[Term] id: PR:000000100 name: interferon gamma isoform 1 def: "An interferon gamma that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P01579-1 or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=sequence. synonym: "IFNG/iso:1" EXACT PRO-short-label [PRO:DNx] is_a: PR:000000017 ! interferon gamma [Term] id: PR:P01579-1 name: interferon gamma isoform 1 (human) def: "An interferon gamma isoform 1 that is encoded in the genome of human." [PRO:CNA] comment: Category=organism-sequence. synonym: "hIFNG/iso:1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P01579-1 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000000100 ! interferon gamma isoform 1 [Term] id: PR:000000445 name: interferon gamma isoform 1, signal peptide removed form def: "An interferon gamma isoform 1 that has had the signal peptide removed to yield the mature protein." [PRO:CNA] comment: Category=modification. synonym: "IFNG/iso:1/SigPep-" EXACT PRO-short-label [PRO:DNx] synonym: "interferon gamma isoform 1 cleaved 1" EXACT [] intersection_of: PR:000000100 ! interferon gamma isoform 1 intersection_of: lacks_part SO:0000418 ! signal_peptide [Term] id: PR:000000446 name: interferon gamma isoform 1, signal peptide removed glycosylated form def: "An interferon gamma isoform 1, signal peptide removed form that includes at least one glycosylated residue." [PMID:3109913, PRO:CNA] comment: Category=modification. synonym: "IFNG/iso:1/SigPep-/GlycoRes+" EXACT PRO-short-label [PRO:DNx] synonym: "interferon gamma isoform 1 cleaved and glycosylated 1" EXACT [] intersection_of: has_part MOD:00693 ! glycosylated residue intersection_of: PR:000000445 ! interferon gamma isoform 1, signal peptide removed form [Term] id: PR:000000447 name: interferon gamma isoform 1 cleaved and N-glycosylated 2 def: "An interferon gamma isoform 1, signal peptide removed glycosylated form that is a mature protein with N-linked glycosylation and partial proteolytic degradation of the C-terminus. Example: UniProtKB:P01579-1, 24-161, Asn-48/Asn-120, MOD:00160." [PRO:CNA, PRO:DAN] comment: Category=modification. synonym: "IFNG/iso:1/ClvNGlyco:2" EXACT PRO-short-label [PRO:DNx] is_a: PR:000000446 ! interferon gamma isoform 1, signal peptide removed glycosylated form relationship: has_part MOD:00160 ! N4-glycosyl-L-asparagine [Term] id: PR:000018270 name: interferon gamma, signal peptide removed form def: "An interferon gamma that has had the signal peptide removed." [PRO:DNx] comment: Category=modification. synonym: "IFNG/SigPep-" EXACT PRO-short-label [PRO:DNx] intersection_of: PR:000000017 ! interferon gamma intersection_of: lacks_part SO:0000418 ! signal_peptide [Term] id: PR:000018271 name: interferon gamma proteolytic cleavage product def: "An interferon gamma that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "IFNG/ClvPrd" EXACT PRO-short-label [PRO:DNx] intersection_of: output_of GO:0016485 ! protein processing intersection_of: PR:000000017 ! interferon gamma [Term] id: PR:000000017 name: interferon gamma def: "A type II interferon that is a translation product of the human IFNG gene or a 1:1 ortholog thereof. The core domain structure consists of an Interferon gamma domain (Pfam:PF00714) that is four-helical cytokine domain with an additional helix in one of the crossover connections. It is a cytokine produced by lymphocytes activated by specific antigens or mitogens that has important immunoregulatory functions." [PRO:CNA] comment: Category=gene. synonym: "IFNG" EXACT PRO-short-label [PRO:DNx] synonym: "IFN-gamma" EXACT [] synonym: "immune interferon" EXACT [] xref: PIRSF:PIRSF001936 is_a: PR:000024990 ! type II interferon [Term] id: PR:000036407 name: interferon gamma isoform 1, signal peptide removed glycosylated form (mouse) def: "An interferon gamma isoform 1, signal peptide removed glycosylated form in mouse. UniProtKB:P01580-1, 23-155, MOD:00693." [PMID:11027433, PMID:11057672, PMID:11728336, PMID:12882831, PMID:12925700, PMID:15240714, PMID:15240719, PRO:CNA] comment: Category=organism-modification. synonym: "PRO_0000016453, MOD:00693" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "mIFNG/iso:1/SigPep-/GlycoRes+" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P01580-1, 23-155, MOD:00693" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000000446 ! interferon gamma isoform 1, signal peptide removed glycosylated form relationship: has_part MOD:00693 ! glycosylated residue [Term] id: PR:000036420 name: interferon gamma isoform 1 cleaved and N-glycosylated 2 (human) def: "An interferon gamma isoform 1 cleaved and N-glycosylated 2 in human. UniProtKB:P01579-1, 24-161, Asn-48/Asn-120, MOD:00160." [PMID:1902591, PMID:6427223, PRO:CNA] comment: Category=organism-modification. synonym: "hIFNG/iso:1/ClvNGlyco:2" EXACT PRO-short-label [PRO:DNx] synonym: "PRO_0000016444, Asn-48/Asn-120, MOD:00160" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "UniProtKB:P01579-1, 24-161, Asn-48/Asn-120, MOD:00160" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000000447 ! interferon gamma isoform 1 cleaved and N-glycosylated 2 relationship: has_part MOD:00160 ! N4-glycosyl-L-asparagine [Term] id: PR:P01580-1 name: interferon gamma isoform 1 (mouse) def: "An interferon gamma isoform 1 that is encoded in the genome of mouse." [PRO:CNA] comment: Category=organism-sequence. synonym: "mIFNG/iso:1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P01580-1 intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000000100 ! interferon gamma isoform 1 [Term] id: PR:000036419 name: interferon gamma isoform 1, signal peptide removed N-glycosylated 1 (human) def: "An interferon gamma isoform 1, signal peptide removed glycosylated form in human in which N-linked glycosylation occurs at Asn-48 and Asn-120. UniProtKB:P01579-1, 24-157, Asn-48/Asn-120, MOD:00160." [PMID:10986460, PMID:3109913, PMID:6427223, PRO:CNA, PRO:DAN] comment: Category=organism-modification. synonym: "hIFNG/iso:1/SigPep-/NGlyco:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P01579-1, 24-157, Asn-48/Asn-120, MOD:00160" EXACT PRO-proteoform-std [PRO:DNx] is_a: PR:000000446 ! interferon gamma isoform 1, signal peptide removed glycosylated form relationship: has_part MOD:00160 ! N4-glycosyl-L-asparagine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000036418 name: interferon gamma isoform 1, signal peptide removed form (mouse) def: "An interferon gamma isoform 1, signal peptide removed form in mouse. UniProtKB:P01580-1, 23-155." [PMID:11441112, PRO:CNA] comment: Category=organism-modification. synonym: "PRO_0000016453" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "mIFNG/iso:1/SigPep-" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P01580-1, 23-155" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000000445 ! interferon gamma isoform 1, signal peptide removed form [Term] id: PR:P01581 name: interferon gamma (rat) def: "An interferon gamma that is encoded in the genome of rat." [OMA:P01581, PANTHER:PTHR11419:SF0, PRO:DNx] comment: Category=organism-gene. synonym: "Ifng" RELATED Gene-based [UniProtKB:P01581] synonym: "rIFNG" EXACT PRO-short-label [PRO:DNx] synonym: "IFN-gamma (rat)" EXACT [UniProtKB:P01581] xref: UniProtKB:P01581 intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus intersection_of: PR:000000017 ! interferon gamma relationship: has_gene_template RGD:2866 ! Ifng (rat) [Term] id: PR:P01579 name: interferon gamma (human) def: "An interferon gamma that is encoded in the genome of human." [PRO:CNA, UniProtKB:P01579] comment: Category=organism-gene. synonym: "IFNG" RELATED Gene-based [UniProtKB:P01579] synonym: "hIFNG" EXACT PRO-short-label [PRO:DNx] synonym: "IFN-gamma (human)" EXACT [UniProtKB:P01579] synonym: "immune interferon (human)" EXACT [UniProtKB:P01579] xref: UniProtKB:P01579 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000000017 ! interferon gamma relationship: has_gene_template HGNC:5438 ! IFNG (human) [Term] id: PR:P01580 name: interferon gamma (mouse) def: "An interferon gamma that is encoded in the genome of mouse." [OMA:P01580, PRO:DNx] comment: Category=organism-gene. synonym: "Ifng" RELATED Gene-based [UniProtKB:P01580] synonym: "mIFNG" EXACT PRO-short-label [PRO:DNx] synonym: "IFN-gamma (mouse)" EXACT [UniProtKB:P01580] xref: UniProtKB:P01580 intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000000017 ! interferon gamma relationship: has_gene_template MGI:107656 ! Ifng (mouse) [Term] id: PR:P49708 name: interferon gamma (chicken) def: "An interferon gamma that is encoded in the genome of chicken." [OMA:P49708, PANTHER:PTHR11419:SF0, PRO:DNx] comment: Category=organism-gene. synonym: "IFNG" RELATED Gene-based [UniProtKB:P49708] synonym: "chick-IFNG" EXACT PRO-short-label [PRO:DNx] synonym: "IFN-gamma (chicken)" EXACT [UniProtKB:P49708] xref: UniProtKB:P49708 intersection_of: only_in_taxon NCBITaxon:9031 ! Gallus gallus intersection_of: PR:000000017 ! interferon gamma relationship: has_gene_template NCBIGene:396054 ! IFNG (chicken)