[Term]
id: PR:P16599
name: tumor necrosis factor (rat)
def: "A tumor necrosis factor that is encoded in the genome of rat." [OMA:P16599, PANTHER:PTHR11471:SF8, PRO:DNx]
comment: Category=organism-gene.
synonym: "Tnf" RELATED Gene-based [UniProtKB:P16599]
synonym: "Tnfa" RELATED Gene-based [UniProtKB:P16599]
synonym: "rTNF" EXACT PRO-short-label [PRO:DNx]
synonym: "Tnfsf2" RELATED Gene-based [UniProtKB:P16599]
synonym: "TNF-a (rat)" EXACT [UniProtKB:P16599]
synonym: "TNF-alpha (rat)" EXACT [UniProtKB:P16599]
synonym: "cachectin (rat)" EXACT [UniProtKB:P16599]
synonym: "tumor necrosis factor ligand superfamily member 2 (rat)" EXACT [UniProtKB:P16599]
xref: UniProtKB:P16599
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000000134 ! tumor necrosis factor
relationship: has_gene_template RGD:3876 ! Tnf (rat)

[Term]
id: PR:P06804
name: tumor necrosis factor (mouse)
def: "A tumor necrosis factor that is encoded in the genome of mouse." [OMA:P06804, PRO:DNx]
comment: Category=organism-gene.
synonym: "Tnf" RELATED Gene-based [UniProtKB:P06804]
synonym: "Tnfa" RELATED Gene-based [UniProtKB:P06804]
synonym: "mTNF" EXACT PRO-short-label [PRO:DNx]
synonym: "Tnfsf2" RELATED Gene-based [UniProtKB:P06804]
synonym: "TNF-a (mouse)" EXACT [UniProtKB:P06804]
synonym: "TNF-alpha (mouse)" EXACT [UniProtKB:P06804]
synonym: "cachectin (mouse)" EXACT [UniProtKB:P06804]
synonym: "tumor necrosis factor ligand superfamily member 2 (mouse)" EXACT [UniProtKB:P06804]
xref: UniProtKB:P06804
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000134 ! tumor necrosis factor
relationship: has_gene_template MGI:104798 ! Tnf (mouse)

[Term]
id: PR:000051774
name: tumor necrosis factor O-glycosylated 1 (human)
def: "A tumor necrosis factor (human) that has been O-glycosylated at the residue equivalent to Ser-80 of the amino acid sequence represented by UniProtKB:P01375-1, in which the glycan structure is represented by GlyTouCan:G00031MO. Example: UniProtKB:P01375-1, Ser-80, MOD:00002~GNO:G00031MO." [GlyGen:P01375-1, PMID:8631363, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hTNF/OGlyco:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P01375-1, Ser-80, MOD:00002~UniCarbKB:4" NARROW [PRO:DNx]
synonym: "UniProtKB:P01375-1, Ser-80, MOD:00002~GNO:G00031MO" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P01375 ! tumor necrosis factor (human)
relationship: has_part GNO:G00031MO ! G00031MO
relationship: has_part MOD:00002 ! O-glycosyl-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000051775
name: tumor necrosis factor O-glycosylated 2 (human)
def: "A tumor necrosis factor (human) that has been O-glycosylated at the residue equivalent to Ser-80 of the amino acid sequence represented by UniProtKB:P01375-1, in which the glycan structure is represented by GlyTouCan:G56682BC. Example: UniProtKB:P01375-1, Ser-80, MOD:00002~GNO:G56682BC." [GlyGen:P01375-1, PMID:8631363, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hTNF/OGlyco:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P01375-1, Ser-80, MOD:00002~UniCarbKB:8" NARROW [PRO:DNx]
synonym: "UniProtKB:P01375-1, Ser-80, MOD:00002~GNO:G56682BC" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P01375 ! tumor necrosis factor (human)
relationship: has_part GNO:G56682BC ! G56682BC
relationship: has_part MOD:00002 ! O-glycosyl-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P01375-1
name: tumor necrosis factor isoform 1 (human)
def: "A tumor necrosis factor isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hTNF/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P01375-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000381 ! tumor necrosis factor isoform 1

[Term]
id: PR:000000134
name: tumor necrosis factor
def: "A tumor necrosis factor, TNF-like that is a translation product of the human TNF gene or a 1:1 ortholog thereof. Tumour necrosis factor alpha (TNF) is a pleiotropic cytokine that mediates apoptosis, cell proliferation, immunomodulation, inflammation, viral replication, allergy, arthritis, septic shock, insulin resistance, autoimmune diseases, and other pathological conditions. TNF transduces these cellular responses through two distinct receptors: type I, which are expressed on all cell types, and type II, which are expressed only on cells of the immune system and endothelial cells." [PMID:11053079, PRO:CNA]
comment: Category=gene.
synonym: "TNF" EXACT PRO-short-label [PRO:DNx]
synonym: "TNFA" RELATED Gene-based []
synonym: "TNFa" EXACT []
synonym: "TNF-a" EXACT []
synonym: "TNFSF2" RELATED Gene-based []
synonym: "TNF-alpha" EXACT []
synonym: "cachectin" EXACT []
synonym: "tumor necrosis factor alpha" EXACT []
synonym: "tumor necrosis factor ligand superfamily member 2" EXACT []
xref: PIRSF:PIRSF500467
is_a: PR:000000033 ! tumor necrosis factor, TNF-like

[Term]
id: PR:000018285
name: tumor necrosis factor proteolytic cleavage product
def: "A tumor necrosis factor that has been processed by proteolytic cleavage." [PRO:DNx]
comment: Category=modification.
synonym: "TNF/ClvPrd" EXACT PRO-short-label [PRO:DNx]
intersection_of: output_of GO:0016485 ! protein processing
intersection_of: PR:000000134 ! tumor necrosis factor

[Term]
id: PR:000000497
name: tumor necrosis factor isoform 1 phosphorylated form
def: "A tumor necrosis factor isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]
comment: Category=modification.
synonym: "TNF/iso:1/PhosRes+" EXACT PRO-short-label [PRO:DNx]
intersection_of: has_part MOD:00696 ! phosphorylated residue
intersection_of: PR:000000381 ! tumor necrosis factor isoform 1

[Term]
id: PR:000000496
name: tumor necrosis factor isoform 1 myristoylated form
def: "A tumor necrosis factor isoform 1 that includes at least one myristoylated residue." [PRO:CNA]
comment: Category=modification.
synonym: "TNF/iso:1/MyrRes+" EXACT PRO-short-label [PRO:DNx]
intersection_of: has_part MOD:00438 ! myristoylated residue
intersection_of: PR:000000381 ! tumor necrosis factor isoform 1

[Term]
id: PR:P06804-1
name: tumor necrosis factor isoform 1 (mouse)
def: "A tumor necrosis factor isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "mTNF/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P06804-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000381 ! tumor necrosis factor isoform 1

[Term]
id: PR:000036504
name: tumor necrosis factor isoform 1 cleaved 1 (human)
def: "A tumor necrosis factor isoform 1 cleaved 1 in human. UniProtKB:P01375-1, 77-233." [PMID:14512626, PMID:3856324, PRO:CNA]
comment: Category=organism-modification.
synonym: "PRO_0000034424" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hTNF/iso:1/Clv:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P01375-1, 77-233" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-976821 "PR:000036504 located_in GO:0005576"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000604 ! tumor necrosis factor isoform 1 cleaved 1

[Term]
id: PR:000036505
name: tumor necrosis factor isoform 1 cleaved 1 (mouse)
def: "A tumor necrosis factor isoform 1 cleaved 1 in mouse. UniProtKB:P06804-1, 80-235." [PMID:10089307, PMID:9305915, PRO:CNA]
comment: Category=organism-modification.
synonym: "PRO_0000034436" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "mTNF/iso:1/Clv:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P06804-1, 80-235" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000604 ! tumor necrosis factor isoform 1 cleaved 1

[Term]
id: PR:000036506
name: tumor necrosis factor isoform 1 cleaved 2 (mouse)
def: "A tumor necrosis factor isoform 1 cleaved 2 in mouse. UniProtKB:P06804-1, 70-235." [PMID:2777790, PRO:CNA]
comment: Category=organism-modification.
synonym: "mTNF/iso:1/Clv:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P06804-1, 70-235" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000605 ! tumor necrosis factor isoform 1 cleaved 2

[Term]
id: PR:000036507
name: tumor necrosis factor isoform 1 myristoylated 1 (human)
def: "A tumor necrosis factor isoform 1 myristoylated 1 in human. UniProtKB:P01375-1, Lys-19/Lys-20, MOD:00087." [PMID:1402651, PRO:CNA]
comment: Category=organism-modification.
synonym: "hTNF/iso:1/Myr:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P01375-1, Lys-19/Lys-20, MOD:00087" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000606 ! tumor necrosis factor isoform 1 myristoylated 1
relationship: has_part MOD:00087 ! N6-myristoyl-L-lysine

[Term]
id: PR:000000606
name: tumor necrosis factor isoform 1 myristoylated 1
def: "A tumor necrosis factor isoform 1 myristoylated form that has been modified at the N-epsilon-NH2 groups of the most N-terminal Lys within the cytoplasmic domain. Example: UniProtKB:P01375-1, Lys-19/Lys-20, MOD:00087." [PMID:1402651]
comment: Category=modification.
synonym: "TNF/iso:1/Myr:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000496 ! tumor necrosis factor isoform 1 myristoylated form
relationship: has_part MOD:00087 ! N6-myristoyl-L-lysine

[Term]
id: PR:000000607
name: tumor necrosis factor isoform 1 phosphorylated 1
def: "A tumor necrosis factor isoform 1 phosphorylated form in which the phosphorylation occurs at the N-terminal Ser within the ST[EK]S motif in the cytoplasmic domain. Example: UniProtKB:P01375-1, Ser-2, MOD:00046." [PMID:10205166]
comment: Category=modification.
synonym: "TNF/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000497 ! tumor necrosis factor isoform 1 phosphorylated form
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:000000381
name: tumor necrosis factor isoform 1
def: "A tumor necrosis factor that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P01375-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]
comment: Category=sequence.
synonym: "TNF/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000134 ! tumor necrosis factor

[Term]
id: PR:000000605
name: tumor necrosis factor isoform 1 cleaved 2
def: "A tumor necrosis factor isoform 1 that is the inactive soluble form after alternative protein processing. The resulting protein is 10 amino acids longer than the active form." [PMID:2777790, PRO:CNA, PRO:DAN]
comment: Category=modification. Compare this to PR:000000604 (the active form).
synonym: "TNF/iso:1/Clv:2" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000381 ! tumor necrosis factor isoform 1
relationship: output_of GO:0016485 ! protein processing

[Term]
id: PR:000036508
name: tumor necrosis factor isoform 1 phosphorylated 1 (human)
def: "A tumor necrosis factor isoform 1 phosphorylated 1 in human. UniProtKB:P01375-1, Ser-2, MOD:00046." [PMID:10205166, PMID:8597870, PRO:CNA]
comment: Category=organism-modification.
synonym: "hTNF/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P01375-1, Ser-2, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000607 ! tumor necrosis factor isoform 1 phosphorylated 1
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:000000604
name: tumor necrosis factor isoform 1 cleaved 1
def: "A tumor necrosis factor isoform 1 that is the soluble C-terminal portion after processing by TNF alpha converting enzyme ADAM17." [PMID:12135369]
comment: Category=modification.
synonym: "TNF/iso:1/Clv:1" EXACT PRO-short-label [PRO:DNx]
synonym: "tumor necrosis factor soluble form" EXACT [PRO:DAN]
is_a: PR:000000381 ! tumor necrosis factor isoform 1
relationship: output_of GO:0016485 ! protein processing

[Term]
id: PR:P01375
name: tumor necrosis factor (human)
def: "A tumor necrosis factor that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-gene. Requested by=PubChem.
synonym: "TNF" RELATED Gene-based [UniProtKB:P01375]
synonym: "TNFA" RELATED Gene-based [UniProtKB:P01375]
synonym: "hTNF" EXACT PRO-short-label [PRO:DNx]
synonym: "TNFSF2" RELATED Gene-based [UniProtKB:P01375]
synonym: "TNFa (human)" EXACT [PRO:DAN]
synonym: "TNF-a (human)" EXACT [UniProtKB:P01375]
synonym: "TNF-alpha (human)" EXACT [UniProtKB:P01375]
synonym: "cachectin (human)" EXACT [UniProtKB:P01375]
synonym: "tumor necrosis factor ligand superfamily member 2 (human)" EXACT [UniProtKB:P01375]
xref: Reactome:R-HSA-66220 "PR:P01375 located_in GO:0005886"
xref: UniProtKB:P01375
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000134 ! tumor necrosis factor
relationship: has_gene_template HGNC:11892 ! TNF (human)