[Term]
id: PR:000000129
name: thrombospondin-1
def: "A thrombospondin subgroup A that is a translation product of the human THBS1 gene or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=gene.
synonym: "TSP" RELATED Gene-based []
synonym: "TSP1" RELATED Gene-based []
synonym: "THBS1" EXACT PRO-short-label [PRO:DNx]
synonym: "glycoprotein G" EXACT []
is_a: PR:000000029 ! thrombospondin subgroup A

[Term]
id: PR:P07996
name: thrombospondin-1 (human)
def: "A thrombospondin-1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P07996]
comment: Category=organism-gene.
synonym: "TSP" RELATED Gene-based [UniProtKB:P07996]
synonym: "TSP1" RELATED Gene-based [UniProtKB:P07996]
synonym: "THBS1" RELATED Gene-based [UniProtKB:P07996]
synonym: "hTHBS1" EXACT PRO-short-label [PRO:DNx]
synonym: "glycoprotein G (human)" EXACT [UniProtKB:P07996]
xref: UniProtKB:P07996
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000129 ! thrombospondin-1
relationship: has_gene_template HGNC:11785 ! THBS1 (human)

[Term]
id: PR:P07996-2
name: thrombospondin-1 isoform 2 (human)
def: "A thrombospondin-1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P07996-2." [PRO:DNx, UniProtKB:P07996]
comment: Category=organism-sequence.
synonym: "hTHBS1/iso:2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P07996-2
is_a: PR:P07996 ! thrombospondin-1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P07996-1
name: thrombospondin-1 isoform 1 (human)
def: "A thrombospondin-1 isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hTHBS1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P07996-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000376 ! thrombospondin-1 isoform 1

[Term]
id: PR:000028410
name: thrombospondin-1, signal peptide removed form (human)
def: "A thrombospondin-1, signal peptide removed form in human. Example: UniProtKB:P07996-1, 19-1170." [PRO:DNx]
comment: Category=organism-modification.
synonym: "PRO_0000035842" NARROW PRO-proteoform-ftid [PRO:DAN]
synonym: "hTHBS1/SigPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P07996-1, 19-1170" NARROW PRO-proteoform-std [PRO:DAN]
xref: Reactome:R-HSA-114701 "PR:000028410 located_in GO:0031093"
xref: Reactome:R-HSA-66518 "PR:000028410 located_in GO:0005576"
xref: Reactome:R-HSA-5173263 "PR:000028410 located_in GO:0005788"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000018282 ! thrombospondin-1, signal peptide removed form

[Term]
id: PR:000028966
name: thrombospondin-1 isoform 1 cleaved 2 (human)
def: "A thrombospondin-1 isoform 1 cleaved 2 in human. UniProtKB:P07996-1, 19-311." [PRO:DAN]
comment: Category=organism-modification.
synonym: "hTHBS1/iso:1/Clv:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P07996-1, 19-311" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000588 ! thrombospondin-1 isoform 1 cleaved 2

[Term]
id: PR:000036489
name: thrombospondin-1 isoform 1 cleaved 2 glycosylated 1 (human)
def: "A thrombospondin-1 isoform 1 cleaved 2 glycosylated form in human and that has been post-translationally modified at four Trp residues, one Ser residue, and two Thr residues. UniProtKB:P07996-1, 312-1170, Trp-385/Trp-438/Trp-441/Trp-498, MOD:00222|Ser-394, MOD:00812|Thr-450/Thr-507, MOD:00813." [PMID:11067851, PRO:CNA]
comment: Category=organism-modification.
synonym: "hTHBS1/iso:1/Clv:2/Glyco:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P07996-1, 312-1170, Trp-385/Trp-438/Trp-441/Trp-498, MOD:00222|Ser-394, MOD:00812|Thr-450/Thr-507, MOD:00813" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:000000590 ! thrombospondin-1 isoform 1 cleaved 2 glycosylated form
relationship: has_part MOD:00222 ! 2'-alpha-mannosyl-L-tryptophan
relationship: has_part MOD:00812 ! O-fucosyl-L-serine
relationship: has_part MOD:00813 ! O-fucosyl-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000036488
name: thrombospondin-1 isoform 1, signal peptide removed glycosylated 1 (human)
def: "A thrombospondin-1 isoform 1, signal peptide removed glycosylated form that is in human and has been post-translationally modified at four Trp residues, one Ser residue, and two Thr residues. UniProtKB:P07996-1, 19-1170, Trp-385/Trp-438/Trp-441/Trp-498, MOD:00222|Ser-394, MOD:00812|Thr-450/Thr-507, MOD:00813." [PMID:11067851, PMID:12450399, PMID:15342643, PMID:3305519, PRO:CNA]
comment: Category=organism-modification.
synonym: "hTHBS1/iso:1/SigPep-/Glyco:1" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000035842, Trp-385/Trp-438/Trp-441/Trp-498, MOD:00222|Ser-394, MOD:00812|Thr-450/Thr-507, MOD:00813" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P07996-1, 19-1170, Trp-385/Trp-438/Trp-441/Trp-498, MOD:00222|Ser-394, MOD:00812|Thr-450/Thr-507, MOD:00813" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:000000589 ! thrombospondin-1 isoform 1, signal peptide removed glycosylated form
relationship: has_part MOD:00222 ! 2'-alpha-mannosyl-L-tryptophan
relationship: has_part MOD:00812 ! O-fucosyl-L-serine
relationship: has_part MOD:00813 ! O-fucosyl-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000026338
name: thrombospondin-1 isoform 1, signal peptide removed form (human)
def: "A thrombospondin-1 isoform 1, signal peptide removed form in human. UniProtKB:P07996-1, 19-1170." [PRO:DNx, UniProtKB:P07996]
comment: Category=organism-modification.
synonym: "PRO_0000035842" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hTHBS1/iso:1/SigPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P07996-1, 19-1170" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000587 ! thrombospondin-1 isoform 1, signal peptide removed form