[Term] id: PR:Q9CUN6 name: E3 ubiquitin-protein ligase SMURF1 (mouse) def: "An E3 ubiquitin-protein ligase SMURF1 that is encoded in the genome of mouse." [OMA:Q9CUN6, PRO:DNx] comment: Category=organism-gene. synonym: "Smurf1" RELATED Gene-based [UniProtKB:Q9CUN6] synonym: "mSMURF1" EXACT PRO-short-label [PRO:DNx] synonym: "SMAD ubiquitination regulatory factor 1 (mouse)" EXACT [UniProtKB:Q9CUN6] synonym: "HECT-type E3 ubiquitin transferase SMURF1 (mouse)" EXACT [UniProtKB:Q9CUN6] synonym: "SMAD-specific E3 ubiquitin-protein ligase 1 (mouse)" EXACT [UniProtKB:Q9CUN6] xref: UniProtKB:Q9CUN6 intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000000361 ! E3 ubiquitin-protein ligase SMURF1 relationship: has_gene_template MGI:1923038 ! Smurf1 (mouse) [Term] id: PR:Q9HCE7 name: E3 ubiquitin-protein ligase SMURF1 (human) def: "An E3 ubiquitin-protein ligase SMURF1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q9HCE7] comment: Category=organism-gene. synonym: "SMURF1" RELATED Gene-based [UniProtKB:Q9HCE7] synonym: "hSMURF1" EXACT PRO-short-label [PRO:DNx] synonym: "KIAA1625" RELATED Gene-based [UniProtKB:Q9HCE7] synonym: "SMAD ubiquitination regulatory factor 1 (human)" EXACT [UniProtKB:Q9HCE7] synonym: "HECT-type E3 ubiquitin transferase SMURF1 (human)" EXACT [UniProtKB:Q9HCE7] synonym: "SMAD-specific E3 ubiquitin-protein ligase 1 (human)" EXACT [UniProtKB:Q9HCE7] xref: Reactome:R-HSA-975972 "PR:Q9HCE7 located_in GO:0005829" xref: Reactome:R-HSA-3004548 "PR:Q9HCE7 located_in GO:0005654" xref: UniProtKB:Q9HCE7 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000000361 ! E3 ubiquitin-protein ligase SMURF1 relationship: has_gene_template HGNC:16807 ! SMURF1 (human) [Term] id: PR:Q9CUN6-1 name: E3 ubiquitin-protein ligase SMURF1 isoform Short (mouse) def: "An E3 ubiquitin-protein ligase SMURF1 isoform Short that is encoded in the genome of mouse." [PRO:CNA] comment: Category=organism-sequence. synonym: "mSMURF1/iso:Short" EXACT PRO-short-label [PRO:DNx] synonym: "Smurf1 isoform 1 (mouse)" EXACT [PRO:DNx] xref: UniProtKB:Q9CUN6-1 intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000000466 ! E3 ubiquitin-protein ligase SMURF1 isoform Short [Term] id: PR:Q9HCE7-1 name: E3 ubiquitin-protein ligase SMURF1 isoform Long (human) def: "An E3 ubiquitin-protein ligase SMURF1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9HCE7-1." [PRO:DNx, UniProtKB:Q9HCE7] comment: Category=organism-sequence. synonym: "hSMURF1/iso:Long" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q9HCE7-1 is_a: PR:Q9HCE7 ! E3 ubiquitin-protein ligase SMURF1 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:Q9V853 name: E3 ubiquitin-protein ligase Smurf1 (fruit fly) def: "An E3 ubiquitin-protein ligase SMURF1 that is encoded in the genome of fruit fly." [PRO:DAN] comment: Category=organism-gene. synonym: "lack" RELATED Gene-based [UniProtKB:Q9V853] synonym: "Smurf" RELATED Gene-based [UniProtKB:Q9V853] synonym: "CG4943" RELATED Gene-based [UniProtKB:Q9V853] synonym: "Smurf1" RELATED Gene-based [UniProtKB:Q9V853] synonym: "fly-SMURF1" EXACT PRO-short-label [PRO:DNx] synonym: "DSmurf (fruit fly)" EXACT [UniProtKB:Q9V853] synonym: "lethal with a checkpoint kinase protein (fruit fly)" EXACT [UniProtKB:Q9V853] synonym: "HECT-type E3 ubiquitin transferase Smurf1 (fruit fly)" EXACT [UniProtKB:Q9V853] synonym: "SMAD ubiquitination regulatory factor 1 homolog (fruit fly)" EXACT [UniProtKB:Q9V853] xref: UniProtKB:Q9V853 intersection_of: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster intersection_of: PR:000000361 ! E3 ubiquitin-protein ligase SMURF1 relationship: has_gene_template FlyBase:FBgn0029006 ! Smurf (fruit fly) [Term] id: PR:Q9HCE7-2 name: E3 ubiquitin-protein ligase SMURF1 isoform Short (human) def: "An E3 ubiquitin-protein ligase SMURF1 isoform Short that is encoded in the genome of human." [PRO:CNA] comment: Category=organism-sequence. synonym: "hSMURF1/iso:Short" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q9HCE7-2 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000000466 ! E3 ubiquitin-protein ligase SMURF1 isoform Short [Term] id: PR:000000361 name: E3 ubiquitin-protein ligase SMURF1 def: "A smad ubiquitination regulatory factor that is a translation product of the human SMURF1 gene or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=gene. synonym: "SMURF1" EXACT PRO-short-label [PRO:DNx] synonym: "KIAA1625" RELATED Gene-based [] synonym: "SMAD ubiquitination regulatory factor 1" EXACT [] synonym: "smad ubiquitination regulatory factor 1" EXACT [PRO:CNA] synonym: "HECT-type E3 ubiquitin transferase SMURF1" EXACT [] synonym: "SMAD-specific E3 ubiquitin-protein ligase 1" EXACT [] is_a: PR:000000127 ! smad ubiquitination regulatory factor [Term] id: PR:000000466 name: E3 ubiquitin-protein ligase SMURF1 isoform Short def: "An E3 ubiquitin-protein ligase SMURF1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9HCE7-2 or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=sequence. synonym: "SMURF1/iso:Short" EXACT PRO-short-label [PRO:DNx] synonym: "smad ubiquitination regulatory factor 1 isoform 1" EXACT [PRO:CNA] is_a: PR:000000361 ! E3 ubiquitin-protein ligase SMURF1 [Term] id: PR:000049755 name: E3 ubiquitin-protein ligase SMURF1 unphosphorylated 1 (mouse) def: "An E3 ubiquitin-protein ligase SMURF1 (mouse) that lacks phosphorylation on a Ser residue equivalent to Ser-148 of the amino acid sequence represented by UniProtKB:Q9CUN6. UniProtKB:Q9CUN6, Ser-148, PR:000026291." [MGI:1923038, PMID:27052174, PRO:HJD] comment: Category=organism-modification. synonym: "mSMURF1/UnPhos:1" EXACT PRO-short-label [PRO:DNx] synonym: "SMURF1 unphosphorylated 1" RELATED [] synonym: "UniProtKB:Q9CUN6, Ser-148, PR:000026291" EXACT PRO-proteoform-std [PRO:DNx] is_a: PR:Q9CUN6 ! E3 ubiquitin-protein ligase SMURF1 (mouse) relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus [Term] id: PR:000049754 name: E3 ubiquitin-protein ligase SMURF1 phosphorylated 1 (mouse) def: "An E3 ubiquitin-protein ligase SMURF1 (mouse) that has been phosphorylated on a Ser residue equivalent to Ser-148 of the amino acid sequence represented by UniProtKB:Q9CUN6. UniProtKB:Q9CUN6, Ser-148, MOD:00046." [MGI:1923038, PMID:27052174, PRO:HJD] comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:27052174). synonym: "mSMURF1/Phos:1" EXACT PRO-short-label [PRO:DNx] synonym: "SMURF1 phosphorylated 1" RELATED [] synonym: "UniProtKB:Q9CUN6, Ser-148, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx] is_a: PR:Q9CUN6 ! E3 ubiquitin-protein ligase SMURF1 (mouse) relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus