[Term]
id: PR:000000570
name: smad1 isoform 1 phosphorylated and ubiquitinated form
def: "A smad1 isoform 1 that includes at least one phosphorylated residue and at least one ubiquitinated lysine." [PRO:CNA]
comment: Category=modification.
synonym: "SMAD1/iso:1/PhosUbiq+" EXACT PRO-short-label [PRO:DNx]
intersection_of: has_part MOD:00696 ! phosphorylated residue
intersection_of: has_part MOD:01148 ! ubiquitinylated lysine
intersection_of: PR:000000467 ! smad1 isoform 1

[Term]
id: PR:000000571
name: smad1 isoform 1 phosphorylated form
def: "A smad1 isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]
comment: Category=modification.
synonym: "SMAD1/iso:1/PhosRes+" EXACT PRO-short-label [PRO:DNx]
intersection_of: has_part MOD:00696 ! phosphorylated residue
intersection_of: PR:000000467 ! smad1 isoform 1

[Term]
id: PR:000000648
name: smad1 isoform 1 phosphorylated and ubiquitinated 1
def: "A smad1 isoform 1 phosphorylated and ubiquitinated form that has been phosphorylated at the two last C-terminal SSxS motif and has been ubiquitinated by E3 ubiquitin-protein ligase SMURF1 (PR:000000466). Example: UniProtKB:Q15797-1, Ser-463/Ser-465, MOD:00046|MOD:01148." [PMID:12857866, PRO:CNA, PRO:DAN]
comment: Category=modification.
synonym: "SMAD1/iso:1/PhosUbiq:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000570 ! smad1 isoform 1 phosphorylated and ubiquitinated form
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:01148 ! ubiquitinylated lysine

[Term]
id: PR:000049280
name: mothers against decapentaplegic homolog 1 ubiquitinated form (human)
def: "A mothers against decapentaplegic homolog 1 (human) that includes at least one ubiquitinated lysine. UniProtKB:Q15797, MOD:01148." [PRO:DNx, Reactome:R-HSA-6782768]
comment: Category=organism-modification.
synonym: "hSMAD1/UbiqLys+" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q15797, MOD:01148" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-6782768 "PR:000049280 located_in GO:0005829"
intersection_of: has_part MOD:01148 ! ubiquitinylated lysine
intersection_of: PR:Q15797 ! mothers against decapentaplegic homolog 1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P70340-1
name: mothers against decapentaplegic homolog 1 isoform 1 (mouse)
def: "A smad1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "mSMAD1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P70340-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000467 ! smad1 isoform 1

[Term]
id: PR:Q15797-2
name: mothers against decapentaplegic homolog 1 isoform h2 (human)
def: "A mothers against decapentaplegic homolog 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q15797-2." [PRO:DNx, UniProtKB:Q15797]
comment: Category=organism-sequence.
synonym: "hSMAD1/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q15797-2
is_a: PR:Q15797 ! mothers against decapentaplegic homolog 1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q15797-1
name: mothers against decapentaplegic homolog 1 isoform 1 (human)
def: "A smad1 isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hSMAD1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q15797-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000467 ! smad1 isoform 1

[Term]
id: PR:P97588
name: mothers against decapentaplegic homolog 1 (rat)
def: "A smad1 that is encoded in the genome of rat." [OMA:P97588, PRO:DNx]
comment: Category=organism-gene.
synonym: "Mad1" RELATED Gene-based [UniProtKB:P97588]
synonym: "Madh1" RELATED Gene-based [UniProtKB:P97588]
synonym: "Smad1" RELATED Gene-based [UniProtKB:P97588]
synonym: "rSMAD1" EXACT PRO-short-label [PRO:DNx]
synonym: "SMAD 1 (rat)" EXACT [UniProtKB:P97588]
synonym: "MAD homolog 1 (rat)" EXACT [UniProtKB:P97588]
synonym: "SMAD family member 1 (rat)" EXACT [UniProtKB:P97588]
synonym: "mothers against DPP homolog 1 (rat)" EXACT [UniProtKB:P97588]
xref: UniProtKB:P97588
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000000363 ! smad1
relationship: has_gene_template RGD:3030 ! Smad1 (rat)

[Term]
id: PR:000000647
name: smad1 isoform 1 phosphorylated 1
def: "A smad1 isoform 1 phosphorylated form in which the phosphorylation occurs at the C-terminal SSxS motif as a result of the activation of the bone morphogenetic protein (BMP) signaling pathway. Example: UniProtKB:Q15797-1, Ser-463/Ser-465, MOD:00046." [PMID:9136927]
comment: Category=modification.
synonym: "SMAD1/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "BMP receptor-activated smad1" RELATED []
is_a: PR:000000571 ! smad1 isoform 1 phosphorylated form
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:000050148
name: smad1 phosphorylated 1
def: "A smad1 that has been phosphorylated on the last two Ser residues within the C-terminal SSxS motif as a result of the activation of the bone morphogenetic protein (BMP) signaling pathway. Example: UniProtKB:Q15797, Ser-463/Ser-465, MOD:00046." [PRO:DAN]
comment: Category=modification.
synonym: "SMAD1/Phos:1" EXACT PRO-short-label [PRO:DAN]
synonym: "BMP receptor-activated smad1" EXACT []
is_a: PR:000000363 ! smad1
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:000026724
name: smad1 isoform 1 phosphorylated 1 (mouse)
def: "A smad1 isoform 1 phosphorylated 1 in mouse. UniProtKB:P70340-1, Ser-463/Ser-465, MOD:00046." [PMID:10504300, PMID:12151307, PMID:12370310]
comment: Category=organism-modification.
synonym: "mSMAD1/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P70340-1, Ser-463/Ser-465, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000647 ! smad1 isoform 1 phosphorylated 1
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:000026334
name: smad1 isoform 1 phosphorylated 1 (human)
def: "A smad1 isoform 1 phosphorylated 1 in human. UniProtKB:Q15797-1, Ser-463/Ser-465, MOD:00046." [PRO:DAN, Reactome:R-HSA-201464, Reactome:R-HSA-201483]
comment: Category=organism-modification.
synonym: "hSMAD1/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "phospho-R-smad1 (human)" EXACT [Reactome:R-HSA-201464]
synonym: "UniProtKB:Q15797-1, Ser-463/Ser-465, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000647 ! smad1 isoform 1 phosphorylated 1
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:P70340
name: mothers against decapentaplegic homolog 1 (mouse)
def: "A smad1 that is encoded in the genome of mouse." [OMA:P70340, PRO:DNx]
comment: Category=organism-gene.
synonym: "Madh1" RELATED Gene-based [UniProtKB:P70340]
synonym: "Madr1" RELATED Gene-based [UniProtKB:P70340]
synonym: "Smad1" RELATED Gene-based [UniProtKB:P70340]
synonym: "mMad1" EXACT [UniProtKB:P70340]
synonym: "mSMAD1" EXACT PRO-short-label [PRO:DNx]
synonym: "Dwf-A (mouse)" EXACT [UniProtKB:P70340]
synonym: "SMAD 1 (mouse)" EXACT [UniProtKB:P70340]
synonym: "dwarfin-A (mouse)" EXACT [UniProtKB:P70340]
synonym: "MAD homolog 1 (mouse)" EXACT [UniProtKB:P70340]
synonym: "SMAD family member 1 (mouse)" EXACT [UniProtKB:P70340]
synonym: "Mad-related protein 1 (mouse)" EXACT [UniProtKB:P70340]
synonym: "mothers against DPP homolog 1 (mouse)" EXACT [UniProtKB:P70340]
synonym: "mothers-against-DPP-related 1 (mouse)" EXACT [UniProtKB:P70340]
xref: UniProtKB:P70340
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000363 ! smad1
relationship: has_gene_template MGI:109452 ! Smad1 (mouse)

[Term]
id: PR:000000363
name: smad1
def: "A BMP receptor-regulated smad protein that is a translation product of the human SMAD1 gene or a 1:1 ortholog thereof." [PMID:10708949, PRO:CNA]
comment: Category=gene.
synonym: "BSP1" RELATED Gene-based []
synonym: "Mad1" EXACT []
synonym: "BSP-1" EXACT []
synonym: "Dwf-A" EXACT []
synonym: "JV4-1" EXACT []
synonym: "MADH1" RELATED Gene-based []
synonym: "MADR1" RELATED Gene-based []
synonym: "SMAD1" EXACT PRO-short-label [PRO:DNx]
synonym: "SMAD 1" EXACT []
synonym: "dwarfin-A" EXACT []
synonym: "MAD homolog 1" EXACT []
synonym: "SMAD family member 1" EXACT []
synonym: "Mad-related protein 1" EXACT []
synonym: "mothers against DPP homolog 1" EXACT []
synonym: "mothers-against-DPP-related 1" EXACT []
synonym: "transforming growth factor-beta-signaling protein 1" EXACT []
is_a: PR:000000038 ! BMP receptor-regulated smad protein

[Term]
id: PR:000000467
name: smad1 isoform 1
def: "A smad1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q15797-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]
comment: Category=sequence.
synonym: "SMAD1/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000363 ! smad1

[Term]
id: PR:Q15797
name: mothers against decapentaplegic homolog 1 (human)
def: "A smad1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q15797]
comment: Category=organism-gene.
synonym: "BSP1" RELATED Gene-based [UniProtKB:Q15797]
synonym: "MADH1" RELATED Gene-based [UniProtKB:Q15797]
synonym: "MADR1" RELATED Gene-based [UniProtKB:Q15797]
synonym: "SMAD1" RELATED Gene-based [UniProtKB:Q15797]
synonym: "hSMAD1" EXACT PRO-short-label [PRO:DNx]
synonym: "BSP-1 (human)" EXACT [UniProtKB:Q15797]
synonym: "JV4-1 (human)" EXACT [UniProtKB:Q15797]
synonym: "Smad1 (human)" EXACT [UniProtKB:Q15797]
synonym: "SMAD 1 (human)" EXACT [UniProtKB:Q15797]
synonym: "MAD homolog 1 (human)" EXACT [UniProtKB:Q15797]
synonym: "SMAD family member 1 (human)" EXACT [UniProtKB:Q15797]
synonym: "Mad-related protein 1 (human)" EXACT [UniProtKB:Q15797]
synonym: "mothers against DPP homolog 1 (human)" EXACT [UniProtKB:Q15797]
synonym: "transforming growth factor-beta-signaling protein 1 (human)" EXACT [UniProtKB:Q15797]
xref: Reactome:R-HSA-201468 "PR:Q15797 located_in GO:0005829"
xref: UniProtKB:Q15797
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000363 ! smad1
relationship: has_gene_template HGNC:6767 ! SMAD1 (human)

[Term]
id: PR:000036553
name: smad1 isoform 1 phosphorylated and ubiquitinated 1 (human)
def: "A smad1 isoform 1 phosphorylated and ubiquitinated 1 in human. UniProtKB:Q15797-1, Ser-463/Ser-465, MOD:00046|MOD:01148." [PMID:12857866, PRO:CNA, PRO:DAN]
comment: Category=organism-modification.
synonym: "hSMAD1/iso:1/PhosUbiq:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q15797-1, Ser-463/Ser-465, MOD:00046|MOD:01148" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000648 ! smad1 isoform 1 phosphorylated and ubiquitinated 1
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:01148 ! ubiquitinylated lysine

[Term]
id: PR:000050147
name: smad1 phosphorylated 1 (human)
def: "A smad1 phosphorylated 1 in human. UniProtKB:Q15797, Ser-463/Ser-465, MOD:00046." [PRO:DAN]
comment: Category=organism-modification.
synonym: "hSMAD1/Phos:1" EXACT PRO-short-label [PRO:DAN]
synonym: "UniProtKB:Q15797, Ser-463/Ser-465, MOD:00046" EXACT PRO-proteoform-std [PRO:DAN]
xref: Reactome:R-HSA-201464 "PR:000050147 located_in GO:0005829"
xref: Reactome:R-HSA-201483 "PR:000050147 located_in GO:0005654"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000050148 ! smad1 phosphorylated 1
relationship: has_part MOD:00046 ! O-phospho-L-serine