[Term]
id: PR:P36896
name: activin receptor type-1B (human)
def: "An activin receptor type-1B that is encoded in the genome of human." [PRO:CNA, UniProtKB:P36896]
comment: Category=organism-gene.
synonym: "ALK4" RELATED Gene-based [UniProtKB:P36896]
synonym: "ACVR1B" RELATED Gene-based [UniProtKB:P36896]
synonym: "ACVRLK4" RELATED Gene-based [UniProtKB:P36896]
synonym: "hACVR1B" EXACT PRO-short-label [PRO:DNx]
synonym: "SKR2 (human)" EXACT [UniProtKB:P36896]
synonym: "ALK-4 (human)" EXACT [UniProtKB:P36896]
synonym: "ACTR-IB (human)" EXACT [UniProtKB:P36896]
synonym: "activin receptor type IB (human)" EXACT [UniProtKB:P36896]
synonym: "activin receptor-like kinase 4 (human)" EXACT [UniProtKB:P36896]
synonym: "serine/threonine-protein kinase receptor R2 (human)" EXACT [UniProtKB:P36896]
xref: DTO:03100009
xref: UniProtKB:P36896
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000068 ! activin receptor type-1B
relationship: has_gene_template HGNC:172 ! ACVR1B (human)

[Term]
id: PR:P36896-4
name: activin receptor type-1B isoform h4 (human)
def: "An activin receptor type-1B (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P36896-4." [PRO:DNx, UniProtKB:P36896]
comment: Category=organism-sequence.
synonym: "hACVR1B/iso:h4" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P36896-4
is_a: PR:P36896 ! activin receptor type-1B (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000046257
name: activin receptor type-1B, signal peptide removed phosphorylated 3 (human)
def: "An activin receptor type-1B (human) that has had the signal peptide removed and has been post-translationally modified to include phosphoserine at positions 187, 189, 191 and 193, and phosphothreonine at positions 188 and 206 of the amino acid sequence represented by UniProtKB:P36896. UniProtKB:P36896, 24-505, Ser-187/Ser-189/Ser-191/Ser-193, MOD:00046|Thr-188/Thr-206, MOD:00047." [PRO:DNx, Reactome:R-HSA-205780]
comment: Category=organism-modification.
synonym: "hACVR1B/SigPep-/Phos:3" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000024417, Ser-187/Ser-189/Ser-191/Ser-193, MOD:00046|Thr-188/Thr-206, MOD:00047" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P36896, 24-505, Ser-187/Ser-189/Ser-191/Ser-193, MOD:00046|Thr-188/Thr-206, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-205780 "PR:000046257 located_in GO:0005886"
is_a: PR:P36896 ! activin receptor type-1B (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part SO:0000418 ! signal_peptide

[Term]
id: PR:000046256
name: activin receptor type-1B, signal peptide removed form (human)
def: "An activin receptor type-1B (human) that has had the signal peptide removed. UniProtKB:P36896, 24-505." [PRO:DNx, Reactome:R-HSA-205867]
comment: Category=organism-modification.
synonym: "PRO_0000024417" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hACVR1B/SigPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P36896, 24-505" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-205867 "PR:000046256 located_in GO:0005886"
intersection_of: PR:P36896 ! activin receptor type-1B (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000036437
name: activin receptor type-1B isoform 1 phosphorylated 1 (human)
def: "An activin receptor type-1B isoform 1 phosphorylated 1 in human." [PMID:12065756, PMID:12665502, PMID:8397373, PMID:8622651, PRO:CNA]
comment: Category=organism-modification.
synonym: "hACVR1B/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000525 ! activin receptor type-1B isoform 1 phosphorylated 1
relationship: has_part MOD:00696 ! phosphorylated residue

[Term]
id: PR:000036438
name: activin receptor type-1B isoform 1 phosphorylated 2 (human)
def: "An activin receptor type-1B isoform 1 phosphorylated 2 in human. UniProtKB:P36896-1, Tyr-380, MOD:00048." [PMID:12112843, PRO:CNA]
comment: Category=organism-modification.
synonym: "hACVR1B/iso:1/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P36896-1, Tyr-380, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000526 ! activin receptor type-1B isoform 1 phosphorylated 2
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine

[Term]
id: PR:P36896-5
name: activin receptor type-1B isoform h5 (human)
def: "An activin receptor type-1B (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P36896-5." [PRO:DNx, UniProtKB:P36896]
comment: Category=organism-sequence.
synonym: "hACVR1B/iso:h5" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P36896-5
is_a: PR:P36896 ! activin receptor type-1B (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000000068
name: activin receptor type-1B
def: "A TGF-beta superfamily receptor type-1 that is a translation product of the human ACVR1B gene or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=gene.
synonym: "ALK4" RELATED Gene-based []
synonym: "SKR2" EXACT []
synonym: "ALK-4" EXACT []
synonym: "ACVR1B" EXACT PRO-short-label [PRO:DNx]
synonym: "ACTR-IB" EXACT []
synonym: "ACVRLK4" RELATED Gene-based []
synonym: "activin receptor type IB" EXACT []
synonym: "activin receptor-like kinase 4" EXACT []
synonym: "serine/threonine-protein kinase receptor R2" EXACT []
xref: IUPHARobj:1787
is_a: PR:000000006 ! TGF-beta superfamily receptor type-1

[Term]
id: PR:P36896-1
name: activin receptor type-1B isoform 1 (human)
def: "An activin receptor type-1B isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hACVR1B/iso:1" EXACT PRO-short-label [PRO:DNx]
synonym: "activin receptor type-1B isoform SKR2-1 (human)" EXACT [UniProtKB:P36896]
xref: UniProtKB:P36896-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000201 ! activin receptor type-1B isoform 1

[Term]
id: PR:P36896-2
name: activin receptor type-1B isoform 2 (human)
def: "An activin receptor type-1B isoform 2 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hACVR1B/iso:2" EXACT PRO-short-label [PRO:DNx]
synonym: "activin receptor type-1B isoform SKR2-2 (human)" EXACT [UniProtKB:P36896]
xref: UniProtKB:P36896-2
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000202 ! activin receptor type-1B isoform 2

[Term]
id: PR:P36896-3
name: activin receptor type-1B isoform 3 (human)
def: "An activin receptor type-1B isoform 3 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hACVR1B/iso:3" EXACT PRO-short-label [PRO:DNx]
synonym: "activin receptor type-1B isoform SKR2-3 (human)" EXACT [UniProtKB:P36896]
xref: UniProtKB:P36896-3
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000203 ! activin receptor type-1B isoform 3