[Term] id: PR:000000453 name: mitogen-activated protein kinase 1 isoform 1, initiator methionine removed acetylated form def: "A mitogen-activated protein kinase 1 isoform 1, initiator methionine removed form that includes at least one acetylated residue." [PMID:12665801, PRO:CNA] comment: Category=modification. synonym: "MAPK1/iso:1/InitMet-/AcRes+" EXACT PRO-short-label [PRO:DNx] synonym: "mitogen-activated protein kinase 1 isoform 1 cleaved and acetylated form" EXACT [] intersection_of: has_part MOD:00394 ! acetylated residue intersection_of: PR:000025465 ! mitogen-activated protein kinase 1 isoform 1, initiator methionine removed form [Term] id: PR:000000454 name: mitogen-activated protein kinase 1 isoform 1 phosphorylated form def: "A mitogen-activated protein kinase 1 isoform 1 that includes at least one phosphorylated residue." [PRO:CNA] comment: Category=modification. synonym: "MAPK1/iso:1/PhosRes+" EXACT PRO-short-label [PRO:DNx] intersection_of: has_part MOD:00696 ! phosphorylated residue intersection_of: PR:000000289 ! mitogen-activated protein kinase 1 isoform 1 [Term] id: PR:P63086 name: mitogen-activated protein kinase 1 (rat) def: "A mitogen-activated protein kinase 1 that is encoded in the genome of rat." [OMA:P63086, PANTHER:PTHR24055:SF70, PRO:DNx] comment: Category=organism-gene. synonym: "Erk2" RELATED Gene-based [UniProtKB:P63086] synonym: "Mapk" RELATED Gene-based [UniProtKB:P63086] synonym: "Mapk1" RELATED Gene-based [UniProtKB:P63086] synonym: "Prkm1" RELATED Gene-based [UniProtKB:P63086] synonym: "rMAPK1" EXACT PRO-short-label [PRO:DNx] synonym: "ERT1 (rat)" EXACT [UniProtKB:P63086] synonym: "ERK-2 (rat)" EXACT [UniProtKB:P63086] synonym: "MAPK 1 (rat)" EXACT [UniProtKB:P63086] synonym: "MAPK 2 (rat)" EXACT [UniProtKB:P63086] synonym: "p42-MAPK (rat)" EXACT [UniProtKB:P63086] synonym: "MAP kinase 1 (rat)" EXACT [UniProtKB:P63086] synonym: "MAP kinase 2 (rat)" EXACT [UniProtKB:P63086] synonym: "MAP kinase isoform p42 (rat)" EXACT [UniProtKB:P63086] synonym: "mitogen-activated protein kinase 2 (rat)" EXACT [UniProtKB:P63086] synonym: "extracellular signal-regulated kinase 2 (rat)" EXACT [UniProtKB:P63086] xref: UniProtKB:P63086 intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus intersection_of: PR:000000103 ! mitogen-activated protein kinase 1 relationship: has_gene_template RGD:70500 ! Mapk1 (rat) [Term] id: PR:P63085 name: mitogen-activated protein kinase 1 (mouse) def: "A mitogen-activated protein kinase 1 that is encoded in the genome of mouse." [OMA:P63085, PRO:DNx] comment: Category=organism-gene. synonym: "Erk2" RELATED Gene-based [UniProtKB:P63085] synonym: "Mapk" RELATED Gene-based [UniProtKB:P63085] synonym: "Mapk1" RELATED Gene-based [UniProtKB:P63085] synonym: "Prkm1" RELATED Gene-based [UniProtKB:P63085] synonym: "mMAPK1" EXACT PRO-short-label [PRO:DNx] synonym: "ERT1 (mouse)" EXACT [UniProtKB:P63085] synonym: "ERK-2 (mouse)" EXACT [UniProtKB:P63085] synonym: "MAPK 1 (mouse)" EXACT [UniProtKB:P63085] synonym: "MAPK 2 (mouse)" EXACT [UniProtKB:P63085] synonym: "p42-MAPK (mouse)" EXACT [UniProtKB:P63085] synonym: "MAP kinase 1 (mouse)" EXACT [UniProtKB:P63085] synonym: "MAP kinase 2 (mouse)" EXACT [UniProtKB:P63085] synonym: "MAP kinase isoform p42 (mouse)" EXACT [UniProtKB:P63085] synonym: "mitogen-activated protein kinase 2 (mouse)" EXACT [UniProtKB:P63085] synonym: "extracellular signal-regulated kinase 2 (mouse)" EXACT [UniProtKB:P63085] xref: UniProtKB:P63085 intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000000103 ! mitogen-activated protein kinase 1 relationship: has_gene_template MGI:1346858 ! Mapk1 (mouse) [Term] id: PR:000000103 name: mitogen-activated protein kinase 1 def: "A mitogen-activated protein kinase that is a translation product of the human MAPK1 gene or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=gene. synonym: "ERK2" RELATED Gene-based [] synonym: "ERT1" EXACT [] synonym: "Mapk" RELATED Gene-based [] synonym: "ERK-2" EXACT [] synonym: "MAPK1" EXACT PRO-short-label [PRO:DNx] synonym: "PRKM1" RELATED Gene-based [] synonym: "PRKM2" RELATED Gene-based [] synonym: "MAPK 1" EXACT [] synonym: "MAPK 2" EXACT [] synonym: "p42-MAPK" EXACT [] synonym: "MAP kinase 1" EXACT [] synonym: "MAP kinase 2" EXACT [] synonym: "MAP kinase isoform p42" EXACT [] synonym: "mitogen-activated protein kinase 2" EXACT [] synonym: "extracellular signal-regulated kinase 2" EXACT [] xref: IUPHARobj:1495 is_a: PR:000000019 ! mitogen-activated protein kinase [Term] id: PR:P63085-1 name: mitogen-activated protein kinase 1 isoform 1 (mouse) def: "A mitogen-activated protein kinase 1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA] comment: Category=organism-sequence. synonym: "mMAPK1/iso:1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P63085-1 intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000000289 ! mitogen-activated protein kinase 1 isoform 1 [Term] id: PR:P39745 name: mitogen-activated protein kinase mpk-1 (worm) def: "A mitogen-activated protein kinase 1 that is encoded in the genome of worm." [OMA:P39745, PANTHER:PTHR24055:SF70, PRO:DNx] comment: Category=organism-gene. synonym: "mpk-1" RELATED Gene-based [UniProtKB:P39745] synonym: "sur-1" RELATED Gene-based [UniProtKB:P39745] synonym: "F43C1.2" RELATED Gene-based [UniProtKB:P39745] synonym: "MAPK1 (worm)" EXACT PRO-short-label [PRO:DNx] synonym: "MAP kinase sur-1 (worm)" EXACT [UniProtKB:P39745] xref: UniProtKB:P39745 intersection_of: only_in_taxon NCBITaxon:6239 ! Caenorhabditis elegans intersection_of: PR:000000103 ! mitogen-activated protein kinase 1 relationship: has_gene_template WormBase:WBGene00003401 ! mpk-1 (worm) [Term] id: PR:P42525 name: extracellular signal-regulated kinase 1 (Dictyostelium discoideum) def: "A mitogen-activated protein kinase 1 that is encoded in the genome of Dictyostelium discoideum." [PRO:CNA] comment: Category=organism-gene. synonym: "erk1" RELATED Gene-based [UniProtKB:P42525] synonym: "erkA" RELATED Gene-based [UniProtKB:P42525] synonym: "Dicty-MAPK1" EXACT PRO-short-label [PRO:DNx] synonym: "DDB_G0286353" RELATED Gene-based [UniProtKB:P42525] synonym: "ERK1 (Dictyostelium discoideum)" EXACT [UniProtKB:P42525] synonym: "MAP kinase 1 (Dictyostelium discoideum)" EXACT [UniProtKB:P42525] xref: UniProtKB:P42525 intersection_of: only_in_taxon NCBITaxon:44689 ! Dictyostelium discoideum intersection_of: PR:000000103 ! mitogen-activated protein kinase 1 relationship: has_gene_template dictyBase:DDB_G0286353 ! erkA (Dictyostelium discoideum) [Term] id: PR:P28482-2 name: mitogen-activated protein kinase 1 isoform h2 (human) def: "A mitogen-activated protein kinase 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P28482-2." [PRO:DNx, UniProtKB:P28482] comment: Category=organism-sequence. synonym: "hMAPK1/iso:h2" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P28482-2 is_a: PR:P28482 ! mitogen-activated protein kinase 1 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P28482-1 name: mitogen-activated protein kinase 1 isoform 1 (human) def: "A mitogen-activated protein kinase 1 isoform 1 that is encoded in the genome of human." [PRO:CNA] comment: Category=organism-sequence. Requested by=PubChem. synonym: "hMAPK1/iso:1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P28482-1 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000000289 ! mitogen-activated protein kinase 1 isoform 1 [Term] id: PR:000018278 name: mitogen-activated protein kinase 1, initiator methionine removed form def: "A mitogen-activated protein kinase 1 that has had the initiator methionine removed." [PRO:DNx] comment: Category=modification. synonym: "MAPK1/InitMet-" EXACT PRO-short-label [PRO:DNx] intersection_of: PR:000000103 ! mitogen-activated protein kinase 1 intersection_of: lacks_part PR:000021937 ! initiator methionine [Term] id: PR:000025465 name: mitogen-activated protein kinase 1 isoform 1, initiator methionine removed form def: "A mitogen-activated protein kinase 1 isoform 1 that has had the initiator methionine removed." [PRO:DNx] comment: Category=modification. synonym: "MAPK1/iso:1/InitMet-" EXACT PRO-short-label [PRO:DNx] intersection_of: PR:000000289 ! mitogen-activated protein kinase 1 isoform 1 intersection_of: lacks_part PR:000021937 ! initiator methionine [Term] id: PR:000000556 name: mitogen-activated protein kinase 1 isoform 1 phosphorylated 1 def: "A mitogen-activated protein kinase 1 isoform 1 phosphorylated form that is phosphorylated at both Thr and Tyr of the TxY motif within the protein kinase domain. Example: UniProtKB:P28482-1, Thr-185, MOD:00047|Tyr-187, MOD:00048." [PMID:17192257, PMID:1849075, PRO:CNA] comment: Category=modification. synonym: "ERK-2 active form" RELATED [] synonym: "MAPK1/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx] is_a: PR:000000454 ! mitogen-activated protein kinase 1 isoform 1 phosphorylated form relationship: has_part MOD:00047 ! O-phospho-L-threonine relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine [Term] id: PR:000036466 name: mitogen-activated protein kinase 1 isoform 1 phosphorylated 1 (rat) def: "A mitogen-activated protein kinase 1 isoform 1 phosphorylated 1 in rat. UniProtKB:P63086-1, Thr-183, MOD:00047|Tyr-185, MOD:00048." [PMID:9604935, PRO:CNA] comment: Category=organism-modification. synonym: "rMAPK1/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P63086-1, Thr-183, MOD:00047|Tyr-185, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus intersection_of: PR:000000556 ! mitogen-activated protein kinase 1 isoform 1 phosphorylated 1 relationship: has_part MOD:00047 ! O-phospho-L-threonine relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine [Term] id: PR:000026341 name: mitogen-activated protein kinase 1 isoform 1 phosphorylated 1 (human) def: "A mitogen-activated protein kinase 1 isoform 1 phosphorylated 1 in human. UniProtKB:P28482-1, Thr-185, MOD:00047|Tyr-187, MOD:00048." [PRO:DNx, UniProtKB:P28482] comment: Category=organism-modification. synonym: "hMAPK1/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P28482-1, Thr-185, MOD:00047|Tyr-187, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000000556 ! mitogen-activated protein kinase 1 isoform 1 phosphorylated 1 relationship: has_part MOD:00047 ! O-phospho-L-threonine relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine [Term] id: PR:000000289 name: mitogen-activated protein kinase 1 isoform 1 def: "A mitogen-activated protein kinase 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P28482-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN] comment: Category=sequence. synonym: "MAPK1/iso:1" EXACT PRO-short-label [PRO:DNx] is_a: PR:000000103 ! mitogen-activated protein kinase 1 [Term] id: PR:P39745-2 name: mitogen-activated protein kinase mpk-1 isoform a (worm) def: "A mitogen-activated protein kinase mpk-1 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P39745-2." [PRO:DNx, UniProtKB:P39745] comment: Category=organism-sequence. synonym: "MAPK1/iso:a (worm)" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P39745-2 is_a: PR:P39745 ! mitogen-activated protein kinase mpk-1 (worm) relationship: only_in_taxon NCBITaxon:6239 ! Caenorhabditis elegans [Term] id: PR:P28482 name: mitogen-activated protein kinase 1 (human) def: "A mitogen-activated protein kinase 1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P28482] comment: Category=organism-gene. synonym: "ERK2" RELATED Gene-based [UniProtKB:P28482] synonym: "MAPK1" RELATED Gene-based [UniProtKB:P28482] synonym: "PRKM1" RELATED Gene-based [UniProtKB:P28482] synonym: "PRKM2" RELATED Gene-based [UniProtKB:P28482] synonym: "hMAPK1" EXACT PRO-short-label [PRO:DNx] synonym: "ERT1 (human)" EXACT [UniProtKB:P28482] synonym: "ERK-2 (human)" EXACT [UniProtKB:P28482] synonym: "MAPK 1 (human)" EXACT [UniProtKB:P28482] synonym: "MAPK 2 (human)" EXACT [UniProtKB:P28482] synonym: "p42-MAPK (human)" EXACT [UniProtKB:P28482] synonym: "MAP kinase 1 (human)" EXACT [UniProtKB:P28482] synonym: "MAP kinase 2 (human)" EXACT [UniProtKB:P28482] synonym: "MAP kinase isoform p42 (human)" EXACT [UniProtKB:P28482] synonym: "mitogen-activated protein kinase 2 (human)" EXACT [UniProtKB:P28482] synonym: "extracellular signal-regulated kinase 2 (human)" EXACT [UniProtKB:P28482] xref: DTO:03100315 xref: UniProtKB:P28482 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000000103 ! mitogen-activated protein kinase 1 relationship: has_gene_template HGNC:6871 ! MAPK1 (human) [Term] id: PR:P39745-1 name: mitogen-activated protein kinase mpk-1 isoform b (worm) def: "A mitogen-activated protein kinase mpk-1 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P39745-1." [PRO:DNx, UniProtKB:P39745] comment: Category=organism-sequence. synonym: "MAPK1/iso:b (worm)" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P39745-1 is_a: PR:P39745 ! mitogen-activated protein kinase mpk-1 (worm) relationship: only_in_taxon NCBITaxon:6239 ! Caenorhabditis elegans [Term] id: PR:000025458 name: mitogen-activated protein kinase 1 proteolytic cleavage product def: "A mitogen-activated protein kinase 1 that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "MAPK1/ClvPrd" EXACT PRO-short-label [PRO:DNx] intersection_of: output_of GO:0016485 ! protein processing intersection_of: PR:000000103 ! mitogen-activated protein kinase 1 [Term] id: PR:000048314 name: mitogen-activated protein kinase 1, initiator methionine removed phosphorylated 1 (human) def: "A mitogen-activated protein kinase 1 (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at position 185, and phosphotyrosine at position 187 of the amino acid sequence represented by UniProtKB:P28482. UniProtKB:P28482, 2-360, Thr-185, MOD:00047|Tyr-187, MOD:00048." [PRO:DNx, Reactome:R-HSA-109853, Reactome:R-HSA-112354] comment: Category=organism-modification. synonym: "hMAPK1/InitMet-/Phos:1" EXACT PRO-short-label [PRO:DNx] synonym: "PRO_0000186247, Thr-185, MOD:00047|Tyr-187, MOD:00048" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "UniProtKB:P28482, 2-360, Thr-185, MOD:00047|Tyr-187, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-109853 "PR:000048314 located_in GO:0005829" xref: Reactome:R-HSA-112354 "PR:000048314 located_in GO:0005654" is_a: PR:P28482 ! mitogen-activated protein kinase 1 (human) relationship: has_part MOD:00047 ! O-phospho-L-threonine relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens relationship: lacks_part PR:000021937 ! initiator methionine [Term] id: PR:000045734 name: mitogen-activated protein kinase 1 phosphorylated 1 (human) def: "A mitogen-activated protein kinase 1 (human) that has been phosphorylated on the residue at the position equivalent to Ser-29 of the amino acid sequence represented by UniProtKB:P28482-1. Example: UniProtKB:P28482-1, Ser-29, MOD:00046." [PMID:19447520, iPTMnet:P28482] comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:19447520). Status=unreviewed. synonym: "hMAPK1/Phos:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P28482-1, Ser-29, MOD:00046" NARROW PRO-proteoform-std [PRO:DNx] is_a: PR:P28482 ! mitogen-activated protein kinase 1 (human) relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000036464 name: mitogen-activated protein kinase 1 isoform 1 phosphorylated 1 (mouse) def: "A mitogen-activated protein kinase 1 isoform 1 phosphorylated 1 in mouse. UniProtKB:P63085-1, Thr-183, MOD:00047|Tyr-185, MOD:00048." [PMID:11684667, PMID:11726647, PMID:12223545, PMID:12925581, PMID:14744933, PMID:15284227, PMID:15314156, PMID:16251435, PMID:8626447, PRO:CNA] comment: Category=organism-modification. synonym: "mMAPK1/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P63085-1, Thr-183, MOD:00047|Tyr-185, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000000556 ! mitogen-activated protein kinase 1 isoform 1 phosphorylated 1 relationship: has_part MOD:00047 ! O-phospho-L-threonine relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine [Term] id: PR:000048313 name: mitogen-activated protein kinase 1, initiator methionine removed form (human) def: "A mitogen-activated protein kinase 1 (human) that has had the initiator methionine removed. UniProtKB:P28482, 2-360." [PRO:DNx, Reactome:R-HSA-199960, Reactome:R-HSA-59282] comment: Category=organism-modification. synonym: "PRO_0000186247" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "hMAPK1/InitMet-" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P28482, 2-360" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-59282 "PR:000048313 located_in GO:0005829" xref: Reactome:R-HSA-199960 "PR:000048313 located_in GO:0005654" xref: Reactome:R-HSA-6806250 "PR:000048313 located_in GO:0005576" xref: Reactome:R-HSA-6799225 "PR:000048313 located_in GO:0035578" xref: Reactome:R-HSA-6800964 "PR:000048313 located_in GO:1904813" xref: Reactome:R-HSA-9636293 "PR:000048313 located_in GO:0005788" intersection_of: lacks_part PR:000021937 ! initiator methionine intersection_of: PR:P28482 ! mitogen-activated protein kinase 1 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens