460C" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P37173-1, Arg-460, CHEBI:29950" NARROW PRO-proteoform-std [PRO:DAN]
synonym: "TGF-beta receptor type-2 sequence variant 11 (human)" EXACT [PRO:DNx]
xref: UniProtKB_VAR:VAR_029760
is_a: PR:P37173 ! TGF-beta receptor type-2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000000051
name: TGF-beta receptor type-2 sequence variant R460H (human)
def: "A TGF-beta receptor type-2 (human) that has a His residue at the position equivalent to Arg-460 of the amino acid sequence represented by UniProtKB:P37173-1. Example: UniProtKB:P37173-1, Arg-460, CHEBI:29979." [PMID:15731757, PRO:CNA, PRO:DAN]
comment: Category=organism-sequence.
synonym: "hTGFBR2/var:R460H" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P37173-1, Arg-460, CHEBI:29979" NARROW PRO-proteoform-std [PRO:DAN]
synonym: "TGF-beta receptor type-2 sequence variant 10 (human)" EXACT [PRO:DNx]
xref: UniProtKB_VAR:VAR_029761
is_a: PR:P37173 ! TGF-beta receptor type-2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000000050
name: TGF-beta receptor type-2 sequence variant L308P (human)
def: "A TGF-beta receptor type-2 (human) that has a Pro residue at the position equivalent to Leu-308 of the amino acid sequence represented by UniProtKB:P37173-1. Example: UniProtKB:P37173-1, Leu-308, CHEBI:50342." [PMID:15235604, PRO:CNA, PRO:DAN]
comment: Category=organism-sequence.
synonym: "hTGFBR2/var:L308P" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P37173-1, Leu-308, CHEBI:50342" NARROW PRO-proteoform-std [PRO:DAN]
synonym: "TGF-beta receptor type-2 sequence variant 1 (human)" EXACT [PRO:DNx]
xref: UniProtKB_VAR:VAR_022351
is_a: PR:P37173 ! TGF-beta receptor type-2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P37173-1
name: TGF-beta receptor type-2 isoform RII-1 (human)
def: "A TGF-beta receptor type-2 isoform RII-1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P37173]
comment: Category=organism-sequence. Requested by=PubChem.
synonym: "hTGFBR2/iso:RII-1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P37173-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000048 ! TGF-beta receptor type-2 isoform RII-1

[Term]
id: PR:000000059
name: TGF-beta receptor type-2 sequence variant Y336N (human)
def: "A TGF-beta receptor type-2 (human) that has an Asn residue at the position equivalent to Tyr-336 of the amino acid sequence represented by UniProtKB:P37173-1. Example: UniProtKB:P37173-1, Tyr-336, CHEBI:50347." [PMID:15731757, PRO:CNA, PRO:DAN]
comment: Category=organism-sequence.
synonym: "hTGFBR2/var:Y336N" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P37173-1, Tyr-336, CHEBI:50347" NARROW PRO-proteoform-std [PRO:DAN]
synonym: "TGF-beta receptor type-2 sequence variant 3 (human)" EXACT [PRO:DNx]
xref: UniProtKB_VAR:VAR_022352
is_a: PR:P37173 ! TGF-beta receptor type-2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000000058
name: TGF-beta receptor type-2 sequence variant T315M (human)
def: "A TGF-beta receptor type-2 (human) that has a Met residue at the position equivalent to Thr-315 of the amino acid sequence represented by UniProtKB:P37173-1. Example: UniProtKB:P37173-1, Thr-315, CHEBI:16044." [PMID:9590282, PRO:CNA, PRO:DAN]
comment: Category=organism-sequence.
synonym: "hTGFBR2/var:T315M" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P37173-1, Thr-315, CHEBI:16044" NARROW PRO-proteoform-std [PRO:DAN]
synonym: "TGF-beta receptor type-2 sequence variant 2 (human)" EXACT [PRO:DNx]
xref: UniProtKB_VAR:VAR_008156
is_a: PR:P37173 ! TGF-beta receptor type-2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens