[Term] id: PR:000000016 name: HECT domain-containing E3 ubiquitin-protein ligase with WW domains def: "A protein that has a core domain composition consisting of the C-terminal HECT-domain (ubiquitin-transferase) (Pfam:PF00632), which is catalytically involved in the attachment of ubiquitin to substrate proteins, and an N-terminal extension with a C2 domain (Pfam:PF00168) and two to three copies of the WW domain (Pfam:PF00397) that mediate the substrate specificity." [PMID:18047743] comment: Category=family. xref: PIRSF:PIRSF001569 is_a: PR:000000001 ! protein